A5112702129- Metal complexes synthesis and properties
- Advanced biosensing and bioanalysis techniques
- Autophagy in Disease and Therapy
- Immune Cell Function and Interaction
- Cancer, Hypoxia, and Metabolism
- Polyamine Metabolism and Applications
- Immune cells in cancer
- Cancer-related molecular mechanisms research
- Drug Transport and Resistance Mechanisms
- Geological and Geophysical Studies
- Lanthanide and Transition Metal Complexes
- Epigenetics and DNA Methylation
- Ferrocene Chemistry and Applications
- Nanoparticle-Based Drug Delivery
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Cancer Research and Treatments
- Immunotherapy and Immune Responses
- Nanocluster Synthesis and Applications
- Circular RNAs in diseases
- Sleep and Wakefulness Research
- Retinal Diseases and Treatments
- TGF-β signaling in diseases
- Galectins and Cancer Biology
- X-ray Spectroscopy and Fluorescence Analysis
Renji Hospital
2025
Shanghai Jiao Tong University
2025
Harbin Institute of Technology
2020-2025
Tsukuba International University
2018-2025
University of Tsukuba
2018-2025
Hebei Medical University
2024-2025
Second Hospital of Hebei Medical University
2024-2025
Henan University
2018-2024
Henan University Huaihe Hospital and Huaihe Clinical Institute
2024
China National Nuclear Corporation
2024
The NLRP3 (NLR [NOD-like receptor] family, pyrin domain containing 3) inflammasome is an important driver of atherosclerosis. Our previous study shows that chaperone-mediated autophagy (CMA), one the main lysosomal degradative process, has a regulatory role in lipid metabolism macrophages. However, whether regulated by CMA, and CMA atherosclerosis remains unclear.To determine regulation atherosclerosis.The expression marker, LAMP-2A (lysosome-associated membrane protein type 2A), was first...
Piwi–piRNA (Piwi-interacting RNA) ribonucleoproteins (piRNPs) enforce retrotransposon silencing, a function critical for preserving the genome integrity of germ cells. The molecular functions most factors that have been genetically implicated in primary piRNA biogenesis are still elusive. Here we show MOV10L1 exhibits 5′-to-3′ directional RNA-unwinding activity vitro and point mutation abolishes this causes failure vivo. We demonstrate selectively binds precursor transcripts is essential...
A highly selective and sensitive near-infrared (NIR) fluorescence probe (Cy-NO2) for imaging nitroreductase was developed successfully applied to investigating the relationship between epithelial–mesenchymal transitions (EMTs) in tumour progression intracellular hypoxic level.
Platinum-drug-based chemotherapy in clinics has achieved great success clinical malignancy therapy. However, unpredictable off-target toxicity and the resulting severe side effects treatment are still unsolved problems. Although metabolic glycan labeling-mediated tumor-targeted therapy been widely reported, less selective labeling vivo limited its wide application. Herein, a novel probe of B–Ac3ManNAz that is regulated by reactive oxygen species tumor cells introduced to enhance recognition...
Emerging evidence suggests that the tumor microenvironment plays a critical role in regulating cancer stem cells (CSCs) and progression through both autocrine paracrine signaling. Elevated production of bone morphogenetic proteins (BMPs) from human ovarian stroma has been shown to increase CSC proliferation growth. Here, we report Lin28, cell factor, binds BMP4 mRNA epithelial carcinoma cells, thereby promoting expression at post-transcriptional level. As co-expression Lin28 Oct4 (another...
Maternal obesity is associated with adverse pregnancy outcomes. It negatively affects IVF/ICSI outcomes and offspring health. However, it unclear whether waist-hip ratio (WHR) has an impact on of in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) cycles. A retrospective cohort study screened 943 patients who underwent treatment between February June 2020 Shanghai, China, 828 were finally included the analyses. The body weight, height, waist circumference hip measured...
<title>Abstract</title> <bold>Background:</bold> This study explores the causal relationships between five major lipids, 249 circulating metabolites, and four diabetic retinopathy (DR) outcomes: overall DR, background severe proliferative DR (PDR). We aim to identify plasma proteins that mediate these effects, offering insights into potential therapeutic targets. <bold>Methods:</bold> conducted metabolome-wide Mendelian randomization (MR) analyses assess associations outcomes. Multivariable...
Cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder (CDD) is an X-linked rare neurodevelopmental associated with severe sleep disturbances. However, little known about the mechanisms underlying disturbances in CDD patients. Here, we employed electroencephalogram (EEG) recording to characterize sleep–wake behaviors and EEG activity male CDKL5-deficient mice. We found that young adult middle-aged Cdkl5 knockout (KO) mice recapitulated phenotypes patients CDD, including difficulties...
This study explores the causal relationships between five major lipids, 249 circulating metabolites, and four diabetic retinopathy (DR) outcomes: overall DR, background severe proliferative DR (PDR). We aim to identify plasma proteins that mediate these effects, offering insights into potential therapeutic targets. conducted metabolome-wide Mendelian randomization (MR) analyses assess associations outcomes. Multivariable MR (MVMR) proteome-wide mediated (two-step MR) were performed ensure...
The long-lasting application of representative herbicide atrazine (ATR) has given rise to the accumulation its residues in groundwater. To investigate impact long-term ATR use on groundwater safety, and metabolites, desethylatrazine (DEA), deisopropylatrazine (DIA) hydroxyatrazine (HA) were monitored top soil at major corn growing region Qian'an Gongzhuling Jilin Province, China. target compounds analyzed by UPLC-MS/MS. limits detection (LODs) ATR, DEA, DIA, HA 0.5, 5, 0.5 ng L−1 0.33, 3.3,...
Diverse platinum drug candidates have been designed to improve inhibitory potency and overcome resistance for orthotopic tumors. However, the antimetastatic properties rarely reported. We herein report that homospermidineplatin (4a), a polyamine-Pt(IV) prodrug, can potently inhibit tumor growth in situ reverse cisplatin as expected, more importantly, 4a displays remarkably elevated activity vivo (65.7%), compared those of (27.0%) oxaliplatin (19.6%). The underlying molecular mechanism...
Increasing studies have revealed that circular RNAs (circRNAs) contribute to gastric cancer (GC) progression. The RNA ribosomal protein L15 (circ-RPL15) is involved in chronic lymphocytic leukemia. However, its expression and functions GC remain elusive. of circ-RPL15 human tissues adjacent normal tissues, cell lines (MGC-803, BGC-823, MGN-28, SGC-7901, AGS) mucosal epithelial line (GES-1) were detected by RT-PCR. relationship between level clinical-pathological indicators also analyzed....
Physiological characteristics of human malignancies are increased glycolysis and overexpression glucose transporters (GLUTs). 18Flurodeoxyglucose-positron emission tomography (FDG-PET) has successfully developed as clinical modality for the diagnosis staging many cancers based on Warburg effect. To leverage this transporter mediated metabolic disparity between normal malignant cells, in current report, protected de-protected glucose, mannose, galactose, rhamnose, maltose lactose-conjugated...
Platinum-drugs based chemotherapy in clinic increases the potency of tumor cells to produce M2 macrophages, thus leading poor anti-metastatic activity and immunosuppression. Lysosome metabolism is critical for cancer cell migration invasion, but how it promotes antitumor immunity tumours macrophages poorly understood underlying mechanisms are elusive. The present study aimed explore a synergistic strategy dismantle immunosuppressive microenvironment metallodrugs discovery by using herent...
High expression of programmed death-ligand-1 (PD-L1) in hepatocellular carcinoma (HCC) cells usually inhibits the proliferation and functions T cells, leading to immune suppression tumor microenvironment. However, very little has been described regarding mechanism PD-L1 overexpression HCC cells. In present study, we found epidermal growth factor (EGF) stimulation promoted mRNA protein Inhibition receptor (EGFR) could reverse EGF-induced protein. Subsequently, also observed that...
Platinum (Pt) drugs have developed rapidly in clinical applications because of their broad and highly effective antitumor effects. In recent years, with the rapid development immunotherapy, Pt-based agents gained new challenges opportunities. Since discovery pharmacological effects immunotherapy tumor microenvironment regulation, research into Pt has progressed to multi-ligand multi-functional precursors own shortcomings been further highlighted. With rise combination therapy, started move...
Naphthalimides, such as amonafide and mitonafide in clinical trials, have been developed antitumor agents for orthotopic tumor. However, the serious side effects cancer patients limit their applications. Herein, a new class of polyamine-based naphthalimide conjugates 5a-5c, 7a-7b, 11a-11b with without alkylation distant nitrogen polyamine chain were synthesized mechanism was determined. Compared amonafide, dinitro-naphthalimide conjugate 5c 4,3-cyclopropyl motif preferentially accumulates...
A new series of naphthalimide platinum(IV) compounds with dual DNA damage mechanism were designed, synthesized and evaluated for antitumor activities. The could combine cause via fragment. Then the platinum(II) complexes released in reductive microenvironment would remarkable secondary lesions. Some title exhibit good activities are great potential overcoming drug resistance cisplatin. Furthermore, effectively HSA by electrostatic force, which influence distribution bioactivities vivo....