A5008131992- Bone health and osteoporosis research
- Wnt/β-catenin signaling in development and cancer
- Advanced Glycation End Products research
- Cancer-related gene regulation
- Biochemical effects in animals
- Bone Metabolism and Diseases
- Pain Mechanisms and Treatments
- Neuropeptides and Animal Physiology
- Pancreatic function and diabetes
- Cannabis and Cannabinoid Research
- Spaceflight effects on biology
- Birth, Development, and Health
- Diabetes and associated disorders
- Vitamin D Research Studies
- Diabetes Management and Research
- Sleep and Wakefulness Research
- Apelin-related biomedical research
- Liver Disease Diagnosis and Treatment
- Bone health and treatments
- Fatty Acid Research and Health
- Diet, Metabolism, and Disease
- Eicosanoids and Hypertension Pharmacology
Università Campus Bio-Medico
2021-2024
Frequentis (Germany)
2023
European Brain Research Institute
2021
Type 2 diabetes (T2D) is associated with higher fracture risk, despite normal or high bone mineral density. We reported that formation genes ( SOST and RUNX2 ) advanced glycation end-products (AGEs) were impaired in T2D. investigated Wnt signaling regulation its association AGEs accumulation strength T2D from tissue of 15 21 non-diabetic postmenopausal women undergoing hip arthroplasty. Bone histomorphometry revealed a trend low mineralized volume (T2D 0.249% [0.156–0.366]) vs subjects...
Type 2 diabetes (T2D) is associated with higher fracture risk, despite normal or high bone mineral density. We reported that formation genes ( SOST and RUNX2 ) advanced glycation end-products (AGEs) were impaired in T2D. investigated Wnt signaling regulation its association AGEs accumulation strength T2D from tissue of 15 21 non-diabetic postmenopausal women undergoing hip arthroplasty. Bone histomorphometry revealed a trend low mineralized volume (T2D 0.249% [0.156–0.366]) vs subjects...
Space-related stressors such as microgravity are associated with cellular and molecular alterations of the immune inflammatory homeostasis that have been linked to disorders astronauts suffer from during their missions. Most research past 30 years has consistently established innate adaptive cells represent a target microgravity, which leads defective or dysfunctional activation, well an altered ability produce soluble mediators—e.g., cytokines/chemokines bioactive lipids—that altogether...
Abstract Resolution of inflammation is the cellular and molecular process that protects from widespread uncontrolled restores tissue function in aftermath acute immune events. This orchestrated by specialized pro‐resolving mediators (SPM), a class bioactive lipids able to reduce activation promote removal debris apoptotic cells macrophages. Although SPMs are lipid has been best studied for its role facilitating resolution self‐limited inflammation, number other signals, including...
Abstract Type 2 diabetes (T2D) is associated with higher fracture risk, despite normal or high bone mineral density. We reported that formation genes ( SOST and RUNX2 ) Advanced Glycation End-products (AGEs) were impaired in T2D. investigated Wnt signaling regulation its association AGEs accumulation strength T2D from tissue of 15 21 non-diabetic postmenopausal women undergoing hip arthroplasty. Bone histomorphometry revealed a trend low mineralized volume [(T2D 0.249% (0.156-0.366) vs...
Type 2 diabetes (T2D) is associated with higher fracture risk, despite normal or high bone mineral density. We reported that formation genes ( SOST and RUNX2 ) Advanced Glycation End-products (AGEs) were impaired in T2D. investigated Wnt signaling regulation its association AGEs accumulation strength T2D from tissue of 15 21 non-diabetic postmenopausal women undergoing hip arthroplasty. Bone histomorphometry revealed a trend low mineralized volume [(T2D 0.249% (0.156-0.366) vs subjects...
Type 2 diabetes (T2D) and obesity (OB) are associated with chronic low-grade inflammation increased fracture risk. In vitro studies showed that induces bone erosion inhibits formation by increasing Wnt canonical pathway inhibitors. However, the impact of on regulation quality in T2D OB remains unclear. To this end, we studied 63 postmenopausal women (age >65 years) undergoing hip replacement for osteoarthritis. Among these women, 19 had (HbA1c 6.8±0.79%; BMI 29.9±5.2 kg/m2), 17 but they...
Type 2 diabetes (T2D) and obesity (OB) are associated with chronic low-grade inflammation increased fracture risk. In vitro studies showed that induces bone erosion inhibits formation by increasing Wnt canonical pathway inhibitors. However, the impact of on regulation quality in T2D OB remains unclear. To this end, we studied 63 postmenopausal women (age >65 years) undergoing hip replacement for osteoarthritis. Among these women, 19 had (HbA1c 6.8±0.79%; BMI 29.9±5.2 kg/m2), 17 but they...
Type 2 diabetes (T2D) and obesity (OB) are associated with chronic low-grade inflammation increased fracture risk. In vitro studies showed that induces bone erosion inhibits formation by increasing Wnt canonical pathway inhibitors. However, the impact of on regulation quality in T2D OB remains unclear. To this end, we studied 63 postmenopausal women (age >65 years) undergoing hip replacement for osteoarthritis. Among these women, 19 had (HbA1c 6.8±0.79%; BMI 29.9±5.2 kg/m2), 17 but they...
Type 2 diabetes (T2D) is associated with higher fracture risk, despite normal or high bone mineral density. We reported that formation genes (SOST and RUNX2) advanced glycation end-products (AGEs) were impaired in T2D. Thus, we investigated Wnt signaling regulation its association AGEs accumulation obtained tissue from 15 T2D 21 non-diabetic postmenopausal women undergoing hip arthroplasty. Bone histomorphometry revealed a trend of low mineralized volume showed gene expression agonists LEF-1...
Type 1 diabetes (T1D) is a globally rising autoimmune condition. Genetics, viral infections, and environmental factors contribute to T1D. Comprehending these factors, along with the underlying pathophysiological mechanisms, gives rise concept of distinct “endotypes” within disease, paving way for enhanced strategies in prevention early intervention. This review highlights importance understanding multifaceted characteristics context T1D, providing comprehensive analysis its epidemiology risk...