A5101644567- DNA and Biological Computing
- Advanced biosensing and bioanalysis techniques
- semigroups and automata theory
- Algorithms and Data Compression
- Machine Learning and Algorithms
- Diamond and Carbon-based Materials Research
- RNA and protein synthesis mechanisms
- Natural Language Processing Techniques
- Speech and dialogue systems
- Modular Robots and Swarm Intelligence
- Computability, Logic, AI Algorithms
- DNA and Nucleic Acid Chemistry
- Logic, programming, and type systems
- Cellular Automata and Applications
- Force Microscopy Techniques and Applications
- Semantic Web and Ontologies
- Logic, Reasoning, and Knowledge
- Magnetic properties of thin films
- Formal Methods in Verification
- Machine Learning in Bioinformatics
- Network Packet Processing and Optimization
- Genomics and Phylogenetic Studies
- Chemical Synthesis and Analysis
- Speech Recognition and Synthesis
- Service-Oriented Architecture and Web Services
University of Electro-Communications
2012-2024
Kyushu University
1994-2024
University of Fukui
2019-2023
The University of Tokyo
1989-2022
Keio University
2022
Osaka University
2007-2020
Kyoto Bunkyo University
2020
Kyoto University
2020
Kyoto University Institute for Chemical Research
2020
Kyoto Sangyo University
2006-2008
Abstract Atomic-sized fluorescent defects in diamond are widely recognized as a promising solid state platform for quantum cryptography and information processing. For these applications, single photon sources with high intensity reproducible fabrication methods required. In this study, we report novel color center diamond, composed of germanium (Ge) vacancy (V) named the GeV center, which has sharp strong photoluminescence band zero-phonon line at 602 nm room temperature. We demonstrate new...
ConspectusWhat we can call a molecular robot is set of devices such as sensors, logic gates, and actuators integrated into consistent system. The supposed to react autonomously its environment by receiving signals making decisions computation. Building system has long been dream scientists; however, despite extensive efforts, systems having all three functions (sensing, computation, actuation) have not realized yet.This Account introduces an ongoing research project that focuses on the...
Pancreatic cancer has one of the highest mortalities among all malignancies and there is an urgent need for new therapy. This might be achieved by resolving detailed biological mechanism, in this study we examined how pancreatic cells develop aggressive properties focusing on signalling through fibroblast growth factor (FGF)10 FGF receptor (FGFR)2, which play important roles organogenesis. Immunostaining tissues showed that FGFR2 was expressed cells, whereas FGF10 stromal surrounding cells....
The rapid progress of molecular nanotechnology has opened the door to robotics, which uses molecules as robot components. In order promote this new paradigm, Molecular Robotics Research Group was established in Systems and Information Division Society Instrument Control Engineers (SICE) 2010. group consists researchers from various fields including chemistry, biophysics, DNA nanotechnology, systems science challenging emerging field. Last year, proposed a research project focusing on it...
The feature extraction of human activity recognition (HAR) based on sensor data has been studied as a hand-crafted method. significant ability is key factor in improving the accuracy HAR. Recently, deep learning methods have employed for extraction. In this paper, we review previous studies HAR and discuss suitable models First, applied various convolutional neural networks to clarify effective architecture Afterward, developed advanced by embedding submodules, such self-attention recurrent...
Androgen receptor (AR)-targeting therapy induces oxidative stress in prostate cancer. However, the mechanism of induction by AR-targeting remains unclear. This study investigated therapy, with aim to develop novel therapeutics targeting induced therapy. Intracellular reactive oxygen species (ROS) was examined fluorescence microscopy and flow cytometry analysis. The effects silencing gene expression small molecule inhibitors on cytotoxic were quantitative real-time PCR cell proliferation...
Deep learning (DL) models for sensor-based human activity recognition (HAR) are still in their nascent stages compared with image recognition. HAR's inference is generally implemented on edge devices such as smartphones because of its secure privacy. However, lightweight DL HAR, while meeting the hardware limitations, lacking. In this study, using neural architecture search (NAS), we investigated an effective model that can be used smartphones. We designed multiple spaces type convolution,...
Abstract Tetraspanin CD81 is closely homologous in amino acid sequence with CD9. CD9 well known to be involved sperm–egg fusion, and has also been reported membrane fusion events. However, the function of as that remains unclear. Here, we report disruption mouse gene led a reduction fecundity female mice, CD81−/− eggs had impaired ability fuse sperm. Furthermore, demonstrated when were incubated sperm, some sperm penetrated into perivitelline space not yet undergone acrosome reaction,...
The leak-free DNA amplification reaction supplies a large quantity of single-stranded for directing molecular nanodevices in response to nucleic acid stimuli.
This paper presents an efficient algorithm for learning in the limit a special type of regular languages, called strictly locally testable languages from positive data, and its application to identifying protein /spl alpha/-chain region amino acid sequences. First, we present linear time that, given language, learns deterministic finite state automaton only data. provides one with practical method specific concept domain sequence analysis. We then describe several experimental results using...
Abstract The huge information storage capability of DNA and its ability to self‐assemble can be harnessed enable massively parallel computing in a small space. DNA‐based logic gates are designed that rely on strand displacement reactions; however, computation is slow due time‐consuming reassembly processes prone failure as susceptible degradation by nucleases under certain solution conditions. Here, it shown the presence cationic copolymer boosts speed gate operations involve multiple...
DNA strand displacement is an essential reaction in genetic recombination, biological processes, and nanotechnology. In particular, various nanodevices enable complicated calculations. However, it takes time before the output obtained, so acceleration of required for a rapid-response nanodevice. Herein, by using photo-crosslinking to accelerate this evaluated. The 3-cyanovinylcarbazole (CNV K) was accelerated at least 20 times, showing faster displacement. rate key factor through ultrafast...
Various artificial molecular devices, including some made of DNA or RNA, have been developed to date. The next step in this area research is develop an integrated system from such devices. A robot consists sensors, computers, and actuators, all reacts autonomously its environment by observing the environment, making decisions with performing actions upon environment. Molecular computers should thus be intelligent controllers robots. Such can naturally regarded as hybrid systems because...
From a biological motivation of the interactions between linear and circular DNA sequences, we propose new type splicing model called "circular H systems" show that they have same computational power as Turing machines. It is also shown there effectively exists universal system which can simulate any with terminal alphabet, strongly suggests feasible design for computer based on splicing.
This paper introduces a variety of analog computing elements utilizing dynamics DNA strand displacement reactions. In the proposed method, establishment functional relationship between concentrations inputs and those outputs at steady state is regarded as computation. We will propose versions an amplifier, adder, multiplier, divider constant gate, which are time responsive. Some further discussion be made toward construction controllers for molecular robots.
The authors are concerned with analysing formal linguistic properties of DNA sequences in which a number the language theoretic analysis on established by means computational methods. First, employing framework, consider kind evolutionary problem sequences, asking (1) how were initially created and then evolved (grew up) to be certain complexity, (2) what primitive constructs minimally required for process evolution. In terms concepts, present several results that provide their views these...