A5000462132- Bone health and osteoporosis research
- Pain Mechanisms and Treatments
- Advanced Glycation End Products research
- Wnt/β-catenin signaling in development and cancer
- Cancer-related gene regulation
- Botulinum Toxin and Related Neurological Disorders
- Nerve injury and regeneration
- Bone health and treatments
- Bone Metabolism and Diseases
- Medical Imaging Techniques and Applications
- Muscle activation and electromyography studies
- Biochemical effects in animals
- Neuropeptides and Animal Physiology
- Axon Guidance and Neuronal Signaling
- Infrared Thermography in Medicine
- Adipose Tissue and Metabolism
- Spine and Intervertebral Disc Pathology
- Speech and Audio Processing
- Hearing Loss and Rehabilitation
- Endoplasmic Reticulum Stress and Disease
- Signaling Pathways in Disease
- Peptidase Inhibition and Analysis
- Stress Responses and Cortisol
- Musculoskeletal pain and rehabilitation
- Phonetics and Phonology Research
Washington University in St. Louis
2019-2025
Saint Louis University
2019
Linde (United States)
2019
Type 2 diabetes (T2D) is associated with higher fracture risk, despite normal or high bone mineral density. We reported that formation genes ( SOST and RUNX2 ) advanced glycation end-products (AGEs) were impaired in T2D. investigated Wnt signaling regulation its association AGEs accumulation strength T2D from tissue of 15 21 non-diabetic postmenopausal women undergoing hip arthroplasty. Bone histomorphometry revealed a trend low mineralized volume (T2D 0.249% [0.156–0.366]) vs subjects...
ABSTRACT Nerves in bone play well-established roles pain and vasoregulation have been associated with progression of skeletal disorders, including osteoporosis, fracture, arthritis, tumor metastasis. However, isolation the region-specific mechanisms underlying these relationships is limited by our lack quantitative methods for neuroskeletal analysis precise maps innervation. To overcome limitations, we developed an optimized workflow imaging axons around bone, validation Baf53b-Cre concert...
Diabetic patients have a high risk of developing skeletal diseases accompanied by diabetic peripheral neuropathy (DPN). In this study, we isolated the role DPN in disease with global and conditional knockout models sterile-α TIR-motif-containing protein-1 (Sarm1). SARM1, an NADase highly expressed nervous system, regulates axon degeneration upon range insults, including DPN. Global Sarm1 prevented DPN, but not disease, male mice type 1 diabetes (T1D). Female wild also developed bone without...
Mechanical loading is required for bone health and results in skeletal adaptation to optimize strength. Local nerve axons, particularly within the periosteum, may respond load-induced biomechanical biochemical cues. However, their role anabolic response remains controversial. We hypothesized that spatial alignment of periosteal nerves with sites formation would clarify this relationship. To achieve this, we developed RadialQuant, a custom tool histomorphometry. Tibiae control neurectomized...
Type 2 diabetes (T2D) is associated with higher fracture risk, despite normal or high bone mineral density. We reported that formation genes ( SOST and RUNX2 ) advanced glycation end-products (AGEs) were impaired in T2D. investigated Wnt signaling regulation its association AGEs accumulation strength T2D from tissue of 15 21 non-diabetic postmenopausal women undergoing hip arthroplasty. Bone histomorphometry revealed a trend low mineralized volume (T2D 0.249% [0.156–0.366]) vs subjects...
Abstract Inflammatory cytokine production and de novo neurovascularization have been identified in painful, degenerated intervertebral discs (IVDs). However, the temporal trajectories of these key pathoanatomical features, including cascade inflammatory chemokines neo-vessel neurite infiltration, their associations with IVD degeneration, remain relatively unknown. Investigating this process caudal mouse enables opportunity to study tissue-specific response without confounding signaling from...
Background/Aims Bioelectric nerve stimulation (eStim) is an emerging clinical paradigm that can promote regeneration after trauma, including within the context of diabetes. However, its ability to prevent onset diabetic peripheral neuropathy (DPN) has not yet been evaluated. Beyond itself, DPN emerged as a potential contributor sarcopenia and bone disease; thus, we hypothesized eStim could serve strategy simultaneously neural musculoskeletal health in Methods To address this question,...
Type 2 diabetes (T2D) is associated with higher fracture risk, despite normal or high bone mineral density. We reported that formation genes ( SOST and RUNX2 ) Advanced Glycation End-products (AGEs) were impaired in T2D. investigated Wnt signaling regulation its association AGEs accumulation strength T2D from tissue of 15 21 non-diabetic postmenopausal women undergoing hip arthroplasty. Bone histomorphometry revealed a trend low mineralized volume [(T2D 0.249% (0.156-0.366) vs subjects...
Mechanical loading is required for bone health and results in skeletal adaptation to optimize strength. Local nerve axons, particularly within the periosteum, may respond load-induced biomechanical biochemical cues. However, their role anabolic response remains controversial. We hypothesized that spatial alignment of periosteal nerves with sites formation would clarify this relationship. To achieve this, we developed RadialQuant, a custom tool histomorphometry. Tibiae control neurectomized...
This protocol details the quantification of basic bone parameters including area, area fraction, periosteal perimeter, etc., dynamic indices formation using calcein double labels, and length, density, branching nerve endings present in long cross-sections imaged by confocal microscopy.
Abstract Type 2 diabetes (T2D) is associated with higher fracture risk, despite normal or high bone mineral density. We reported that formation genes ( SOST and RUNX2 ) Advanced Glycation End-products (AGEs) were impaired in T2D. investigated Wnt signaling regulation its association AGEs accumulation strength T2D from tissue of 15 21 non-diabetic postmenopausal women undergoing hip arthroplasty. Bone histomorphometry revealed a trend low mineralized volume [(T2D 0.249% (0.156-0.366) vs...
Abstract Background/Aims Bioelectric nerve stimulation (eStim) is a novel clinical paradigm that can promote regeneration after trauma, including within the context of diabetes. However, its ability to prevent onset diabetic peripheral neuropathy (DPN) has not yet been evaluated. Beyond itself, DPN emerged as potential contributor sarcopenia and bone disease; thus, we hypothesized eStim could serve strategy simultaneously neural musculoskeletal health in Methods To address this question, an...
Type 2 diabetes (T2D) is associated with higher fracture risk, despite normal or high bone mineral density. We reported that formation genes (SOST and RUNX2) advanced glycation end-products (AGEs) were impaired in T2D. Thus, we investigated Wnt signaling regulation its association AGEs accumulation obtained tissue from 15 T2D 21 non-diabetic postmenopausal women undergoing hip arthroplasty. Bone histomorphometry revealed a trend of low mineralized volume showed gene expression agonists LEF-1...
ABSTRACT Nerves in bone play well-established roles pain and vasoregulation have been associated with progression of skeletal disorders including osteoporosis, fracture, arthritis tumor metastasis. However, isolation the region-specific mechanisms underlying these relationships is limited by our lack comprehensive maps innervation. To overcome this, we mapped sympathetic adrenergic sensory peptidergic axons within limb two strains mice (B6 C3H). In periosteum, were related to surrounding...
Nerves in bone play well-established roles pain and vasoregulation have been associated with the progression of skeletal disorders including osteoporosis, fracture, arthritis tumor metastasis. However, isolation region-specific mechanisms underlying these relationships is limited by our lack precise maps innervation. We developed an optimized workflow for imaging nerve axons around bone, resulting novel, comprehensive sympathetic adrenergic sensory peptidergic within full length femur tibia...