A5017605378- Bone health and osteoporosis research
- Diabetes and associated disorders
- Diabetes Management and Research
- Pancreatic function and diabetes
- Bone Metabolism and Diseases
- Obesity, Physical Activity, Diet
- Metabolism, Diabetes, and Cancer
- Bone health and treatments
- Wnt/β-catenin signaling in development and cancer
- COVID-19 Clinical Research Studies
- Vitamin D Research Studies
- Diet and metabolism studies
- Advanced Glycation End Products research
- Diabetes Treatment and Management
- COVID-19 and healthcare impacts
- Nutritional Studies and Diet
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Rheumatoid Arthritis Research and Therapies
- Pancreatitis Pathology and Treatment
- Eating Disorders and Behaviors
- Monoclonal and Polyclonal Antibodies Research
- Biochemical effects in animals
- Cancer-related gene regulation
- Mesenchymal stem cell research
- Growth Hormone and Insulin-like Growth Factors
San Raffaele University of Rome
2023-2025
Campus Bio Medico University Hospital
2015-2025
Università Campus Bio-Medico
2012-2023
Queen Mary University of London
2012-2018
William Harvey Research Institute
2013-2016
University of London
2014
Introduction Food preferences are influenced by various factors, such as culture, age, and gender. The relationship between food tastes, meal preferences, eating habits has been studied extensively in recent years; however, research on gender differences these fields still needs to be addressed. aim of this study was investigate through self-administered questionnaires a large Italian population sample. Methods online survey included questions habits, sport involvement. Results results the...
Background: Gender differences in metabolic response to lifestyle interventions remain poorly explored. This study aimed evaluate the impact of a six-month Mediterranean diet (MD) intervention combined with regular physical activity on parameters overweight adults. Methods: A prospective cohort was conducted an obesity clinic Rome, Italy, involving adults (BMI ≥ 25 kg/m2) motivated improve their lifestyle. Participants (n = 205; 107 men and 98 women) self-selected into groups (aerobic,...
Abstract Objectives Hypoxia is an important factor in many aspects of stem‐cell biology including their viability, proliferation, differentiation and migration. We evaluated whether low oxygen level (2%) affected human adipose tissue mesenchymal (h AT ‐ MSC ) phenotype, population growth, apoptosis, necrosis adipogenic osteogenic potential. Materials methods h s from four donors were cultured growth medium under either normoxic or hypoxic conditions for 7 days then transferred to study...
Although there is an evidence of correlation between irisin and osteoporotic fractures, previous studies have not elucidated the relationship either lean or fat mass. The main aim this study to investigate body composition in postmenopausal women with osteoporosis impact levels on fragility vertebral fractures.In cross-sectional study, 36 overweight subjects affected by at least one fracture confirmed X-ray morphometry nonosteoporotic were enrolled. Serum measured using competitive ELISA. We...
Dipeptidyl peptidase 4 (DPP4), also known as cluster of differentiation 26 (CD26), is a serine exopeptidase expressed ubiquitously in several tissues, including but not limited to lung, kidney, liver, gut, and immune cells. The question has been raised on whether DPP4 modulation or inhibition may prevent infection and/or progression the COVID-19. A docked complex model SARS-CoV-2 spike glycoprotein proposed, showing large interface between proteins proposing close similarity with other...
ABSTRACT Increased circulating sclerostin and accumulation of advanced glycation end-products (AGEs) are two potential mechanisms underlying low bone turnover increased fracture risk in type 2 diabetes (T2D). Whether the expression sclerostin-encoding SOST gene is altered T2D, whether it associated with AGEs or regulation other formation-related genes unknown. We hypothesized that accumulate upregulated bones from subjects leading to downregulation forming (RUNX2 osteocalcin) impaired...
Obese subjects with coronavirus disease 2019 (COVID-19) are at increased risk of requiring critical care (1), suggesting that excess body fat associates greater severity. BMI does not discriminate between and lean mass poorly reflects distribution. Cardiometabolic diseases systemic inflammation, two conditions associated visceral adiposity, also linked to COVID-19 severity fatality (1,2). The aim this study was assess the relationship abdominal distribution We hypothesized adipose tissue...
Introduction This study investigates the interplay between body composition, dietary patterns, and physical activity across genders, focusing on gender-specific differences in food preferences eating behaviors. Understanding these interactions is crucial for developing targeted nutritional lifestyle interventions. Methods A cross-sectional was conducted with 1,333 participants (58.7% female, 41.3% male), aged 18–65 years. Participants were categorized into tertiles based their fat mass to...
Type 2 diabetes (T2D) is associated with higher fracture risk, despite normal or high bone mineral density. We reported that formation genes ( SOST and RUNX2 ) advanced glycation end-products (AGEs) were impaired in T2D. investigated Wnt signaling regulation its association AGEs accumulation strength T2D from tissue of 15 21 non-diabetic postmenopausal women undergoing hip arthroplasty. Bone histomorphometry revealed a trend low mineralized volume (T2D 0.249% [0.156–0.366]) vs subjects...
This cross-sectional study analyses differences in dietary habits, taste preferences, variety of protein sources and body composition (BC) profiles among individuals following omnivorous, flexitarian, lacto-ovo-vegetarian pescatarian diets. Furthermore, it assesses the correlations between these patterns various sports, classified by exercise intensity, relation to BC parameters. The analysed eating habits data 1342 participants aged 18–65 years, into four diet groups based on their 7-day...
Gender differences in dietary patterns and physical activity are known to influence metabolic health, but research exploring these using principal component analysis (PCA) is limited. This study aims identify distinct of eating behaviour, body composition between men women, order develop tailored interventions. A cross-sectional was conducted on 2,509 adults attending a health centre. Data habits, were collected by means questionnaires bioimpedance analysis. PCA used behaviour activity....
Gender differences in dietary habits, physical activity and body composition are key determinants of health disease risk. Although these well documented, their variation across age groups remains poorly explored. This study examines gender-specific patterns eating behaviours, sport preferences metrics, with the aim providing evidence for tailored public interventions. A cross-sectional was conducted on 2,276 participants (1,349 females 927 males) aged 18–75 years. Recruitment combined an...
Type II collagen (CII) posttranslationally modified by reactive oxygen species (ROS-CII) that are present in the inflamed joint is an autoantigen rheumatoid arthritis (RA). The aim of this study was to investigate potential use anti-ROS-CII autoantibodies as a biomarker RA.CII exposed oxidants joint. Autoreactivity ROS-CII assessed enzyme-linked immunosorbent assays synovial fluid (SF) and serum samples obtained from patients during various phases RA. This group included disease-modifying...
Coronavirus 2019 disease (COVID-19) mostly adversely affects the elderly, a population at higher risk for low serum 25-hydroxyvitamin D (25(OH)D) levels. In this viewpoint, we highlight well-known musculoskeletal properties of vitamin D, which are particularly relevant in context COVID-19, suggesting further potential benefits through extra-skeletal effects. Maintaining optimal 25(OH)D is crucial to prevent falls, frailty and fractures elderly patients, with activity levels due lockdown, or...
Obesity is a global health problem with significant chronic disease risks. This study examined gender differences in eating behaviour, body composition, frequency and time of hunger an Italian cohort obesity (BMI ≥ 30) to inform gender-specific management strategies.
Abstract Purpose Bone formation is impaired in both type 1 diabetes and 2 (T2D), whereas sclerostin, an antagonist of bone formation, increased T2D only. No data are available on latent autoimmune adults (LADA), that may clinically resemble at diagnosis. We evaluated serum sclerostin turnover markers LADA compared with those whether metabolic syndrome (MetS) affects or LADA. Methods This cross-sectional study included 98 patients 89 from the Action Non Insulin Requiring Autoimmune Diabetes...
We have shown that autoimmunity to insulin in type 1 diabetes may result from neoepitopes induced by oxidative post-translational modifications (oxPTM). Antibodies specific oxPTM-insulin (oxPTM-INS-Ab) are present most newly diagnosed individuals with and more common than autoantibodies native insulin. In this study, we investigated whether oxPTM-INS-Ab before clinical onset of diabetes, evaluated the ability identify children progressing diabetes.We used serum samples collected...
Oxidative stress, a key mediator of cardiovascular disease, metabolic alterations, and cancer, is independently associated with menopause obesity. Yet, among postmenopausal women, the correlation between obesity oxidative stress poorly examined. Thus, in this study, we compared states women or without Body composition was assessed via DXA, while lipid peroxidation total hydroperoxides were measured patient’s serum samples thiobarbituric-acid-reactive substances (TBARS) derivate-reactive...
It is unclear which vitamin D status optimal for bone health. In this study, we aimed to assess cutoffs of 25-hydroxyvitamin (25OHD) derived by the literature (20, 25, or 30 ng/mL) in relation turnover and mineral density (BMD). Serum 25OHD, PTH, osteocalcin, alkaline phosphatase, C-telopeptide were measured 274 consecutive postmenopausal women. BMD lumbar spine (L1–L4) femoral neck also evaluated. 50 patients had normal BMD, while 124 osteopenia 100 osteoporosis. 37.6%, 56.2%, 70.8%...