A5072103005- Sarcoidosis and Beryllium Toxicity Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Helicobacter pylori-related gastroenterology studies
- Trace Elements in Health
- Eosinophilic Esophagitis
- Bacillus and Francisella bacterial research
- Occupational exposure and asthma
- Medical History and Innovations
- Orthopedic Infections and Treatments
- S100 Proteins and Annexins
- IgG4-Related and Inflammatory Diseases
- Biomarkers in Disease Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Vascular Anomalies and Treatments
- GDF15 and Related Biomarkers
- Ultrasound and Hyperthermia Applications
- Pulmonary Hypertension Research and Treatments
- Genetic factors in colorectal cancer
- Health and Medical Research Impacts
- Hepatitis C virus research
- Inhalation and Respiratory Drug Delivery
- Gastrointestinal disorders and treatments
- Gastroesophageal reflux and treatments
Siberian State Medical University
2010-2025
The lifestyle of people nowadays and poor diet are factors affecting the increasing incidence digestive diseases in all over world. search for new methods early diagnosis disease is an urgent issue modern medicine. In last decade, much attention has been paid to various biological markers that can be used assess risk development, response therapy, possible development complications. Biomarkers clinical medicine as additional tools not only improve gastrointestinal but also effectiveness...
Aim . Using statistical modeling techniques, we aim to develop a model that optimizes the prediction of severity sarcoidosis affects respiratory system (SRS) based on identification and determination signs (anamnestic, clinical, laboratory, instrumental examination data, etc.) associated with disease subsequent stratification long-term risk for pulmonary hypertension (PH) development. Materials methods The 12-year observational cohort comparative study included 298 participants, both male...
Taking into account the increase in level of cardiovascular diseases recent decades, clinician faces task attempting to make fastest possible diagnosis pathology at its earliest stages. That is why aim our work was identify main groups biological markers, and separate role each them assessment risk development, progression complications diseases. We have given working classification markers processes with allocation their types, as well basic criteria for “ideal” marker. Finally, an attempt...
to study relationship between parameters of intracardiac hemodynamics assessed by Doppler echocardiography and functional activity endothelium, hepatic blood flow severity portal hypertension in patients with cirrhosis the liver (CL) different etiology.We found that changes structural heart LC depended on stage compensation were accompanied rearrangement hemodynamics. Pulmonary arterial (PAH) was 11.1% LC. PAH moderate more frequent end-stage disease (Child-Pugh class C) compared those...
As a rule, heart damage in patients with sarcoidosis of respiratory organs (SOD) is not diagnosed time, so very important and urgent task to identify common rhythm conduction disorders. The aim the study was investigate main clinical manifestations SOD, depending on peculiarities disease course compare frequency severity pulmonary extrapulmonary sarcoidosis, including myocardial lesions electrocardiographic (ECG) signs Methods . In period 2006– 2016, pilot open prospective uncontrolled...
The objective of the study: to study radiological and morphological parallels in respiratory sarcoidosis (RS). Subjects methods . 121 patients with were enrolled study, their ages varied from 21 66 years, they all examined 2007-2019. analysis manifestations was assessed according main parameters (symmetry lesions, size intrathoracic lymph nodes, presence dissemination, pneumofibrosis). extended testing biopsy specimens carried including evaluation quantitative qualitative composition...
Sarcoidosis is a systemic disease characterized by the development of chronic immune inflammation and formation granulomas. It important to know clinical, morphological immunologic variants course this in order investigate pathomorphologic parameters granuloma. Of late negative trends have been observed changes sarcoidosis pathomorphology. Due above it predictors for disease, including specific granulematous inflammatory process various clinical not only from point view diagnostics but...
Резюме. Целью исследования было изучение показателей вентиляционной функции легких, а также структурно-функционального состояния правого отдела сердца и кровотока в легочной артерии сопоставлении с клиническим течением показателями портальной гемодинамики у больных циррозом печени (ЦП). Установлено, что изменение структурно-функциональных при ЦП зависит от стадии компенсации гипертензии сопровождается перестройкой параметров внутрисердечной гемодинамики. Выявлено, наличием артериальной имеют...
This paper presents the results obtained by investigation of morphological condition a gastric mucosa and serum concentration pepsinogen-I, pepsinogen-II, gastrin-17, as well H. pylori IgG antibodies using «Gastropanel» test system when examining patients suffering from duodenal ulcer combined with bronchial asthma. It was reveled that level is in close relation to gastritis activity Helicjbacter bacterization mucosa, thus expanding application for diagnosing not only atrophic gastritis, but...
In the literature review, modern views on features of pathogenesis and diagnosis pulmonary hypertension associated with portal sarcoidosis respiratory organs are presented. A variety is due to lack a convincing evidence base underlying algorithm for treatment this pathology. Pulmonary one most complex cardiological problems represents pathological condition that based increasing resistance blood flow in small circle circulation at any site. Unlike systemic arteries, there no direct access...
Aim . To study clinical and morphological phenotypes in different variants of the course intrathoracic sarcoidosis isolate new phenotypes. Materials methods The included 121 patients with aged 21–66 years (50.4% were men, 49.6% women, average age at time disease onset was 38 years) over period 2007– 2019. During examination, patients’ complaints studied thoroughly, diagnosis histologically verified all cases. an extended histological quantitative qualitative composition biopsy specimens...
Aim. The aim of the study was to frequency occurrence exposure harmful occupational factors in patients with sarcoidosis respiratory organs, depending on course disease. Materials and methods. An open prospective included 121 system from age 21 66 years, 20072019. diagnosis histologically confirmed all patients. Patients underwent a set laboratory instrumental examinations, studied profane history. presence history contact dangerous production clarified. To determine effect factor...
The history of a scientific medical society physicians in Russia and Tomsk. Describe the contribution outstanding scientists clinicians development practitioners, as well large schools known not only but also abroad. Outlines achievements last decade.
The objective of this study was to investigate the relationship between polymorphisms PACRG gene (rs10945890) and CD80 (rs1880661) with susceptibility, course, outcome sarcoidosis. involved 142 sarcoidosis patients 150 healthy individuals from Siberian region Russia. Over 200 clinical features were analyzed at disease onset, followed up for least seven years. PCR-RFLP utilized genotyping, statistical analysis performed using X2 test, Fisher's exact logistic regression after adjusting age sex...
The aim of this work was to study changes in mechanical lung properties cases COPD general and different zones depending on the body position. Materials methods . research performed 37 patients with chronic obstructive pulmonary disease (COPD) vertical horizontal positions (VP HP). Results analysis integral respiration mechanics has revealed a reduction dynamic compliance an increase total non-elastic resistance during expiration (TNRexp) HP vs. VP. At same time, despite TNRexp HP, breathing...
Sarcoidosis may show a different course from spontaneous regression to chronic recurrent forms. The search for prognosis criteria remains relevant the disease. aim was study relationship between granuloma morphology and clinical of sarcoidosis. Materials: A morphological lungs obtained during VATS biopsies performed in 121 patients with sarcoidosis onset. It included formula cellular elements, number granulomas, giant multinucleated cells, presence hyalinosis, necrosis, calcification,...