A5069722351- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Innovative Teaching Methods
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Urticaria and Related Conditions
- Multiple and Secondary Primary Cancers
- Renal cell carcinoma treatment
- Blood Coagulation and Thrombosis Mechanisms
- Autoimmune and Inflammatory Disorders Research
- Platelet Disorders and Treatments
- Venous Thromboembolism Diagnosis and Management
- Cancer-related gene regulation
- Cancer Genomics and Diagnostics
- Acute Ischemic Stroke Management
- Neurological Complications and Syndromes
- Immune Cell Function and Interaction
- Acute Myeloid Leukemia Research
- Histiocytic Disorders and Treatments
- Global Cancer Incidence and Screening
- Neutropenia and Cancer Infections
- Mast cells and histamine
- Epigenetics and DNA Methylation
- Economic and Financial Impacts of Cancer
- Lymphoma Diagnosis and Treatment
Icahn School of Medicine at Mount Sinai
2017-2024
Mount Sinai Beth Israel
2017
Albert Einstein College of Medicine
2016
Montefiore Medical Center
2008
Stony Brook University Hospital
1997
State University of New York
1997
Clinical and preclinical data demonstrate that altered pulmonary physiology (including increased inflammation, blood flow, airway resistance, hyper-reactivity) is an intrinsic component of Sickle Cell Disease (SCD) may contribute to excess SCD morbidity mortality. Inhaled corticosteroids (ICS), a safe effective therapy for inflammation in asthma, ameliorate the physiologic milieu SCD. With this single-center, longitudinal, randomized, triple-blind, placebo controlled trial we studied...
Abstract Factor XI (FXI) deficiency is an autosomal inherited, milder bleeding disorder that may predispose to a potential risk of life-threatening during childbirth or surgery. Unfortunately, data regarding obstetric and perioperative management this condition are scarce, with limited cases reviewed in the last decade. Therefore, present study aimed expand database identify factors associated increased risk. We performed retrospective chart review patients FXI who underwent other surgical...
e18521 Background: Leukemia consists of multiple diverse disorders which confer varying morbidities and an increased risk mortality. Iron deficiency anemia (IDA) is much more common, while non-malignant, has also been shown to have association with Despite the probability these two hematological conditions coexisting, interaction between them yet be closely studied. This retrospective cohort study aims help elucidate how IDA affects mortality in patients leukemia. Methods: Data was obtained...
In a patient diagnosed with histiocytic medullary reticulosis (HM), we examined immunocytes for their responsiveness towards known signaling molecules. Both the granulocytes and monocytes were found to exhibit high level of spontaneous activation (96% compared normal cells 7%; P < 0.001). These could not be downregulated when exposed morphine. Following treatment doxorubicin cyclophosphamide, still exhibited activation. They responded morphine exposure in vitro cell rounding becoming...
1544 Background: Renal medullary carcinoma (RMC) is a rare and aggressive epithelial neoplasm seen in patients (pts) with sickle cell trait (SCT). Disease often advanced at presentation prognosis of RMC presumed to be poor; though large studies are lacking due the rarity disease most data based on isolated case reports. Data molecular profiling limited, needed chemorefractiveness reported cases. Montefiore Medical Center serves population anemia we set out study clinical epidemiology our...
BACKGROUND:Sickle cell disease (SCD) is an autosomal recessive hereditary condition characterized by chronic hemolytic anemia and painful vaso-occlusive episodes. Homozygous sickle patients are at increased risk of morbidity mortality from malaria. Autoimmune (AIHA) secondary to, or in the setting of, malarial infection rare. In our case, concurrence Plasmodium falciparum parasitemia AIHA led to severe with extensive packed red blood transfusion requirement. The patient’s underlying SCD also...