A5045256396- Bone health and osteoporosis research
- Adipose Tissue and Metabolism
- Bone Metabolism and Diseases
- Advanced Glycation End Products research
- Wnt/β-catenin signaling in development and cancer
- Diet and metabolism studies
- Muscle metabolism and nutrition
- Biochemical effects in animals
- Musculoskeletal pain and rehabilitation
- Cancer-related gene regulation
- Metabolism, Diabetes, and Cancer
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Osteoarthritis Treatment and Mechanisms
- Adipokines, Inflammation, and Metabolic Diseases
- Myofascial pain diagnosis and treatment
- Bariatric Surgery and Outcomes
- Total Knee Arthroplasty Outcomes
- Spine and Intervertebral Disc Pathology
- Pharmacology and Obesity Treatment
- Orthopaedic implants and arthroplasty
- Dental Implant Techniques and Outcomes
- Hip disorders and treatments
- Bone health and treatments
- Vitamin D Research Studies
- Neurological and metabolic disorders
Università Campus Bio-Medico
2019-2024
Campus Bio Medico University Hospital
2023
Università Cattolica del Sacro Cuore
2021
Istituti di Ricovero e Cura a Carattere Scientifico
2021
ABSTRACT Increased circulating sclerostin and accumulation of advanced glycation end-products (AGEs) are two potential mechanisms underlying low bone turnover increased fracture risk in type 2 diabetes (T2D). Whether the expression sclerostin-encoding SOST gene is altered T2D, whether it associated with AGEs or regulation other formation-related genes unknown. We hypothesized that accumulate upregulated bones from subjects leading to downregulation forming (RUNX2 osteocalcin) impaired...
Type 2 diabetes (T2D) is associated with higher fracture risk, despite normal or high bone mineral density. We reported that formation genes ( SOST and RUNX2 ) advanced glycation end-products (AGEs) were impaired in T2D. investigated Wnt signaling regulation its association AGEs accumulation strength T2D from tissue of 15 21 non-diabetic postmenopausal women undergoing hip arthroplasty. Bone histomorphometry revealed a trend low mineralized volume (T2D 0.249% [0.156–0.366]) vs subjects...
Physical exercise favors weight loss and ameliorates articular pain function in patients suffering from osteoarthritis. Irisin, a myokine released upon muscle contraction, has demonstrated to yield anabolic effects on different cell types. This study aimed investigate the effect of irisin human osteoarthritic chondrocytes (hOAC) vitro. Our hypothesis was that would improve hOAC metabolism proliferation. Cells were cultured growing media then exposed either phosphate-buffered saline (control...
Oxidative stress, a key mediator of cardiovascular disease, metabolic alterations, and cancer, is independently associated with menopause obesity. Yet, among postmenopausal women, the correlation between obesity oxidative stress poorly examined. Thus, in this study, we compared states women or without Body composition was assessed via DXA, while lipid peroxidation total hydroperoxides were measured patient’s serum samples thiobarbituric-acid-reactive substances (TBARS) derivate-reactive...
<h3>Objectives</h3> To assess the efficacy of a single intradiscal injection allogeneic bone marrow mesenchymal stromal cells (BM-MSCs) versus sham placebo in patients with chronic low back pain (LBP). <h3>Methods</h3> Participants were randomised prospective, double-blind, controlled study to receive either or 20 million BM-MSC, between April 2018 and December 2022. The first co-primary endpoint was rate responders defined by improvement Visual Analogue Scale (VAS) for at least 20% mm,...
Introduction: Adipose tissue is widely exploited in regenerative medicine thanks to its trophic properties, mainly based on the presence of adipose-derived stromal cells. Numerous devices have been developed promote clinical use, leading introduction one-step surgical procedures obtain minimally manipulated adipose derivatives. However, only a few studies compared their biological properties. This study aimed characterize micro-fragmented (MAT) and nanofat (NAT) obtained with two different...
Type 2 diabetes (T2D) is associated with higher fracture risk, despite normal or high bone mineral density. We reported that formation genes ( SOST and RUNX2 ) advanced glycation end-products (AGEs) were impaired in T2D. investigated Wnt signaling regulation its association AGEs accumulation strength T2D from tissue of 15 21 non-diabetic postmenopausal women undergoing hip arthroplasty. Bone histomorphometry revealed a trend low mineralized volume (T2D 0.249% [0.156–0.366]) vs subjects...
Abstract Bone fragility is a recognized complication of type 2 diabetes mellitus (T2DM), increasing patient morbidity. Thus, the development an effective intervention to prevent diabetic bone urgently needed. As lifestyle represents option for management, it may have impact on health. While studies shown beneficial effect dietary fiber in T2DM its health still unclear. we investigated high-fiber diet and glucose control men women with T2DM. Forty-five patients (HbA1c: 6.5% ± 0.49%, age: 74...
Overweight represents a major issue in contemporary orthopaedic practice. A higher body mass index (BMI) is associated with an increase of perioperative complications following several procedures, particular total hip arthroplasty (THA). However, the influence overweight on THA surgical time controversial. In this study, we investigated association between BMI and analyzing role patients' comorbidities. We conducted retrospective study 748 patients undergoing at our institutions 2017 2018....
The introduction of CAD/CAM and the development zirconia-based restorations have allowed clinicians to use less expensive materials faster manufacturing procedures. purpose study was analyze differences, in terms mechanical biological complication, multiunit zirconia fixed dental prosthesis (FPDs) on posterior implants produced using a digital workflow. Method Materials. This retrospective investigation, patients treated with screw-retained monolithic or partial veneer FPDs were selected....
The impact of obesity on clinical outcomes following joint replacement procedures is resounding. Therefore, multiple strategies to achieve a substantial weight loss before surgery are needed in obese patients. aim the study was test effect fiber-enriched high carbohydrate (FEHC) diet reduction body and pain elderly patients undergoing total hip arthroplasty (THA). Sixty-one candidates for THA were included our study. Prior procedure, participants have been randomly assigned 3-month...
Diabetes represents a challenge in implant therapy because hyperglycemia may negatively affect bone regeneration, directly compromising clinical outcomes and increasing failures. The aim of this retrospective study is to analyse the prognostic significance HbA1c levels patients undergoing placement associated with horizontal guided regeneration. Thirty-four were divided into 3 groups according their levels: nondiabetic normoglycemic (HbA1c < 5.7%), hyperglycemic 6.5%), controlled diabetic...
The dipeptidyl peptidase 3 (Dpp3) is a ubiquitous zinc-dependent aminopeptidase, participating in the activation or degradation of signaling peptides and Keap1−Nrf2 antioxidant pathway. absence Dpp3 knockout mouse model causes increased osteoclast activity, altered osteogenic function, sustained oxidative stress bone tissue, loss. We aimed to assess association activity with fragility postmenopausal osteoporosis impact denosumab on enzymatic activity. conducted two-phase study including 69...
Tendinopathy is one of the most common musculoskeletal disorders with significant repercussions on quality life and sport activities. Physical exercise (PE) considered first-line approach to treat tendinopathy due renowned mechanobiological effects tenocytes. Irisin, a recently identified myokine released during PE, has been recognized for several beneficial towards muscle, cartilage, bone, intervertebral disc tissues. The aim this study was evaluate irisin human primary tenocytes (hTCs) in...
Abstract Type 2 diabetes (T2D) is associated with higher fracture risk, despite normal or high bone mineral density. We reported that formation genes ( SOST and RUNX2 ) Advanced Glycation End-products (AGEs) were impaired in T2D. investigated Wnt signaling regulation its association AGEs accumulation strength T2D from tissue of 15 21 non-diabetic postmenopausal women undergoing hip arthroplasty. Bone histomorphometry revealed a trend low mineralized volume [(T2D 0.249% (0.156-0.366) vs...
Type 2 diabetes (T2D) is associated with higher fracture risk, despite normal or high bone mineral density. We reported that formation genes ( SOST and RUNX2 ) Advanced Glycation End-products (AGEs) were impaired in T2D. investigated Wnt signaling regulation its association AGEs accumulation strength T2D from tissue of 15 21 non-diabetic postmenopausal women undergoing hip arthroplasty. Bone histomorphometry revealed a trend low mineralized volume [(T2D 0.249% (0.156-0.366) vs subjects...