A5100333888- interferon and immune responses
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Obstructive Sleep Apnea Research
- Cytokine Signaling Pathways and Interactions
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Voice and Speech Disorders
- NF-κB Signaling Pathways
- Cell Adhesion Molecules Research
- Hepatitis C virus research
- Complement system in diseases
- T-cell and B-cell Immunology
- Inflammasome and immune disorders
- Biological Stains and Phytochemicals
- Pediatric health and respiratory diseases
- Gastrointestinal Tumor Research and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Toxin Mechanisms and Immunotoxins
- Plant Virus Research Studies
- Polyamine Metabolism and Applications
- Studies on Chitinases and Chitosanases
- Atherosclerosis and Cardiovascular Diseases
- Inflammatory mediators and NSAID effects
- Phagocytosis and Immune Regulation
Asan Medical Center
2018-2023
Ulsan College
2018-2023
University of Ulsan
2018-2023
Kyung Hee University Dental Hospital
2022
Yonsei University
2018
Avixgen (South Korea)
2015
Pusan National University
2012
Pohang University of Science and Technology
2007-2010
Korea Institute of Radiological and Medical Sciences
2007
Sejong University
2003
RIG-I senses intracellular virus-specific nucleic acid structures and initiates an antiviral response that induces interferon (IFN) production, which, in turn, activates the transcription of to increase protein levels. Upon poly(I:C) stimulation, however, levels did not correlate with expression patterns transcripts. When ISG15 conjugation system was overexpressed, conjugated cellular unconjugated form decreased. The ISGylation reduced both basal virus-induced IFN promoter activity. Levels...
Wall teichoic acid (WTA) of Staphylococcus aureus is a major cell envelope-associated glycopolymer that key molecule in promoting colonization during S. infection. The complement system plays role the opsonization and clearance pathogens. We recently reported WTA functions as ligand human serum mannose-binding lectin (MBL), recognition pathway. Intriguingly, MBL adults does not bind to because an inhibitory effect anti-WTA-IgG. In this study, anti-WTA-IgG was purified homogeneity using...
Abstract ISG15 is a ubiquitin-like molecule whose expression induced by type I IFN (IFN-α/β) or in response to virus bacterial infection. conjugation of target proteins was reported play critical roles the regulation antiviral responses. restricts replication hepatitis C (HCV). However, molecular mechanism IFN-α/β that inhibits HCV not clear yet. In current study, we demonstrated inhibited overexpression and ISG15-conjugation enzymes subgenomic replicon cells. Among various nonstructural...
Distant metastasis represents the primary cause of cancer-associated death. Pulmonary is most frequently seen in many cancers, largely driven by lung inflammation. Components from tumor or recruited leukocytes are known to facilitate formation. However, contribution target site-specific host factor poorly understood. Here, we show that developmental endothelial locus-1 (DEL-1), an anti-inflammatory abundant and down-regulated inflammatory insults, protects melanoma independently development...
Uncontrolled activation of transforming growth factor (TGF)-β results in a wide range pathologic conditions. Therapeutic interventions to regulate TGF-β signaling during fibrosis have been developed but the effectiveness is still limited. Here, we show that developmental endothelial locus-1 (Del-1) ameliorates mice by inhibiting αv integrin-mediated TGF-β. Del-1 bound αvβ6 integrin, an important activator TGF-β, and inhibited binding integrin latency-associated peptide (LAP), thereby...
Antiatherosclerotic effects of ethanolic extracts Artemisia princeps Pampanini cv. Sajabal (ESJ) were investigated in low-density lipoprotein receptor deficient (LDLR(-/-)) mice. The Western diet-induced high levels total cholesterol and triglyceride similar the ESJ control groups. However, circulating oxidized LDL was significantly decreased group (p < 0.05). also markedly aortic expression intercellular adhesion molecule-1 (ICAM-1), vascular cell (VCAM-1), tumor necrosis factor-alpha...
Abstract Caspase-1 is an inflammatory caspase that controls the activation and secretion of cytokines, IL-1β IL-18. We observed cellular levels retinoic acid-inducible gene-I (RIG-I) were enhanced when pan-caspase inhibitor Z-VAD-fmk or caspase-1-specific Z-WEHD-fmk blocked activity. Overexpression caspase-1 reduced RIG-I inhibited RIG-I-mediated signaling Enzymatic activity was necessary to control RIG-I, although it not a substrate proteolytic cleavage by caspase-1. physically interacted...
Abstract The lateral cephalogram in orthodontics is a valuable screening tool on undetected obstructive sleep apnea (OSA), which can lead to consequences of severe systematic disease. We hypothesized that deep learning-based classifier might be able differentiate OSA as anatomical features cephalogram. Moreover, since the imaging devices used by each hospital could different, there need overcome modality difference radiography. Therefore, we proposed learning model with knowledge...
The human immunodeficiency virus type-1 (HIV-1) nucleocapsid protein (NC) is an essential and multifunctional involved in multiple stages of the viral life cycle such as reverse transcription, integration proviral DNA, especially genome RNA packaging. For this reason, it has been considered attractive target for development new anti-HIV drugs. Although a number inhibitors NC have reported thus far, search NC-specific functional inhibitor(s) with good antiviral activity continues. In study,...
Here we report a new chemical inhibitor against HIV-1 with novel structure and mode of action. The inhibitor, designated as A1836, inhibited replication virus production 50% inhibitory concentration (<TEX>$IC_{50}$</TEX>) <TEX>$2.0{\mu}M$</TEX> in an MT-4 cell-based cytopathic protection antiviral assay, while its cytotoxic (<TEX>$CC_{50}$</TEX>) was much higher than <TEX>$50{\mu}M$</TEX>. Examination the effect A1836 on vitro reverse transcriptase (RT) integrase showed that neither were...
11532 Background: Although the benefits of resection for focally progressive advanced gastrointestinal stromal tumors (GISTs) during imatinib (IM) treatment have been suggested, those over IM alone not proven. We compared clinical outcomes plus dose escalation or maintenance (S group) with (NS in patients (pts) GIST following focal progression (FP) standard doses IM. Methods: Between April 2003 and October 2016, 98 pts histologically documented initially metastatic distant recurrent GISTs...
Immunity is the defense against external invasion and breakdown of immune system that causes various diseases. In this study, immunomodulatory function brown rice fermented vinegar (FV) was investigated using a cyclophosphamide (CP)-induced immunosuppression model. in vitro splenocytes were treated with CP to induce measure splenocyte proliferation natural killer (NK) cell activity. Here, 5 mg/kg orally administered animal model, then 0.5 ml/kg, 1 2 ml/kg FV each. The results from studies...
<b>Background:</b> The chitinase 3-like 1 (CHI3L1), has been demonstrated its requirement for optimal allergen sensitization and Th2 inflammation in various chronic inflammatory diseases including asthma. But, the role of CHI3L1 airway induced by respiratory viruses not proved yet. purpose this study is to figure out relationship between followed syncytial virus (RSV) infection. <b>Methods:</b> We measured YKL-40 human nasopharyngeal aspirates (NPA) from hospitalized children presenting with...
Abstract Undetected obstructive sleep apnea (OSA) can lead to consequences of severe systematic disease. The lateral cephalogram in orthodontics is a valuable screening tool. We hypothesized that deep learning-based classifier might be able differentiate as anatomical features humans do not recognize cephalogram. Moreover, since the imaging devices used by each hospital could different, various modalities radiography need overcome real clinical practice. Therefore, we proposed knowledge...