A5055197744- Bacterial Genetics and Biotechnology
- Bacterial biofilms and quorum sensing
- Vibrio bacteria research studies
- CRISPR and Genetic Engineering
- Fibroblast Growth Factor Research
- Oral microbiology and periodontitis research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- RNA and protein synthesis mechanisms
- Cell Image Analysis Techniques
- Alzheimer's disease research and treatments
- Bacteriophages and microbial interactions
- Genomics and Phylogenetic Studies
- 3D Printing in Biomedical Research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Viral Infectious Diseases and Gene Expression in Insects
- Antimicrobial Resistance in Staphylococcus
Princeton University
2017-2021
University of Michigan
2012-2016
Brunswick (United States)
1987
Edison (Italy)
1987
Staphylococcus aureus is a human commensal and pathogen that capable of forming biofilms on variety host tissues implanted medical devices. Biofilm-associated infections resist antimicrobial chemotherapy attack from the immune system, making these particularly difficult to treat. In order gain insight into environmental conditions influence S. biofilm development, we screened library small molecules for ability inhibit formation. This led finding polyphenolic compound tannic acid inhibits...
ABSTRACT Outer membrane protein (OMP) biogenesis in Escherichia coli is a robust process essential to the life of organism. It catalyzed by β-barrel assembly machine (Bam) complex, and number quality control factors, including periplasmic chaperones proteases, maintain integrity this trafficking pathway. Little known, however, about how proteases recognize degrade OMP substrates when compromised or whether different same substrate at distinct points In work, we use well-defined...
Abstract Bacteria can achieve a staggering diversity of cell shapes that promote critical functions like growth, motility, and virulence 1-4 . Previous studies suggested bacteria establish complex by co-opting the core machineries essential for elongation division 5,6 In contrast, we discovered two-protein module, CrvAB, curve autonomously major machinery forming dynamic, asymmetrically-localized structure in periplasm. CrvAB is curvature its native species, Vibrio cholerae , sufficient to...