A5032580142- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Immune Response and Inflammation
- Toxin Mechanisms and Immunotoxins
- Pharmacological Effects of Natural Compounds
- T-cell and B-cell Immunology
- Single-cell and spatial transcriptomics
- Lung Cancer Research Studies
- Atherosclerosis and Cardiovascular Diseases
- Ginseng Biological Effects and Applications
- MicroRNA in disease regulation
- Traditional Chinese Medicine Analysis
- Mycobacterium research and diagnosis
- NF-κB Signaling Pathways
- Cannabis and Cannabinoid Research
- PARP inhibition in cancer therapy
- Immune cells in cancer
- Acute Kidney Injury Research
- Polyomavirus and related diseases
- Peptidase Inhibition and Analysis
- Diet and metabolism studies
- Cell Image Analysis Techniques
- Animal Disease Management and Epidemiology
- Lattice Boltzmann Simulation Studies
University Hospital Bonn
2020-2024
Animal Science Research Institute
2024
Wuhan Third Hospital
2018-2023
Ludwig-Maximilians-Universität München
2013-2023
State Key Laboratory of Genetic Engineering
2022
Fudan University
2022
Linyi People's Hospital
2020
Sun Yat-sen University
2019
Fifth Affiliated Hospital of Sun Yat-sen University
2019
Jinan University
2016
Atherosclerotic plaques form in the inner layer of arteries triggering heart attacks and strokes. Although T cells have been detected atherosclerosis, tolerance dysfunction as a disease driver remains unexplored. Here we examine checkpoints atherosclerotic plaques, artery tertiary lymphoid organs lymph nodes mice burdened by advanced via single-cell RNA sequencing paired with cell antigen receptor sequencing. Complex patterns deteriorating peripheral were observed being most pronounced...
Undeniably, cancer immunotherapies have expanded the spectrum of treatment, however, some patients do not respond to immunotherapies. This scenario is no different for lung cancer, whose two main types, non-small cell (NSCLC) and small (SCLC), still pose a serious clinical challenge. Adoptive T-cell therapies (ATC), which primarily include cytokine-induced killer (CIK) therapy, chimeric antigen receptor (CAR T-cell) therapy γδ-T-cell strengthen patient's immune system in combating cancer....
Background: Elabela (ELA) is a newly identified endogenous ligand of apelin receptor (APJ) which has been confirmed to be implicated in the pathogenesis hypertension. Previous experiments have revealed critical role ELA eliciting vasodilation and lowering blood pressure. However, plasma levels hypertensive patients its relationship with vascular function not investigated.Method: Thirty-one essential hypertension (EH) 31 age-matched healthy subjects as controls were recruited study. Plasma...
Introduction A multitude of findings from cell cultures and animal studies are available to support the anti-cancer properties cannabidiol (CBD). Since CBD acts on multiple molecular targets, its clinical adaptation, especially in combination with cancer immunotherapy regimen remains a serious concern. Methods Considering this, we extensively studied effect cytokine-induced killer (CIK) approach using non-small lung (NSCLC) cells harboring diverse genotypes. Results Our analysis showed that,...
Ethnopharmacological relevance Danggui Buxue decoction (DBD) is a traditional Chinese herbal formula. According to the theory of medicine, combination Astragali Radix (AR) and Angelica sinensis (AS) classic prescription tonifying qi enriching blood. DBD has functions hematopoietic, immune enhancement inflammation inhibition, usually used treat blood deficiency symptoms. Aim study Cyclophosphamide (CY) can inhibit humoral cellular immunity, leading overall disorder body, resulting in...
Increasing studies have revealed that circular RNAs (circRNAs) contribute to gastric cancer (GC) progression. The RNA ribosomal protein L15 (circ-RPL15) is involved in chronic lymphocytic leukemia. However, its expression and functions GC remain elusive. of circ-RPL15 human tissues adjacent normal tissues, cell lines (MGC-803, BGC-823, MGN-28, SGC-7901, AGS) mucosal epithelial line (GES-1) were detected by RT-PCR. relationship between level clinical-pathological indicators also analyzed....
Cigarette smoke-triggered inflammation is important in the pathophysiology of chronic obstructive pulmonary disease, and involves overexpression many proinflammatory genes. Transcription factors regulating expression inflammatory mediators may play a key role characterizing disease. To observe alterations function, pathological changes lung tissues, detect transcriptional factors, mice were exposed to 30 days cigarette smoke. Pulmonary function was measured by pressure sensors, observed...
Cytokine-induced killer (CIK) cells are heterogeneous, major histocompatibility complex (MHC)-unrestricted T lymphocytes that have acquired the expression of several natural (NK) cell surface markers following addition interferon gamma (IFN-γ), OKT3 and interleukin-2 (IL-2). Treatment with CIK demonstrates a practical approach in cancer immunotherapy limited, if any, graft versus host disease (GvHD) toxicity. been proposed tested many clinical trials patients by autologous, allogeneic or...
Cancer heterogeneity poses a serious challenge concerning the toxicity and adverse effects of therapeutic inhibitors, especially when it comes to combinatorial therapies that involve multiple targeted inhibitors. In particular, in non-small cell lung cancer (NSCLC), number studies have reported synergistic drug combinations preclinical models, while they were only partially successful clinical setup, suggesting those alternative strategies (with genetic background immune response) should be...
Abstract To determine if nuclear factor-κB (NF-κB) activation may be a key factor in lung inflammation and respiratory dysfunction, we investigated whether NF-κB can blocked by intratracheal administration of decoy oligodeoxynucleotides (ODNs), ODN-mediated inhibition prevent smoke-induced inflammation, improve pathological alteration the small airways parenchyma long-term mouse model system. We also detected changes transcriptional factors. In vivo, transfection efficiency ODNs to alveolar...
Natural killer group 2D (NKG2D) receptor plays a pivotal role in cytokine-induced (CIK) cell-mediated cytotoxicity against malignancies, and the expression of NKG2D ligands might allow targets to be more susceptible CIK destruction. In this study, we investigated synergistic effects cells antitumor activity antibody-mediated inhibition MICA/B shedding. This monoclonal antibody (7C6) has been previously shown able specifically target a3 domain on tumor cells, resulting increase cell surface...
The flow cytometry-based assay has been increasingly used to assess the cell-mediated cytotoxicity since 1980s due its advantages over conventional radioactive 51 Cr release (CRA), such as higher sensitivity at single-cell level and nonradioactivity. basic principle of this is usage two dyes, one nontoxic dye for labeling targets or effector cells distinguish from another, viability discrimination dead live cells. Due problem spontaneous leakage dye, concern about cross-staining not yet...
The clinical utility of immune checkpoint inhibitors, such as programmed cell death protein 1 (PD‑1) and death‑ligand (PD‑L1) inhibitors used alone or in combination with other therapies, is currently gaining attention. In this particular scenario, the inclusion cytokine‑induced killer (CIK) cells has proven to be a novel therapeutic approach. CIK have shown anticancer activity various hematopoietic malignancies, but their defined cytotoxicity B‑cell non‑Hodgkin lymphoma (B‑NHL) remains...
Nowadays, cardiovascular illnesses are among the leading causes of death in world. Thus, many studies have been performed to diagnose and prevention these diseases. Studies show that computational hemodynamic method (CHD) is a very effective control prevent progression this type disease. In paper, impression five non-Newtonian viscosity models (nNVMs) on cerebral blood vessels (CBV) investigated by CHD. simulation, flow supposed steady, laminar, incompressible, non-Newtonian. The parameters...
Background:GPC5 rs2352028 is associated with the risk of lung cancer, but its relationship cancer prognosis unclear. Materials & methods: The authors collected blood samples from 888 patients and used a Cox proportional hazards model to analyze association between GPC5 polymorphism rs2352028. Results:GPC5 C > T was better prognosis. Patients CT genotype had longer overall survival than those CC genotype. Additionally, older early-stage + TT lower death Conclusion:GPC5 may play protective...
Abstract A multitude of findings from the cell cultures and animal studies are available to support anti-cancer properties cannabinoids cannabidiol (CBD). Since CBD acts on multiple molecular targets, its clinical adaptation, especially in combination with cancer immunotherapy regimen remains a serious concern. Considering this, herein, we extensively studied effect cytokine-induced killer (CIK) cells approach using non-small lung (NSCLC) harboring diverse genotypes. Our analysis showed...