A5049126620- Sarcoidosis and Beryllium Toxicity Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Helicobacter pylori-related gastroenterology studies
- Eosinophilic Esophagitis
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Gastroesophageal reflux and treatments
- Health, psychology, and well-being
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Chronic Obstructive Pulmonary Disease (COPD) Research
- IL-33, ST2, and ILC Pathways
- Respiratory and Cough-Related Research
- Eating Disorders and Behaviors
- Radioactivity and Radon Measurements
- Vascular Anomalies and Treatments
- High Altitude and Hypoxia
- Medical and Biological Sciences
- Research on Leishmaniasis Studies
- Pediatric Pain Management Techniques
- Asthma and respiratory diseases
- Occupational exposure and asthma
- Tracheal and airway disorders
- COVID-19 and healthcare impacts
- Atrial Fibrillation Management and Outcomes
- Central Venous Catheters and Hemodialysis
Siberian State Medical University
2003-2024
Ministry of Health of the Russian Federation
2024
Institute of Molecular Pathology and Pathomorphology
2004
Academy of Medical Sciences
2004
Semmelweis University
1988
Aim . Using statistical modeling techniques, we aim to develop a model that optimizes the prediction of severity sarcoidosis affects respiratory system (SRS) based on identification and determination signs (anamnestic, clinical, laboratory, instrumental examination data, etc.) associated with disease subsequent stratification long-term risk for pulmonary hypertension (PH) development. Materials methods The 12-year observational cohort comparative study included 298 participants, both male...
to study relationship between parameters of intracardiac hemodynamics assessed by Doppler echocardiography and functional activity endothelium, hepatic blood flow severity portal hypertension in patients with cirrhosis the liver (CL) different etiology.We found that changes structural heart LC depended on stage compensation were accompanied rearrangement hemodynamics. Pulmonary arterial (PAH) was 11.1% LC. PAH moderate more frequent end-stage disease (Child-Pugh class C) compared those...
The article presents data concerning prevalence of sarmidosis in Tomsk and the region for 16 years impacting ecological geochemical factors (elemental composite incrustation snow, soils) on disease. morbidity individuals without undergoing impact occupational hazards is reliably higher areas with increased anthropogenic loading (the Oktiabrskii district Tomsk, rural district, North- Eastern sector, city Seversk, Parabelskii Kolpashevskii districts, Strejevoii). positive associations were...
As a rule, heart damage in patients with sarcoidosis of respiratory organs (SOD) is not diagnosed time, so very important and urgent task to identify common rhythm conduction disorders. The aim the study was investigate main clinical manifestations SOD, depending on peculiarities disease course compare frequency severity pulmonary extrapulmonary sarcoidosis, including myocardial lesions electrocardiographic (ECG) signs Methods . In period 2006– 2016, pilot open prospective uncontrolled...
Cystic fibrosis is one of the urgent medical and social problems health care systems in most countries due to fairly high prevalence, development multi-organ lesions, poor outcomes. Due modern advances diagnosis treatment cystic fibrosis, not only has average life expectancy patients increased, but their quality also improved, it become possible maintain pregnancy childbearing. Since can adversely affect course pregnancy, childbirth, both mother child, proper management women with during...
Relevance. Among the studies during COVID-19 pandemic, a special role is played by examining prognostic value of clinical, laboratory and instrumental markers in patients. Biomarkers with absolute sensitivity specificity for predicting outcome new coronavirus infection have not been identified yet. Aim: To identify early clinical predictors severity mortality hospitalized patients to evaluate effectiveness pharmacotherapy outpatient hospital settings. Methodology research methods. A...
The lecture considers the results of research conducted by Russian and foreign scientists concerning characteristics all types metabolic disorders hormonal imbalance in undifferentiated connective tissue dysplasia (CTD). Understanding role development course diseases associated with CTD is great importance for pathogenetically grounded algorithms diagnosis, treatment, prevention emergency conditions.
The objective of the study: to study radiological and morphological parallels in respiratory sarcoidosis (RS). Subjects methods . 121 patients with were enrolled study, their ages varied from 21 66 years, they all examined 2007-2019. analysis manifestations was assessed according main parameters (symmetry lesions, size intrathoracic lymph nodes, presence dissemination, pneumofibrosis). extended testing biopsy specimens carried including evaluation quantitative qualitative composition...
Sarcoidosis is a systemic disease characterized by the development of chronic immune inflammation and formation granulomas. It important to know clinical, morphological immunologic variants course this in order investigate pathomorphologic parameters granuloma. Of late negative trends have been observed changes sarcoidosis pathomorphology. Due above it predictors for disease, including specific granulematous inflammatory process various clinical not only from point view diagnostics but...
This study was aimed at measuring concentrations and investigation of relationships between macro- microelements in mediastinal lymph nodes patients with sarcoidosis. Methods. The involved 28 (50% were males; median age, 42.5 (23; 53) years) confirmed diagnosis Autopsy samples from 13 individuals died occasional causes (41.2% 43 (38.7; 61.3) used for comparison. groups did not differ age gender. Neutron activation analysis to investigate chemical elements node tissue samples. Results....
Here we present a clinical case of cardiac sarcoidosis. The article discusses the difficulties differential diagnosis in patients emergently hospitalized cardiology department with recurrent chest pain, no changes electrocardiogram (ECG), and presumptive acute coronary syndrome without ST segment elevation (NSTE-ACS). A careful history taking, invasive angiography, contrast-enhanced (gadolinium-based contrast media) magnetic resonance imaging (CMR) contributed to correct diagnostic decision...
Резюме. Целью исследования было изучение показателей вентиляционной функции легких, а также структурно-функционального состояния правого отдела сердца и кровотока в легочной артерии сопоставлении с клиническим течением показателями портальной гемодинамики у больных циррозом печени (ЦП). Установлено, что изменение структурно-функциональных при ЦП зависит от стадии компенсации гипертензии сопровождается перестройкой параметров внутрисердечной гемодинамики. Выявлено, наличием артериальной имеют...
This paper presents the results obtained by investigation of morphological condition a gastric mucosa and serum concentration pepsinogen-I, pepsinogen-II, gastrin-17, as well H. pylori IgG antibodies using «Gastropanel» test system when examining patients suffering from duodenal ulcer combined with bronchial asthma. It was reveled that level is in close relation to gastritis activity Helicjbacter bacterization mucosa, thus expanding application for diagnosing not only atrophic gastritis, but...
The aim of the study was to ventilation function lungs and echocardiography activities right left ventricular, blood flow disorders in pulmonary artery confront with clinical pictures portal haemodynamics patients a liver cirrhosis. Established, that change structural-functional parts heart cirrhosis depend on great extent, weight disease be accompanied raorganisation central forming arterial hypertension. Pulmonary hypertension close association circulation represented not rare complication
Aim . To study clinical and morphological phenotypes in different variants of the course intrathoracic sarcoidosis isolate new phenotypes. Materials methods The included 121 patients with aged 21–66 years (50.4% were men, 49.6% women, average age at time disease onset was 38 years) over period 2007– 2019. During examination, patients’ complaints studied thoroughly, diagnosis histologically verified all cases. an extended histological quantitative qualitative composition biopsy specimens...
Aimed at investigating pathomorphological aspects of mutual influence bronchial asthma and gastroesophageal reflux (GER), gastrobioptates, bronchobioptates mucus 48 patients having GER 55 not it. Helicobacter inflammation fundal stomach department mucous membrane atrophy (non-severe asthma) using systemic corticosteroids (severe were shown to on forming. GER-positive revealed hyperproduction dense mucus.
Aim. The aim of the study was to frequency occurrence exposure harmful occupational factors in patients with sarcoidosis respiratory organs, depending on course disease. Materials and methods. An open prospective included 121 system from age 21 66 years, 20072019. diagnosis histologically confirmed all patients. Patients underwent a set laboratory instrumental examinations, studied profane history. presence history contact dangerous production clarified. To determine effect factor...
The objective of this study was to investigate the relationship between polymorphisms PACRG gene (rs10945890) and CD80 (rs1880661) with susceptibility, course, outcome sarcoidosis. involved 142 sarcoidosis patients 150 healthy individuals from Siberian region Russia. Over 200 clinical features were analyzed at disease onset, followed up for least seven years. PCR-RFLP utilized genotyping, statistical analysis performed using X2 test, Fisher's exact logistic regression after adjusting age sex...
The aim of the study was to investigate peculiarities anxiety-depressive disorders (ADD) course in patients with bronchial asthma (BA) combined erosive-ulcerative lesions (EUL) gastro-duodenal area (GDA) and their interaction evaluate treatment efficacy this category taking into consideration psycho-pathological disorders. Combination BA EUL GDA established enhance psychological tension degree increase ADD which requires pharmacological cor-rection.