A5051046557- Mitochondrial Function and Pathology
- Adipose Tissue and Metabolism
- Endoplasmic Reticulum Stress and Disease
- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- ATP Synthase and ATPases Research
- Nitric Oxide and Endothelin Effects
- Fatty Acid Research and Health
- Birth, Development, and Health
- Cancer-related molecular mechanisms research
- Signaling Pathways in Disease
- Drug Transport and Resistance Mechanisms
- Metabolism and Genetic Disorders
- Brain Metastases and Treatment
- Adenosine and Purinergic Signaling
- MicroRNA in disease regulation
- Peroxisome Proliferator-Activated Receptors
- Lipid metabolism and biosynthesis
- Genetic Neurodegenerative Diseases
- Circular RNAs in diseases
- Diet, Metabolism, and Disease
- Redox biology and oxidative stress
- Amyotrophic Lateral Sclerosis Research
- Ion channel regulation and function
- Parkinson's Disease Mechanisms and Treatments
Inserm
2018-2024
Centre National de la Recherche Scientifique
2022-2024
University of Alberta
2020-2024
Centre de Recherche en Cancérologie de Lyon
2022-2024
Laboratoire CarMeN
2018-2023
Université Claude Bernard Lyon 1
2018-2023
Hospices Civils de Lyon
2019-2023
Institut National de Recherche en Santé Publique
2021
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2021
Institut National des Sciences Appliquées de Lyon
2019
Endoplasmic reticulum (ER) homeostasis requires molecular regulators that tailor mitochondrial bioenergetics to the needs of protein folding. For instance, calnexin maintains mitochondria metabolism and mitochondria-ER contacts (MERCs) through reactive oxygen species (ROS) from NADPH oxidase 4 (NOX4). However, induction ER stress a quick rewiring adapt new energy needs. This machinery is not characterized. We now show oxidoreductase ERO1⍺ covalently interacts with kinase RNA-like (PERK) upon...
Abstract Glioblastoma (GBM) is a deadly and the most common primary brain tumor in adults. Due to their regulation of high number mRNA transcripts, microRNAs (miRNAs) are key molecules control biological processes thereby promising therapeutic targets for GBM patients. In this regard, we recently reported miRNAs as strong modulators aggressiveness. Here, using an integrative comprehensive analysis TCGA database transcriptome biopsies, identified three critical clinically relevant GBM,...
Under physiological conditions, nitric oxide (NO) produced by the endothelial NO synthase (eNOS) upregulates hepatic insulin sensitivity. Recently, contact sites between endoplasmic reticulum and mitochondria named mitochondria-associated membranes (MAMs) emerged as a crucial hub for signaling in liver. As are targets of NO, we explored whether regulates sensitivity targeting MAMs. In Huh7 cells, primary rat hepatocytes mouse livers, enhancing concentration increased MAMs, whereas inhibiting...
Summary Thioredoxin-related transmembrane proteins (TMX) of the endoplasmic reticulum (ER) have emerged as key regulators ER membrane properties. Within lumen, TMX and other redox enzymes determine oxidative conditions, which control formation ER-mitochondria contacts (ERMCS) their function. ERMCS exhibit cytoplasmic nanodomains, derived from mitochondrial reactive oxygen species (ROS), whose mechanistic regulation is uncharacterized. Our research has identified protein TMX2, uses its unique...
This retrospective study explored a cohort of metastatic breast cancer (MBC) patients with leptomeningeal disease (LMD) who participated in molecular screening program on tissue samples (primary tumor or metastasis). Clinicopathological data were extracted for 22 MBC LMD underwent (PROFILER01 (NCT01774409) SAFIR02_Breast (NCT02299999)). Clinical outcomes reported using the Kaplan-Meier method and compared log-rank test. Genomic alterations then three databases https://www.cbioportal.org/...
Interactions between mitochondria and the endoplasmic reticulum, known as MAMs, are altered in liver obesity, which contributes to disruption of insulin signaling pathway. In addition, plasma level glycine is decreased decrease strongly correlated with severity resistance. Certain nutrients have been shown regulate MAMs; therefore, we tested whether supplementation could reduce resistance by promoting MAM integrity. Glycine (5 mM) supported integrity response primary rat hepatocytes cultured...
Aim: To evaluate the impact of a saturated fatty acid (SFA)-enriched diet (hyperlipidic, HL) in post-weaning offspring subjected to maternal protein restriction expression liver genes redox balance and inflammatory pathway.Main methods: Pregnant Wistar rats received either control (C) or low (LP, 8% protein) during gestation lactation. At weaning, pups C HL (+70% SFA) diets up 90 days life.Key findings: It was verified that circulating markers lipid metabolism function were not significantly...