A5102817472- Pluripotent Stem Cells Research
- Tissue Engineering and Regenerative Medicine
- CRISPR and Genetic Engineering
- Congenital heart defects research
- Artificial Intelligence in Healthcare and Education
- Surgical Simulation and Training
- Cardiac, Anesthesia and Surgical Outcomes
- RNA modifications and cancer
- Cancer Mechanisms and Therapy
- Fungal Infections and Studies
- Chromatin Remodeling and Cancer
- RNA Research and Splicing
- Cardiac Fibrosis and Remodeling
- Ethics and Social Impacts of AI
- Cancer-related molecular mechanisms research
- Anatomy and Medical Technology
- Poxvirus research and outbreaks
- Diverse Scientific Research Studies
- Renin-Angiotensin System Studies
- Pancreatitis Pathology and Treatment
- Acute Lymphoblastic Leukemia research
- Flow Measurement and Analysis
- Hospital Admissions and Outcomes
- Healthcare Operations and Scheduling Optimization
- Gallbladder and Bile Duct Disorders
University of Pennsylvania
2024
Boston Children's Hospital
2023
Boston University
2022
Baylor College of Medicine
2014-2021
Johns Hopkins University
2018-2020
Sidney Kimmel Comprehensive Cancer Center
2020
University of Baltimore
2018
Sanjay Gandhi Post Graduate Institute of Medical Sciences
2018
Dr. Ram Manohar Lohia Institute of Medical Sciences
2017
Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital
2014
Long noncoding RNAs (lncRNAs) are commonly dysregulated in tumors, but only a handful known to play pathophysiological roles cancer. We inferred lncRNAs that dysregulate cancer pathways, oncogenes, and tumor suppressors (cancer genes) by modeling their effects on the activity of transcription factors, RNA-binding proteins, microRNAs 5,185 TCGA tumors 1,019 ENCODE assays. Our predictions included hundreds candidate onco- tumor-suppressor lncRNAs) whose somatic alterations account for...
Abstract Generative artificial intelligence (AI) has the potential to both exacerbate and ameliorate existing socioeconomic inequalities. In this article, we provide a state-of-the-art interdisciplinary overview of impacts generative AI on (mis)information three information-intensive domains: work, education, healthcare. Our goal is highlight how could worsen inequalities while illuminating may help mitigate pervasive social problems. information domain, can democratize content creation...
The occurrence of a functional intracellular renin-angiotensin system (RAS) has emerged as new paradigm. Recently, we and others demonstrated synthesis ANG II in cardiac myocytes vascular smooth muscle cells that was dramatically stimulated high glucose conditions. Cardiac fibroblasts significantly contribute to diabetes-induced diastolic dysfunction. objective the present study determine existence RAS its role extracellular matrix deposition. Neonatal rat ventricular were serum starved...
Somatic inactivating mutations of ARID1A, a SWI/SNF chromatin remodeling gene, are prevalent in human endometrium-related malignancies. To elucidate the mechanisms underlying how ARID1A deleterious mutation contributes to tumorigenesis, we establish genetically engineered murine models with Arid1a and/or Pten conditional deletion endometrium. Transcriptomic analyses on endometrial cancers and precursors derived from these mouse show close resemblance uterine endometrioid carcinomas. We...
Generative artificial intelligence, including chatbots like ChatGPT, has the potential to both exacerbate and ameliorate existing socioeconomic inequalities. In this article, we provide a state-of-the-art interdisciplinary overview of probable impacts generative AI on four critical domains: work, education, health, information. Our goal is warn about how could worsen inequalities while illuminating directions for using resolve pervasive social problems. in workplace can boost productivity...
The stem cell factor spalt-like transcription 4 (SALL4) plays important roles in normal hematopoiesis and also leukemogenesis. We previously reported that SALL4 exerts its effect by recruiting epigenetic factors such as DNA methyltransferases DNMT1 lysine-specific demethylase 1 (LSD1/KDM1A). Both of these proteins are critically involved mixed lineage leukemia (MLL)-rearranged (MLL-r) leukemia, which has a very poor clinical prognosis. Recently, been further linked to the functions MLL...
Background Given known inefficiencies in reprogramming of fibroblasts into mature induced cardiomyocytes (iCMs), we sought to identify small molecules that would overcome these barriers cardiac cell transdifferentiation. Methods and Results We screened alternative combinations compounds impact using morphologic functional differentiation assays vitro. After screening 6 putative factors, found a combination the histone deacetylase inhibitor sodium butyrate, WNT ICG-001, growth regulator...
Research and development in artificial intelligence (AI) has been experiencing a resurgence over the past decade. The rapid growth evolution of AI approaches can leave one feeling overwhelmed confused about how these technologies will impact hepatopancreaticobiliary (HPB) surgery, obstacles to its clinical translation, role that HPB surgeons play accelerating AI’s ultimate impact. This review outlines some basic terminology current surgical AI, further translation influence future surgery.
Abstract Fibroblast reprogramming offers the potential for myocardial regeneration via in situ cell transdifferentiation. We explored a novel strategy leveraging endothelial plasticity to enhance efficiency. Rat cardiac cells and fibroblasts were treated with Gata4, Mef2c, Tbx5 (GMT) assess cardio-differentiation of these cells. The transdifferentiation factor ETV2 was transiently over-expressed followed by GMT treatment “trans-endothelial” cardio-differentiation. Endothelial generated more...
Cerebral aspergillosis mostly presents as single or multiple abscesses with vascular invasion in immunocompromised patients. A rare mass like tumoral form of cerebral has been described immunocompetent 22-year-old-male presented recurrent attacks complex partial seizures secondary generalization, headache, and blurring vision. Preoperative diagnosis a neoplasm was considered view solid mass-like enhancement. However, histopathological examination suggestive central nervous system...
Abstract Surgical Data Science is an emerging scientific discipline that applies advances in data science, machine learning and AI to harness the increasingly large amounts of surgical enable surgery [1–4]. collection for solutions involves both ingestion contingent (in case surgery—medical records, data, instrument medical images, from OR sensors video), as well intentionally collected annotations expert opinion describing data. This organized knowledge then used train models ultimately...
Transesophageal echocardiography (TEE) plays a pivotal role in cardiology for diagnostic and interventional procedures. However, using it effectively requires extensive training due to the intricate nature of image acquisition interpretation. To enhance efficiency novice sonographers reduce variability scan acquisitions, we propose novel ultrasound (US) navigation assistance method based on contrastive learning as goal-conditioned reinforcement (GCRL). We augment previous framework patient...
There is an urgent clinical need to develop new therapeutic approaches treat heart failure, but the biology of cardiovascular regeneration complex. A generation reprogramming technology involves trans-differentiating one adult somatic cell type directly into another. We reported previously that administration gene transfer vectors encoding Gata4 (G), Mef 2c (M) and Tbx5 (T), reprograms rat cardiac fibroblasts induced cardiomyocytes (iCMs) in vitro improves function myocardial infarction...
Background: Sall4 is an essential component in maintaining embryonic stem cell self-renewal and pluripotency. Given its functional protein level interaction with cardiac trans-differentiation factors Tbx5/Gata4, as well critical role modulating development, we hypothesized that may play important reprogramming. Material/Method: We conducted gain- loss- of function studies on neonatal adult fibroblast from both mouse rat. also evaluated infarcted rat heart. Results: Gata4/Mef2c/Tbx5 (GMT)...