A5048069982- Liver Disease Diagnosis and Treatment
- Sarcoidosis and Beryllium Toxicity Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Hepatitis C virus research
- Eosinophilic Disorders and Syndromes
- Drug-Induced Hepatotoxicity and Protection
- Galectins and Cancer Biology
- Liver Diseases and Immunity
- Helicobacter pylori-related gastroenterology studies
- Sphingolipid Metabolism and Signaling
- Eosinophilic Esophagitis
- Occupational exposure and asthma
- Trace Elements in Health
- Bacillus and Francisella bacterial research
- Cytokine Signaling Pathways and Interactions
- Cancer, Lipids, and Metabolism
- Toxin Mechanisms and Immunotoxins
- Prostate Cancer Treatment and Research
- Metastasis and carcinoma case studies
- Systemic Lupus Erythematosus Research
- Nanoparticle-Based Drug Delivery
- Lung Cancer Research Studies
- Sinusitis and nasal conditions
- IgG4-Related and Inflammatory Diseases
- Glycosylation and Glycoproteins Research
Siberian State Medical University
2017-2025
Ulyanovsk Regional Oncology Center
2017-2021
Ministry of Health of the Russian Federation
2018
The lifestyle of people nowadays and poor diet are factors affecting the increasing incidence digestive diseases in all over world. search for new methods early diagnosis disease is an urgent issue modern medicine. In last decade, much attention has been paid to various biological markers that can be used assess risk development, response therapy, possible development complications. Biomarkers clinical medicine as additional tools not only improve gastrointestinal but also effectiveness...
Aim . Using statistical modeling techniques, we aim to develop a model that optimizes the prediction of severity sarcoidosis affects respiratory system (SRS) based on identification and determination signs (anamnestic, clinical, laboratory, instrumental examination data, etc.) associated with disease subsequent stratification long-term risk for pulmonary hypertension (PH) development. Materials methods The 12-year observational cohort comparative study included 298 participants, both male...
The objective of the study: to study radiological and morphological parallels in respiratory sarcoidosis (RS). Subjects methods . 121 patients with were enrolled study, their ages varied from 21 66 years, they all examined 2007-2019. analysis manifestations was assessed according main parameters (symmetry lesions, size intrathoracic lymph nodes, presence dissemination, pneumofibrosis). extended testing biopsy specimens carried including evaluation quantitative qualitative composition...
Sarcoidosis is a systemic disease characterized by the development of chronic immune inflammation and formation granulomas. It important to know clinical, morphological immunologic variants course this in order investigate pathomorphologic parameters granuloma. Of late negative trends have been observed changes sarcoidosis pathomorphology. Due above it predictors for disease, including specific granulematous inflammatory process various clinical not only from point view diagnostics but...
The purpose of the study was to analyze expression proteins-regulators cell cycle (p53 and p21) receptors for endothelial (VEGFR) epidermal (EGFR) growth factors depending on galectin-1 in tumor cells gastric cancer. Materials methods. 52 patients with diagnosis cancer were examined. We used tissue samples malignant neoplasms stomach, which obtained during surgical intervention. In galectin-1, p53 p21 proteins, VEGF EGF evaluated by immunohistochemistry. results analyzed statistical Results....
Background. Serous cystic pancreatic neoplasm is a rare tumor, accounting for 1–2 % of all tumors. In 2010, mixed serous neuroendocrine neoplasia was included into the classification WHO Only few cases this disease have been reported in literature. Mixed often associated with von Hippel Lindau disease. Most authors recommend surgery as main treatment Case report. We present case not The patient underwent spleen – preserving distal pancreas resection. diagnosis histologically and...
Aim . To study clinical and morphological phenotypes in different variants of the course intrathoracic sarcoidosis isolate new phenotypes. Materials methods The included 121 patients with aged 21–66 years (50.4% were men, 49.6% women, average age at time disease onset was 38 years) over period 2007– 2019. During examination, patients’ complaints studied thoroughly, diagnosis histologically verified all cases. an extended histological quantitative qualitative composition biopsy specimens...
Aim. The aim of the study was to frequency occurrence exposure harmful occupational factors in patients with sarcoidosis respiratory organs, depending on course disease. Materials and methods. An open prospective included 121 system from age 21 66 years, 20072019. diagnosis histologically confirmed all patients. Patients underwent a set laboratory instrumental examinations, studied profane history. presence history contact dangerous production clarified. To determine effect factor...
To ascertain the severity of opium-induced liver injury for chronic viral hepatitis C (HCV) patients with detection morphological characters hepatocyte impact by opiates. Needle biopsy and light microscopy material were made both isolated HCV HCV+opiomania patients. Liver (hepatitis activity, fibrosis stage) against background opiomania does not differ from case HCV. Use alcohol opium addicts even in very small doses (10—15 g per day) cause development significantly more severe injury....
A comparison of degrees necroinflammatory activity and fibrosis stages in 433 biopsy specimens patients with chronic viral hepatitis C (monoinfection combination drug abuse, alcoholic disease, opisthorchosis). Found that ethyl alcohol is the greatest character weights alteration severity multiple sclerosis HCV-infection. Drug abuse enhances liver, but no histological activity, only mono-HCV infection. Opisthorchosis defines weakly expressed sclerotic changes (by)
Aim. To study molecular genetic and morphological features of neoplasms in stomach colon cancer associated with tissue eosinophilia. 
 Methods. Study material was the samples malignant obtained from surgical procedures. groups were identified depending on presence or absence eosinophilic infiltration tumour as well neoplasm localization. Medical records outpatient patient cards analyzed, matastases regional lymph nodes grade differentiation cells evaluated. In expression p53 p21...
Clinical manifestations of sarcoidosis are varied. The reasons have not been completely understood. purpose the study is to explore relationship between morphology granulomas and clinical picture sarcoidosis. <b>Materials:</b> Specimens lungs (n=59) mediastinal lymph nodes (n=15) were obtained during VATS biopsies from patients (radiological stage 1, n=19; 2, n=53 patients; 3, n=2). Morphological included determination formula cellular elements, presence hyalinosis, necrosis, calcification,...
Опухолеассоциированная тканевая эозинофилия определяется как эозинофильная инфильтрация стромы опухоли. Эта реакция, полагают, играет важную роль в канцерогенезе. Считается, что эозинофилы обладают противоопухолевой активностью за счет высвобождения цитотоксических белков. Цель исследования - изучение молекулярно-генетических механизмов формирования опухолеассоциированной тканевой эозинофилии у больных раком желудка и толстой кишки. Методика. Материалом служили образцы опухолевой ткани...
Background. Currently, in the study of prostate cancer, much attention is given to specific molecular patterns reflecting biological potential tumor. Of most interest analysis proteins chimeric genes a tumor.
 Aim peculiarities ERG and PBOV1 expression tumor cells correlation them with prognostic parameters disease patients.
 Materials Methods. The group consisted 85 patients diagnosed prostatic carcinoma (stage II-III disease, T1-3N1-2M0), after radical prostatectomy. No...