A5035833238- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- Pharmaceutical Economics and Policy
- Antibiotic Use and Resistance
- Biosimilars and Bioanalytical Methods
- Health Systems, Economic Evaluations, Quality of Life
- Pharmaceutical Practices and Patient Outcomes
- Pharmaceutical studies and practices
- HIV Research and Treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV-related health complications and treatments
- Tuberculosis Research and Epidemiology
- COVID-19 Clinical Research Studies
- Medication Adherence and Compliance
- Pneumonia and Respiratory Infections
- Innovations in Medical Education
- Antibiotic Resistance in Bacteria
- Diverse Scientific Research Studies
- Healthcare Systems and Technology
- Natural Antidiabetic Agents Studies
- Urinary Tract Infections Management
- Global Maternal and Child Health
- Hepatitis C virus research
- Health Literacy and Information Accessibility
- Liver Disease Diagnosis and Treatment
University of Namibia
2015-2023
Karolinska University Hospital
2018
Karolinska Institutet
2018
University of Strathclyde
2018
University of Liverpool
2018
Ministry of Health and Social Services
2011
Makerere University
2008-2010
Infectious Diseases Institute
2008-2010
Namibia has the highest burden and incidence of hypertension in sub-Sahara Africa. Though non-adherence to antihypertensive therapy is an important cardiovascular risk factor, little known about potential ways improve adherence following universal access. The objective this study validate Hill-Bone compliance scale determine level predictors treatment primary health care settings sub-urban townships Windhoek, Namibia. Reliability was determined by Cronbach's alpha. Principal component...
Introduction There are positive aspects regarding the prescribing of fixed dose combinations (FDCs) versus medicines separately. However, these have to be balanced against concerns including increased costs and their irrationality in some cases. Consequently, there is a need review value among lower- middle-income countries (LMICs) which greatest prevalence both infectious noninfectious diseases issues affordability.Areas covered Review potential advantages, disadvantages,...
Sub-optimal antibiotic prescribing remains a public health concern in Namibia. The objective was to determine the level and predictors of compliance guidelines antibiotics acute infections at national referral hospital Namibia improve future prescribing.An analytical cross-sectional survey design. clinical records patients receiving care were reviewed. Prescribing practices assessed using self- administered questionnaire with reference Standard Treatment Guidelines (NSTG).The majority...
Background: Multiple measures introduced early to restrict COVID-19 have dramatically impacted the teaching of medical and pharmacy students, exacerbated by lack infrastructure experience with e-learning at start pandemic. In addition, costs reliability Internet across Africa pose challenges alongside undertaking clinical practical programmes. Consequently, there is a need understand many how these were addressed, given increasingly complex patients, provide future direction. Method: An...
Currently about 19 million people in Africa are known to be living with diabetes, mainly Type 2 diabetes (T2DM) (95%), estimated grow 47 by 2045. However, there concerns early diagnosis of patients 1 (T1DM) as often present late complications. There also challenges access and affordability insulin, monitoring equipment test strips typically high patient co-payments, which can catastrophic for families. These negatively impact on the quality care T1DM increasing morbidity mortality. issues...
Bacterial meningitis is a medical emergency associated with high mortality rates. Cerebrospinal fluid (CSF) culture the “gold standard” for diagnosis of and it important to establish susceptibility causative microorganism rationalize treatment. The Namibia Standard Treatment Guidelines (STGs) recommends initiation empirical antibiotic treatment in patients signs symptoms after taking CSF sample sensitivity. objective this study was assess antimicrobial sensitivity patterns microorganisms...
Abstract Background The emergence of antimicrobial resistance (AMR) among bacterial pathogens demands a local understanding the epidemiological situation. This information is needed both for clinical treatment decision-making purposes as well revision current care guidelines. Clinical AMR data from Namibia sparse, whilst urinary tract infections remain not only widespread but they disproportionally affect females. paper aims to describe national situation major uropathogens in females within...
Despite Namibia's robust medicine use systems and policies, antibiotic indicators remain suboptimal. Recent surveys rank cotrimoxazole, amoxicillin azithromycin (CAA) among the most used medicines. However, there is rising resistance to CAA (55.9%-96.7%). Unfortunately, date, have been limited studies evaluating policies improve in Namibia.To evaluate public sector pharmaceutical guidelines influencing therapeutic of antibiotics Namibia.Evaluate for through quantitative text analysis. The...
Rifampicin lowers nevirapine plasma concentrations by inducing cytochrome P450. However, few data are available on this interaction during the lead-in period of treatment. Eighteen HIV-1/tuberculosis co-infected adults receiving rifampicin daily as part anti-tuberculosis therapy were evenly randomized to initiation dose escalation (NVP200) or at 200 mg twice (NVP400). Subjects underwent 12 h intensive pharmacokinetic sampling Days 7, 14 and 21 A minimum effective concentration (MEC) 3000...
The first Medicines Utilization Research in Africa group workshop and symposium brought researchers together from across to improve their knowledge on drug utilization methodologies as well exchange ideas. As a result, progress was made research formulating future strategies enhance the rational use of medicines Africa. Anti-infectives were principal theme for 1-day following workshops. This included presentations inappropriate antibiotics ways address this. Concerns with adverse reactions...
• All antiretroviral therapies (ARTs) are potentially toxic to the liver. The rising incidence of ART induced adverse events has led guideline revision.• revision. Limited studies date evaluating liver injury in these countries. This need be addressed guide future clinical practice.• Majority patients developed significant ALT elevation within 3 months initiation. No difference between mean levels at baseline and month 6.• Patients with high risk hepatocellular damage, female sex, > grade 2...
Tenofovir disoproxil fumarate (TDF) and lopinavir/ritonavir (LPV/r) can cause renal impairment with this combination co-administered during second-line antiretroviral therapy (cART) potentially associated greater risk of nephrotoxicity. As a result, the aim study is to assess effects cART on function.Retrospective longitudinal in patients receiving cART.71 received TDF, zidovudine or stavudine, each combined 3TC/NVP 3TC/EFV. Before cART, 46.5% had abnormal kidney function. First-line no...
The second Medicines Utilization Research in Africa (MURIA) group workshop and symposium again brought researchers together from across to improve their knowledge of drug utilization (DU) methodologies exchange ideas further progress DU research Africa. This built on extensive activities the first conference including workshops multiple publications. Anti-infectives were principal theme for 2016 following workshops. included presentations regarding strategies antibiotic among African...
Generic competition and drug prices in the Malaysian off-patent pharmaceutical marketOmotayo Fatokun, Mohamed Izham Ibrahim, Azmi Hassali
Anti-inflammatory activity of medicinal plants native to Bangladesh: A reviewApurba Sarker Apu, Shakhawat Hossan Bhuyan, Shamina Saiyara Prova, Md. Abdul Muhit
BackgroundWe aimed to compare the steady-state pharmacokinetic parameters and tolerability of Triomune 40® (stavudine 40 mg, lamivudine 150 mg nevirapine 200 mg) branded formulations these drugs in HIV-infected Ugandans.
In 2009, the Ministry of Health and Social Services in Namibia decided to conduct a confirmatory assessment risk anemia associated with zidovudine (AZT)-based highly active antiretroviral therapy (HAART) using records contained three electronic databases. These did not share unique identifying number. The first step was apply probabilistic record linkage methods link databases.Records persons, aged 19-65 years, newly initiated on HAART between January 2007 June 2008, were selected from...
Background. Diabetes mellitus rates and associated costs continue to rise across Europe enhancing health authority focus on its management. The risk of complications is enhanced by poor glycaemic control, with long-acting insulin analogues developed reduce hypoglycaemia improve patient convenience. There are concerns though their considerably higher costs, but moderated reductions in costs. Biosimilars can help further However, date, price for biosimilar glargine appear limited. In addition,...