A5047338443- Hepatitis C virus research
- RNA modifications and cancer
- Hepatitis B Virus Studies
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- HIV Research and Treatment
- Liver Disease Diagnosis and Treatment
- Animal Disease Management and Epidemiology
- Plant pathogens and resistance mechanisms
- Ferroptosis and cancer prognosis
- Rice Cultivation and Yield Improvement
- RNA regulation and disease
- Optical Systems and Laser Technology
- Aluminum Alloys Composites Properties
- Viral Infections and Immunology Research
- Calibration and Measurement Techniques
- Circadian rhythm and melatonin
- Wheat and Barley Genetics and Pathology
- Advanced Image Fusion Techniques
- Magnesium Alloys: Properties and Applications
- Remote-Sensing Image Classification
- Infrared Target Detection Methodologies
- Concrete and Cement Materials Research
- Plant nutrient uptake and metabolism
- Esophageal Cancer Research and Treatment
Jilian Technology Group (China)
2024
Shandong Special Equipment Inspection Institute
2024
Tongji University
2024
The University of Texas MD Anderson Cancer Center
2022-2023
Shandong Agricultural University
2022
Weatherford College
2021
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2020
Tsukuba International University
2018
University of Tsukuba
2018
Peking Union Medical College Hospital
2014
Abstract The coactivator associated arginine methyltransferase (CARM1) promotes transcription, as its name implies. It does so by modifying histones and chromatin bound proteins. We identified nuclear factor I B (NFIB) a CARM1 substrate show that this transcription utilizes coactivator. Biochemical studies reveal tripartite motif 29 (TRIM29) is an effector molecule for methylated NFIB. Importantly, NFIB harbors both oncogenic metastatic activities, often overexpressed in small cell lung...
Abstract Viruses evolve multiple ways to interfere with NF-κB signaling, a key regulator of innate and adaptive immunity. Enterovirus 71 (EV71) is one primary pathogens that cause hand-foot-mouth disease. Here, we identify RelA(p65) as novel binding partner for EV71 2C protein from yeast two-hybrid screen. By interaction IPT domain p65, reduces the formation heterodimer p65/p50, predominant form NF-κB. We also show picornavirus family proteins inhibit activation associate p65 IKKβ. Our...
ABSTRACT Phosphatidylinositol 4-phosphate (PI4P) is well known to be upregulated during hepatitis C virus (HCV) replication. The role of PI4 kinases in HCV has been extensively investigated. Whether the PI4P phosphatase Sac1 altered by remains unclear. Here, we identified ARFGAP1 a novel host factor for We further show that interacts with and inhibits elevation induced NS5A abrogated when coatomer protein I (COPI) pathway inhibited. also found an interaction between ARFGAP1. Furthermore,...
Gene families contain genes that come from the same ancestor and have similar sequences structures. They perform certain specific functions within among different species. Currently, there is no complete process or platform for rapid analysis of plant gene families. In this study, a comprehensive query families, Plant Family Platform (PlantGF), was constructed. The composed four main parts: Search, Tools, Statistics Auxiliary. A total 2 909 580 family members were identified 138 species in...
Esophageal squamous cell carcinoma (ESCC) is a common human malignancy worldwide. The tumorigenesis mechanism in ESCC unclear.To explore potential therapeutic targets for ESCC, we analyzed 3 microarray datasets (GSE20347, GSE38129, and GSE67269) derived from the gene expression omnibus (GEO) database. Then, GEO2R tool was used to screen out differently expressed genes (DEGs) between normal tissue. Gene ontology function kyoto encyclopedia of genomes pathway enrichment analysis were performed...
Mg-5Al-2Zn-0.2Mn alloys with Y contents of 0, 0.2, 0.3, 0.4, and 0.5 wt.% were prepared by gravity casting. The influence content on magnesium alloys' fine texture corrosion behavior was studied detections. experimental results indicate that the metal structure without mainly consists matrix phase continuous or semi-continuous β-phase Mg<sub>17</sub>(Al, Zn)<sub>12</sub> distributed in grain boundary matrix. addition disrupted continuity βMg<sub>17</sub> (Al, Zn)<sub>12</sub>. When...
The optical remote sensors carried by the Jilin-1 KF02 series satellites have an imaging resolution better than 0.5 m and a width of 150 km. There are radiometric problems, such as stripe noise, vignetting, inter-slice chromatic aberration, in their raw images. In this paper, relative correction method based on temperature normalization is proposed for response characteristics structural splicing cameras. Firstly, model effect sensor output established to correct variation digital number...
Color distortion is a common issue in Jilin-1 KF01 series satellite imagery, phenomenon caused by the instability of sensor during imaging process. In this paper, we propose data-driven method to correct color imagery. Our involves three key aspects: color-distortion simulation, model design, and post-processing refinement. First, investigate causes algorithms simulate phenomenon. By superimposing simulated patterns onto clean images, construct datasets comprising large number paired images...
Abstract Previously, it was found that the hepatitis C virus NS5A interacted with ACBD3 in a genotype‐dependent manner. However, region responsible for association is not clear. Domain I of identified as critical binding. By comparing differences amino acids domain from different genotypes NS5A, key potentially corresponded to affinity NS5A‐ACBD3 interaction. The findings only revealed associates but they also shed mechanistic light on how associated
In construction of Pingxiang Dominant Genic Male Sterile Rice (PDGMSR) sterile gene mapping population, we found some reported maintainer lines shown the fertility restoration ability.Thus, this study systemly analyzed separation F 1 , 2 and 3 populations crosses between PDGMSR lines.We observed that progenies from sib-crosses male-sterile plant fertile were always segregated in a ratio to fertile.The could be when kept high temperature during stage young panicle development, selfed gave...
Abstract Background: Our work focuses on the role of METTL21A, a member little studied seven β-strand family candidate lysine methyltransferases (KMTs), and its in regulation pancreatic ductal adenocarcinoma (PDAC) development. Using meta-analysis publicly available gene expression datasets, we found that METTL21A is significantly downregulated PDAC versus normal tissue reduced predicts poor patient survival. Thus, there are intriguing correlations connecting to pathogenesis; however, date,...