<b><i>Introduction:</i></b> Cognitive-behavioral therapy (CBT) for obsessive-compulsive disorder (OCD) has proven its efficacy in randomized controlled trials (RCTs). <b><i>Objective:</i></b> To test generalizability to routine care settings, we conducted an effectiveness study provide naturalistic outcome data and their predictors. <b><i>Methods:</i></b> Pre-post changes symptoms impairment as well response rates were...

Exposure and response prevention is effective recommended as the first choice for treating obsessive-compulsive disorders (OCD). Its mechanisms of action are rarely studied, but two major theories make distinct assumptions: while emotional processing theory assumes that treatment effects associated with habituation within between exposure sessions, inhibitory learning approach highlights acquisition additional associations, implying alternative like expectancy violation. The present study...

Objectives: Machine learning models predicting treatment outcomes for individual patients may yield high clinical utility. However, few studies tested the utility of easy to acquire and low-cost sociodemographic data. In previous work, we reported significant predictions still insufficient immediate use in a sample with broad diagnostic spectrum. We here examined whether will improve diagnostically more homogeneous yet large naturalistic obsessive-compulsive disorder (OCD) sample. Methods:...

Altered heart rate (HR) and variability (HRV) are common observations in psychiatric disorders. Yet, few studies have examined these cardiac measures obsessive-compulsive disorder (OCD). The current study aimed to investigate HR HRV, indexed by the root mean square of successive differences (RMSSD) further time domain indices, as putative biological characteristics OCD. Electrocardiogram was recorded during a five-minute resting state. Group between patients with OCD (n = 96), healthy...

Cognitive behavioral therapy (CBT) is an effective treatment for obsessive-compulsive disorder (OCD) and may afford stable long-term improvements. It not clear, however, how stability or symptom recurrence can be predicted at the time of termination CBT.In a 1-year follow-up intention-to-treat study with 120 OCD patients receiving individual CBT university outpatient unit, we investigated predictive value international consensus criteria response only (Y-BOCS score reduction by least 35%)...

Overactive performance monitoring, as reflected by enhanced neural responses to errors (the error-related negativity, ERN), is considered a biomarker for obsessive-compulsive disorder (OCD) and may be promising target novel treatment approaches. Prior research suggests that non-invasive brain stimulation with transcranial direct current (tDCS) reduce the ERN in healthy individuals, yet no study has investigated its efficacy attenuating OCD. In this preregistered, randomized, sham-controlled,...

Abstract Obsessive-compulsive disorder (OCD) is a prevalent mental affecting ~2–3% of the population. This involves genetic and, possibly, epigenetic risk factors. The dynamic nature epigenetics also presents promising avenue for identifying biomarkers associated with symptom severity, clinical progression, and treatment response in OCD. We, therefore, conducted comprehensive case-control investigation using Illumina MethylationEPIC BeadChip, encompassing 185 OCD patients 199 controls...

Although cognitive behavioral therapy is a highly effective treatment for obsessive-compulsive disorder (OCD), yielding large symptom reductions on the group level, individual response varies considerably. Identification of predictors may provide important information maximizing and thus achieving efficient resource allocation. Here, we investigated predictive value previously identified biomarkers OCD, namely error-related activity supplementary motor area (SMA) sensorimotor network (SMN,...

Abstract Pavlovian learning mechanisms are of great importance both for models psychiatric disorders and treatment approaches, but understudied in obsessive‐compulsive disorder (OCD). Using an established fear conditioning reversal procedure, we studied skin conductance responses 41 patients with OCD 32 matched healthy control participants. Within groups, acquisition effects were evident. When comparing showed impaired differential threatening safe stimuli, consistent previous research. In...

Abstract Clinical and theoretical models suggest deficient volitional initiation of action in schizophrenia patients. Recent research provided an experimental model testing this assumption using saccade tasks. However, inconsistent findings necessitate a specification conditions on which the deficit may occur. The present study sought to detect mechanisms that contribute poor performance. Sixteen patients 16 healthy control participants performed visually guided two types All tasks varied as...

Abstract: The clinician-rated Yale-Brown Obsessive Compulsive Scale (Y-BOCS) is a widely used assessment tool for obsessive-compulsive disorder (OCD). However, the measurement invariance (MI) properties of Y-BOCS, prerequisite group or time point comparisons in clinical research, have received little attention previous studies. In this study, we aim to comprehensively investigate factor structure and MI Y-BOCS severity rating its symptom checklist, utilizing large sample OCD patients ( N =...

Abstract Pavlovian learning mechanisms are of great importance both for models psychiatric disorders and treatment approaches, but understudied in obsessive-compulsive disorder (OCD). Using an established fear conditioning reversal procedure, we studied skin conductance responses (SCRs) 41 patients with OCD 32 matched healthy control participants. Within groups, acquisition effects were evident. When comparing showed impaired differential threatening safe stimuli, consistent previous...

Abstract Obsessive-compulsive disorder (OCD) is a mental affecting 2-3% of the general population. The dynamic nature epigenetics provides unique opportunity to find biomarkers OCD symptoms, clinical progression, and treatment response. Consequently, we analyzed case-control study on Illumina Methylation EPIC BeadChip from 185 patients 199 controls. Patients controls were assessed by trained therapists using Structured Clinical Interview for DSM-IV. We identified 12 CpGs capable classifying...

The clinician-rated Yale-Brown Obsessive Compulsive Scale (Y-BOCS) is a cornerstone in the assessment of obsessive-compulsive disorder (OCD). Measurement invariance (MI) properties Y-BOCS have very rarely been addressed past, although MI prerequisite to all group or time point comparisons clinical research. Here, we provide thorough investigation factor structure and severity rating its symptom check list large sample OCD patients ($N = 1066$). covariates interest included (before after...