Uyen Nguyen
A5101975097- Surgical site infection prevention
- Peptidase Inhibition and Analysis
- Trypanosoma species research and implications
- Healthcare cost, quality, practices
- Cellular Mechanics and Interactions
- Ethics in Clinical Research
- Cell Adhesion Molecules Research
- Synthesis and Biological Evaluation
- Patient-Provider Communication in Healthcare
- Glaucoma and retinal disorders
- Interprofessional Education and Collaboration
- Force Microscopy Techniques and Applications
- Trauma and Emergency Care Studies
- Enhanced Recovery After Surgery
- Bone fractures and treatments
- Biochemical and Molecular Research
- Reconstructive Surgery and Microvascular Techniques
- Protein Tyrosine Phosphatases
- COVID-19 and healthcare impacts
- Orthopedic Infections and Treatments
- Retinal Development and Disorders
- Retinal and Optic Conditions
- Health Policy Implementation Science
- Nematode management and characterization studies
- Mental Health and Patient Involvement
University of California, Davis
2019-2020
University of California, San Diego
2012
Max Planck Institute of Molecular Physiology
2008
How mechanical signals are transmitted in the cardiac myocyte is poorly understood. In this study, we produced a tamoxifen-inducible mouse model which β1 integrin could be reduced specifically adult cardiomyocyte, so that function of assessed postnatal and mechanically stressed heart. The expression was to 35% control levels, but remained normal at baseline. With aortic constriction, knockout mice survived had blunted hypertrophic response. Integrin myocytes, contrast controls, showed...
To characterize the evolution and structure of soft drusen in aged rhesus macaques using vivo multimodal retinal imaging ex histologic ultrastructural analyses as a nonhuman primate model early age-related macular degeneration (AMD).Multimodal including fundus photography, spectral domain optical coherence tomography (SD-OCT), autofluorescence (FAF) were used to track individual lesions 20 (mean age 23.3 ± 2.7 years) with drusenoid over 2 years, followed by semithin analysis transmission...
The present work describes the synthesis of 22 new imidazopyridine analogues arising from medicinal chemistry optimization at different sites on molecule. Seven and 12 compounds exhibited an in vitro EC50 ≤ 1 μM against Trypanosoma cruzi (T. cruzi) brucei brucei) parasites, respectively. Based promising results activity (EC50 < 100 nM), cytotoxicity, metabolic stability, protein binding, pharmacokinetics (PK) properties, compound 20 was selected as a candidate for vivo efficacy studies. This...
The risk of developing a surgical site infection after extremity fracture repair is nearly 5 times greater than in most elective orthopedic procedures. For all procedures, it standard practice to prepare the operative with an antiseptic solution; however, there limited evidence guide choice solution used for repair.To compare effectiveness iodophor vs chlorhexidine solutions reduce infections and unplanned fracture-related reoperations patients who underwent repair.The PREP-IT (Program...
Ende des Transfers: Ausgehend von der Struktur Pepticinnamin E wurden Inhibitoren Rab-Geranylgeranyltransferase (RabGGTase) mit zellulärer Aktivität entwickelt. Die erste Kristallstruktur Enzyms im Komplex einem Inhibitor wird vorgestellt (siehe die Inhibitors und seine Positionierung aktiven Zentrum Enzyms). Ergebnisse sind wichtig für chemisch-biologische Studien zur Prenylierung zum vesikulären Transport Beteiligung RabGGTase an Entstehung Krankheiten. Supporting information for this...
In response to the COVID-19 pandemic, many hospital systems were forced reduce operating room capacity and reallocate resources. The outcomes of these policies on care injured patients maintenance emergency services have not been adequately reported.To evaluate whether pandemic was associated with delays in urgent fracture surgery beyond national time-to-surgery benchmarks.This retrospective cohort study used data collected Program Randomized Trials Evaluate Preoperative Antiseptic Skin...
Cluster randomized crossover trials are often faced with a dilemma when selecting an optimal model of consent, as the traditional obtaining informed consent from participant's before initiating any trial related activities may not be suitable. We describe our experience engaging patient advisors to identify for PREP-IT trials. This paper also examines surrogate measures success selected consent.The program consists two multi-center cluster that engaged determine consent. Patient and...
On the Cover: New data reveal a novel mechanism by which p47 phox-/-mice develop extensive, systemic alternative macrophage activation, with phox identified as previously unrecognized regulator of cell fate choice.Shown is immunofluorescence for intracellular mannose receptor protein (red) in lung phox-/-mouse 3 days post Listeria monocytogenes infection; nuclei are stained DAPI (blue).Original magnification, ϫ400.