A5061846814- Acoustic Wave Resonator Technologies
- Advanced MEMS and NEMS Technologies
- Mechanical and Optical Resonators
- Magnetic Properties and Applications
- Magnetic properties of thin films
- Metallic Glasses and Amorphous Alloys
- Ultrasonics and Acoustic Wave Propagation
- Ferroelectric and Piezoelectric Materials
- Advanced Fiber Optic Sensors
- Cancer Cells and Metastasis
- Estrogen and related hormone effects
- Chemical Synthesis and Reactions
- Force Microscopy Techniques and Applications
- Fatty Acid Research and Health
- Advanced Sensor and Energy Harvesting Materials
- Cancer, Hypoxia, and Metabolism
- HER2/EGFR in Cancer Research
- Copper Interconnects and Reliability
- Reproductive Biology and Fertility
- Breast Cancer Treatment Studies
- Oxidative Organic Chemistry Reactions
- Magnetic Properties of Alloys
- Inflammatory mediators and NSAID effects
- Ovarian function and disorders
- Radical Photochemical Reactions
Tohoku University
1993-2024
Tohoku University Hospital
2024
Gakushuin University
2018
Utsunomiya University
2015-2018
Tokyo University of Agriculture and Technology
2015-2018
Hokkaido Research Organization
2017
Chiba University
1997-2009
Nihon University
2008
Toho University
2005
Kitami Institute of Technology
2005
Chemokines secreted from stromal cells have important roles for interactions with carcinoma and regulating tumor progression. C-C motif chemokine ligand (CCL) 5 is expressed in various types of associated progression, interacting receptor (CCR) 1, 3 cells. However, the expression on CCL5 its receptors so far not been well-examined human breast tissues. We therefore immunolocalized CCL5, as well CCR1, 5, 111 tissues correlated them clinicopathological characteristics. Stromal immunoreactivity...
High-mobility group box 1 (HMGB1) functions as damage-associated molecular pattern (DAMPs), released into extracellular space during cellular stress. Extracellular HMGB1 act signal molecules through Toll-like receptor (TLR) 2 or TLR4, exerting diverse in both normal cells and malignant including breast cancer. However, their comprehensive examination cancer tissues is lacking. Thus, we immunolocalized them 112 tissues, correlating immunoreactivity with clinicopathological parameters clinical...
Tumor-associated macrophages (TAMs) contribute to tumor progression and chemoresistance; it is therefore important clarify the altered functions of following chemotherapy. While extracellular heat shock protein (HSP) 70 associated with therapeutic resistance, effects HSP70 on TAMs remain largely unknown. Here, we conducted in vitro experiments immunohistochemistry 116 breast carcinoma specimens determine whether secretion from cancer cells chemotherapy affects macrophage function. It was...
The paper describes how the characteristics of leaky surface acoustic wave (LSAW) propagation depend on thickness Al grating electrodes rotated Y-X LiTaO3. It is shown that loss arising from nature changes parabolically with both electrode and rotation angle becomes zero when are properly determined. This means even thick needed in device design, always realized by determining angle. When 0.07 to 0.1 wavelength for example, LSAWs 40-42 degrees LiTaO3 give without deteriorating other...
Abstract
This paper describes a large SAW velocity change obtained in delay line consisting of an amorphous TbFe <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> film on LiNbO xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> substrate. When external bias field about 4 kOe was applied parallel to the direction propagation, percentage attained -0.27 %. The value this is several times as that previously reported. may be used for trimming small...
The maturation rate of canine oocytes during in vitro (IVM) needs to be improved. present study was designed evaluate the effects insulin-like growth factor-1 (IGF-1) on IVM oocytes. Ovaries were obtained by ovariohysterectomy and sliced release cumulus-oocyte complexes (COCs). In Experiment 1, different concentrations IGF-1 nuclear investigated. COCs cultured a modified medium (mTCM199) with (0, 0.5, 5, 10, 50 µg/ml). At end 48 h culture, fixed stained their stage. Supplementation µg/ml...
Kallikrein-related peptides (KLKs) form an evolutionally conserved subgroup of secreted serine proteases that consists 15 members (KLK1-15). Previous studies have shown KLKs regulate diverse biological processes, but the clinical significance remains largely unclear in human breast cancers. We examined expression profile KLK genes carcinomas using microarray data. Next, we immunolocalized KLK12 140 and evaluated its significance. Subsequently, effects on proliferation migration cancer cell...
Prostate cancer is one of the most common malignancies in men, and there a need to explore novel biomarkers or therapeutic targets. Toll-like receptor 4 (TLR4) expressed not only antigen-presenting cells but also types human malignancies, contributing disease progression, although its clinical significance functional role prostate remains unclear. Therefore, we immunolocalized TLR4 117 tissues address clinicopathological significance. Additionally, performed vitro assays examine effects on...
The present study was conducted to evaluate whether supplementation of semen extender with glutathione (GSH) can maintain the quality frozen-thawed canine spermatozoa. Eighteen ejaculates were obtained from 5 dogs and placed in (20% egg yolk, Tris, citric acid, lactose, raffinose, antibiotics 6.5% glycerol) containing 0 (control), 2.5, 5, 7.5 or 10 mM GSH. samples cooled 4 C then frozen liquid nitrogen vapor. Motility parameters sperm evaluated at 0, 1, 2, 3, 4, 12 24 h after thawing. Sperm...
A micro actuator that is called a distributed electrostatic actuator, because it consists of many driving units, and driven by force described. Each unit has wavelike electrodes, which are insulated pull each other the force. The deformation this depends on force, elasticity structure, external motion was analyzed with finite-element method (FEM), macro model fabricated to verify its motion. It confirmed actuator's apparent compliance can be controlled feedback control system using...
An intrahepatic mass was incidentally found in a 41-year-old man with history of traffic accident injury which resulted removal ruptured spleen. Hepatic splenosis considered the differential diagnosis but magnetic resonance imaging showed hypointensity on T2-weighted images, atypical for normal Histologically, sinusoidal structures and lymphoid follicular aggregates. Immunohistochemical study that phenotype vascular lining cells CD8-positive, CD31-positive, CD34 negative, pattern diagnostic...
The study purpose was to examine the usefulness of perfusion echoplanar MR imaging with a superparamagnetic iron oxide (SHU-555A) for evaluating vascularity hepatocellular carcinomas.Twenty-two patients 32 carcinomas underwent bolus injection (0.7-1.1 ml) SHU-555A. Echoplanar sequences included multishot spin-echo (17 patients) and single-shot gradient-echo (five imaging. Image acquisition repeated every 30 sec 3 min sequence 2 100 sequence. Lesion signal intensity versus time curves were...
To determine whether adrenal adenomas can be differentiated from metastases on fat-saturated magnetic resonance (MR) images.Twenty-eight and 20 metastatic lesions were imaged at 1.5 T by means of T1- T2-weighted gadolinium-enhanced T1-weighted sequences. The authors evaluated visually structures high signal intensity (hyperintense rim sign) could observed in the outer margin masses.Twenty-six 28 revealed hyperintense sign least one kind image, compared with only metastases. sensitivity as...
This paper describes the development of a high-speed laser probe system for surface acoustic wave (SAW) devices. A fast scanning rate 2.5 kS/s is realized by continuous stage translation and successive acquisition detector output data-logger. Trigger pulses are generated from high-precision linear-scale installed in fed to data-logger synchronization with movement. The phase-sensitive, knife-edge method used optical detection. makes very unsusceptible low-frequency mechanical vibration...
This paper describes the characterization of SAW propagation in layered substrate and overlayered structures. The software based on finite element method spectral domain analysis was newly developed applied to under an infinitely-long Al interdigital transducer a rotated Y-cut LiTaO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> /sapphire substrate. Because thickness, series spurious resonances appears. It is shown that excitation...
Enteroendocrine cells (EEs) are evolutionarily conserved gastrointestinal secretory that show scattered distribution in the intestinal epithelium. These classified into several subtypes based on hormones they produce both mammals and insects. In fruit fly Drosophila, it has been suggested nearly equal numbers of two EEs (Allatostatin A: AstA Diuretic hormone 31 : Dh31) alternately produced from stem posterior midgut. However, we found these not always present this manner, but rather...
Forkhead box (FOX) proteins are family of transcriptional factors and regulate cell growth differentiation as well embryogenesis longevity. Previous studies have demonstrated that several FOX members or metastasis breast carcinoma, but clinical significance total remains unclear. We first examined associations between expression 40 genes TNM status 19 carcinoma using microarray data. Subsequently, we immunolocalized FOXI1 in 140 carcinomas evaluated its clinicopathological significance. In...
The paper describes how leaky surface acoustic wave (LSAW) propagation characteristics on LiTaO/sub 3/ depend upon its rotation angle when the Al electrode thickness is increased. It shown that loss arising from nature changes parabolically with both film and angle, becomes zero they are properly chosen. This means even relatively thick electrodes needed, always achieved by determining for LiTO/sub 3/. When 0.07/spl sim/0.1 wavelengths, example, LSAWs 40/spl sim/42/spl deg/ Y-X offer without...