A5073764164- Effects and risks of endocrine disrupting chemicals
- Ion channel regulation and function
- Lipoproteins and Cardiovascular Health
- Chronic Kidney Disease and Diabetes
- Free Radicals and Antioxidants
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Synthesis and Reactions of Organic Compounds
- Epilepsy research and treatment
- Receptor Mechanisms and Signaling
- Multicomponent Synthesis of Heterocycles
- Laser Applications in Dentistry and Medicine
- Tea Polyphenols and Effects
- Synthesis of Organic Compounds
- Phytochemicals and Antioxidant Activities
- Cancer, Lipids, and Metabolism
- Traditional Chinese Medicine Analysis
- Migraine and Headache Studies
- Heart Failure Treatment and Management
- Toxic Organic Pollutants Impact
- Agricultural and Food Sciences
- Neuroscience and Neuropharmacology Research
- Phytochemical and Pharmacological Studies
- Hops Chemistry and Applications
The Ohio State University Wexner Medical Center
2024-2025
The Ohio State University
2024-2025
Universidade Federal de São Carlos
2025
Charles University
2021-2024
Regular intake of polyphenol-rich food has been associated with a wide variety beneficial health effects, including the prevention cardiovascular diseases. However, parent flavonoids have mostly low bioavailability and, hence, their metabolites hypothesized to be bioactive. One these metabolites, 3-hydroxyphenylacetic acid (3-HPAA), formed by gut microbiota, was previously reported exert vasorelaxant effects ex vivo. The aim this study shed more light on effect in vivo, and elucidate...
Sudden unexpected death in epilepsy (SUDEP) is a fatal complication experienced by otherwise healthy patients. Dravet syndrome (DS) an inherited epileptic disorder resulting from loss of function the voltage-gated sodium channel, NaV 1.1, and associated with particularly high SUDEP risk. Evidence mounting that NaVs abundant brain also occur heart, suggesting very molecular mechanisms underlying could precipitate cardiac arrhythmias sudden death. Despite marked reduction 1.1 functional...
Abstract Objective In 2021, the US Food and Drug Administration issued a safety warning concerning lamotrigine use in patients with underlying cardiac disorders. This was based on vitro data that predicted class Ib antiarrhythmic activity for lamotrigine. Therefore, we investigated proarrhythmic potential of murine heart compared its effect flecainide. Methods Murine hearts were perfused clinically relevant concentrations 3.8 μg/mL (15 μmol·L −1 ) or flecainide .4 (1 ). Results Ex vivo...
Both pyridine and pyrano derivatives have been previously shown to possess biologically relevant activity. In this study, we report the incorporation of these two scaffolds into one molecule.The designed 3,3-dimethyl-6-oxopyrano[3,4-c]pyridines were synthesized by acylation enamine under Stork conditions followed condensation formed β-diketones with 2-cyanoacetamide. The structures compounds confirmed using a wide spectrum physico-chemical methods. Their antiplatelet, anticoagulant...