A5111911526- Lipoproteins and Cardiovascular Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer, Lipids, and Metabolism
- Liver Disease Diagnosis and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- HIV-related health complications and treatments
- Chronic Kidney Disease and Diabetes
- Blood Pressure and Hypertension Studies
- Neuroendocrine Tumor Research Advances
- Dialysis and Renal Disease Management
- Liver Disease and Transplantation
- Cardiovascular Disease and Adiposity
- Neuroblastoma Research and Treatments
- Cardiovascular Health and Disease Prevention
- Cardiac Imaging and Diagnostics
- HIV Research and Treatment
- Fatty Acid Research and Health
- Cardiovascular Function and Risk Factors
- Lung Cancer Research Studies
- Lysosomal Storage Disorders Research
- Coronary Interventions and Diagnostics
- Cerebrovascular and Carotid Artery Diseases
- Calcium signaling and nucleotide metabolism
- Diet, Metabolism, and Disease
- Drug-Induced Hepatotoxicity and Protection
The Royal Free Hospital
2014-2025
University College London
2014-2025
Kidney Research UK
2024
Royal Free London NHS Foundation Trust
2010-2020
North Middlesex Hospital
2018
The Wellington Hospital
2017
Royal London Hospital
2016
Roland Hill (United Kingdom)
2016
St George's, University of London
2010
Hospital Universitari Sant Joan de Reus
2008
Aims The aims of this study were to evaluate the diagnostic value and explore prognostic N-terminal brain natriuretic peptide (N-TproBNP) in patients with systemic sclerosis (SSc) both without pulmonary arterial hypertension (PAH). Methods results N-TproBNP, six-minute walk distance (SMWD), haemodynamics (at right heart catheterization) or tricuspid gradient (by echocardiography), survival assessed 109 SSc. population included 68 individuals PAH [mean artery pressure (PAP) >25 mmHg capillary...
BackgroundValidated prediction scores are required to assess the risks of end-stage renal disease (ESRD) and death in individuals with chronic kidney (CKD).Study DesignProspective cohort study validation a separate cohort.Setting & ParticipantsCox regression was used relevance baseline characteristics risk ESRD (mean follow-up, 4.1 years) 6.0 382 patients stages 3-5 CKD not initially on dialysis therapy Chronic Renal Impairment Birmingham (CRIB) Study. Resultant equations were tested 213...
Objective— To investigate the hypothesis that release of adipokines by epicardial adipose tissue (EAT) is dysregulated in obesity and/or coronary artery disease (CAD), along with previously documented expansion tissue, and these molecules induce pathophysiological changes human monocytes endothelial cells. Methods Results— In white nondiabetic patients CAD (n=62) or without (control group) (n=32), subdivided body mass index ≤27 >27, 13 cytokines were identified protein array analysis as...
Bilirubin (Bil) interferes with creatinine (Cr) measurement. Different laboratory methods are used to overcome this problem. Model for end-stage liver disease (MELD) scoring incorporates Cr and is prioritize patients transplantation. Thus, MELD scores may vary different measurements influencing patients' priority. Our aim was evaluate 4 assays (O'Leary modified Jaffe [mJCr], compensated [rate blanked] kinetic [cJCr], enzymatic [ECr], standard [JCr]) in abnormal function tests assess changes...
Familial hypercholesterolaemia (FH) is an autosomal dominant disease of lipid metabolism, which leads to early coronary heart disease. Mutations in LDLR, APOB and PCSK9 can be detected 80% definite FH (DFH) patients. This study aimed identify novel FH-causing genetic variants patients with no detectable mutation.Exomes 125 unrelated DFH were sequenced, as part the UK10K project. First, analysis known genes identified 23 LDLR two mutations, explained causes excluded from further analysis....
Proteins play a crucial role in metabolism, maintaining fluid and acid-base balance antibody synthesis. Dietary proteins are important nutrients classified into: 1) animal (meat, fish, poultry, eggs dairy), and, 2) plant (legumes, nuts soy). modification is one of the most lifestyle changes that has been shown to significantly decrease risk cardiovascular (CV) disease (CVD) by attenuating related factors. The CVD burden reduced optimum diet through replacement unprocessed meat with low...
Objective : In 2016, the Lipid Association of India (LAI) developed a cardiovascular risk assessment algorithm and defined low-density lipoprotein cholesterol (LDL-C) goals for prevention atherosclerotic disease (ASCVD) in Indians. The recent refinements role various factors subclinical atherosclerosis prediction ASCVD necessitated updating treatment goals. Methods LAI core committee held twenty-one meetings webinars from June 2022 to July 2023 with experts across critically reviewed latest...
Background and aimsFamilial hypercholesterolemia (FH) is a common inherited disorder of low density lipoprotein-cholesterol (LDL-C) metabolism. It associated with higher risk premature coronary heart disease. Around 60% patients clinical diagnosis FH do not have detectable mutation in the genes causing are most likely to polygenic cause for their raised LDL-C. We assessed degree preclinical atherosclerosis treated monogenic versus hypercholesterolemia.MethodsFH testing genotypes six...
Background: Recent guidelines underline the need for high-risk patients to reach strict low density lipoprotein cholesterol (LDL‑C) targets (1.8–2.6 mmol/L; 70–100 mg/dL), and specifically mention possible use of combination therapy (e.g. statin + ezetimibe) achieve these goals.Methods: A retrospective case-note audit was carried out assess response administering ezetimibe in unable tolerate statins (Group 1), or high dose 2) who cannot LDL‑C target (2.6 100 mg/dL) despite taking a...
Summary Background and objectives Renal function is an important predictor of survival in cirrhosis liver transplantation. GFR estimates using serum cystatin C (CysC) are proposed as better predictors renal than ones on the basis creatinine (Cr). Our aims were: ( 1 ) evaluate correlations between CysC different methods measurements; 2 compare Cr formulas with 51 Cr-EDTA; 3 liver-related parameters potentially influencing GFR. Design, setting, participants, & measurements 254 blood...
Current diagnostic methods for JIA lack specificity, often failing to distinguish it from other childhood diseases of similar clinical presentations. The present study is a comparative cross-sectional that identified potential biomarkers using label-free mass spectrometry and bioinformatics. Two differentially expressed proteins (DEPs), Myosin light chain 12b (Myl12b) Mannose-binding lectin serine protease 1 (MASP1), showed increased expression in patients. Receiver operating characteristic...
Shorter telomeres have been reported in premature myocardial infarction (MI) patients. Our work aimed at confirming the association of shorter telomere with MI two case-control studies and familial hypercholesterolemia (FH) patients coronary heart disease (CHD). The HIFMECH study compared 598 white male (<60 years) who survived a first 653 age-matched controls from North South Europe. Additionally, UK, 413 artery bypass graft (CABG) groups 367 94 FH patients, whom 145 17 respectively had...
Background The value of screening sub‐clinical atherosclerosis in asymptomatic patients with type 2 diabetes mellitus (T2DM) remains controversial. Hypothesis An integrated model incorporating carotid intima‐media thickness (CIMT) and plaque traditional risk factors can be used to predict prevalence severity coronary artery calcification T2DM patients. Methods A cohort 262 were prospectively studied ultrasound evaluate CIMT also a computed tomography calcium (CT‐CAC) scan. Results Carotid...
Evidence from imaging studies suggests a high prevalence of coronary artery disease (CAD) in patients with type 2 diabetes mellitus (T2DM). However, there are no criteria for initiating screening CAD this population. The current study investigated whether clinical and demographic characteristics can be used to predict significant T2DM.Computed tomography angiography (CTCA) laboratory assessments were performed 259 diagnosed T2DM attending clinics Northwest London, UK. Coronary calcium (CAC)...
The ear lobe crease (ELC) has been defined as a deep wrinkle that extends backwards from the tragus to auricle. It proposed ELC is predictor of coronary artery disease (CAD). In this review, we consider possible association between and CAD. Our aim systematically address all relevant evidence in field. There are many studies support an However, other did not find such association. A recent meta-analysis supports hypothesis could be marker several limitations raise doubts whether should accept link.
<h3>Objective</h3> To assess changes in metabolic risk factors and cancer-related growth associated with short-term abstinence from alcohol. <h3>Design</h3> Prospective, observational study. <h3>Setting</h3> Single tertiary centre. <h3>Participants</h3> Healthy subjects were recruited based on intention to: (1) abstain alcohol for 1 month (abstinence group), or (2) continue to drink (control group). Inclusion criteria baseline consumption >64 g/week (men) >48 (women). Exclusion known...
While vitamin D (vitD) deficiency is thought to contribute poor health in a variety of ways and should be corrected, there still concern about giving vitD supplements patients with history nephrolithiasis. The aim study the prevalence effect on stone risk cholecalciferol (vitD3) supplementation cohort idiopathic formers (ISF). We screened for urinary measures risk, comparing deficient (serum 25-OH ≤30 nmol/L; ≤12 ng/mL) insufficient (31–75 13–30 or replete (>75 >30 ng/mL); we investigated...