We examined the content of YouTube(™) videos on mouth (oral) cancer and evaluated their usefulness in promoting early detection oral cancer.A systematic search for containing information was conducted using keywords 'mouth cancer' 'oral cancer'. Demographics videos, including type, source, length, viewers' interaction, were evaluated, three researchers independently assessed total 188 (152 patient-oriented educational 36 testimonial videos) analyzed. The overall score ranged from 0 to 10...

Osteoimmunology peeks into the interaction of bone and immune system, which has largely proved to be a multiplex reaction. Osteocytes have been shown regulate resorption through expression RANKL in physiologic pathologic conditions. TNF-α, product is an important cytokine regulating inflammatory conditions either directly or by increasing M-CSF expressions osteoblasts stromal cells. The effect TNF-α on wide range cell types documented; however, direct osteocytes not established yet. In this...

Interleukin (IL)-33 is a member of the IL-1 family, which acts as an alarmin. Several studies suggested that IL-33 inhibited osteoclastogenesis and bone resorption. Tumor necrosis factor-α (TNF-α) considered direct inducer osteoclastogenesis. However, there has been no report regarding effect on TNF-α-induced The objective this study to investigate role In in vitro analysis osteoclastogenesis, osteoclast precursors, were derived from marrow cells, treated with or without presence TNF-α....

Tumor necrosis factor-alpha (TNF-α) is a significant cytokine that regulates bone resorption under inflammatory conditions. However, its mechanism of action in osteocytes remains unclear. In this study, highly purified were isolated from dentin matrix protein 1 (DMP1)-Topaz mice using cell sorter. RNA sequencing (RNA-seq) revealed TNF-α stimulation increased C-X-C motif chemokine ligand 10 (CXCL10) gene expression osteocytes. Although CXCL10 did not affect osteoclast differentiation vitro,...

Background/Objective: Osteocytes are the most abundant cell type in skeleton, with key endocrine functions, particularly regulating osteoblast and osteoclast activity to maintain bone quality. Angiotensin II (Ang II), a critical component of renin–angiotensin–aldosterone system, is well-known for its role vasoconstriction during hypertension. Beyond cardiovascular Ang participates various biological processes, including metabolism. While influence on proliferation, differentiation,...

Docosahexaenoic acid (DHA) is an n-3 fatty that important structural component of the cell membrane. DHA exerts potent anti-inflammatory effects through G protein-coupled receptor 120 (GPR120), which a functional for acids. also regulates osteoclast formation and function. However, no studies have investigated effect on inflammation-induced in vivo. In present study, we whether influences formation, bone resorption expression osteoclast-associated cytokines during lipopolysaccharide...

Osteocytes are abundant cells in bone, which contribute to bone maintenance. express receptor activator of nuclear factor kappa-B ligand (RANKL) and regulate osteoclast formation. Orthodontic tooth movement (OTM) occurs by resorption alveolar bone. Osteocyte-derived RANKL is critical during OTM. Additionally, tumor necrosis factor- α (TNF- ) important osteoclastogenesis Sclerostin has been reported enhance expression the MLO-Y4 osteocyte-like cell line. This study investigated effect TNF- on...

Docosahexaenoic acid (DHA) is an omega-3 fatty that has a range of positive impacts on human health, including anti-inflammatory effects and inhibition osteoclast formation via G-protein-coupled receptor 120 (GPR120). Orthodontic force was reported to induce tumor necrosis factor-α (TNF-α) expression, which activates differentiation during orthodontic tooth movement (OTM). The aim this study investigate the influence DHA TNF-α-induced OTM in vivo. We examined bone resorption within calvaria...

Dipeptidyl peptidase 4 (DPP-4) inhibition is a new therapeutic strategy for type 2 diabetic patients. DPP-4 has been reported to enhance inflammation. However, the effect of on inflammation remains unknown. Lipopolysaccharide (LPS) strong inducer and osteoclast formation. In this study, we investigated in vivo effects LPS-induced formation bone resorption, as well vitro RANKL-induced osteoclastogenesis TNF-α-induced osteoclastogenesis.LPS with or without inhibitor was subcutaneously injected...

Compressive force during orthodontic tooth movement induces osteoclast formation in vivo. TNF-α plays an important role mouse and bone resorption induced by compressive movement. Stromal cells, macrophages T cells take part TNF-α-induced vitro. Root caused odontoclasts is a major clinical problem In this study, we determined the cell type targeted compressive-force-induced odontoclast to elucidate mechanism of root An model was prepared with nickel-titanium closed coil spring inserted...

Osteoporosis morphology is characterized by bone resorption and decreases in micro-architecture parameters. Anti-osteoporosis therapy targets osteoclasts because a unique function of osteoclasts. Anti-c-fms antibodies against the receptor for macrophage colony-stimulating factor (M-CSF) inhibit osteoclast formation vitro vivo. However, effect anti-c-fms on ovariectomized (OVX) mice unknown. In this study, we evaluated osteoblast–osteoclast precursor co-culture OVX mice. Osteoblast...

Hypertension is a chronic-low grade inflammatory disease, which known to be associated with increased bone loss. Excessive activity of the local renin-angiotensin system (RAS) in leads resorption. As cytokines may activate RAS components, we hypothesized that elevated proinflammatory cytokine levels hypertension and thus lead To investigate whether salt-sensitive (SSHTN) induces osteoclastogenesis resorption, generated model SSHTN C57BL/6J mice by post-Nω-nitro-l-arginine methyl ester...

Orthodontic relapse after orthodontic treatment is a major clinical issue in the dental field. However, biological mechanism of still unclear. This study aimed to establish mouse model retention examine how affects rate and amount relapse. We also sought role osteoclastogenesis using an antibody block activity M-CSF, essential factor osteoclast formation. Mice were treated with nickel-titanium closed-coil spring that was fixed between upper incisors upper-left first molar move mesial...

The C‑X‑C receptor (CXCR) 7 agonist, VUF11207, is a chemical compound that binds specifically to CXCR7, and negatively regulates motif chemokine ligand 12 (CXCL12) CXCR4‑induced cellular events. Lipopolysaccharide (LPS) can induce inflammatory cytokines pathological bone loss. LPS also induces expression of CXCL12, enhancing sensitivity activator NF‑κB (RANKL) tumor necrosis factor‑α (TNF‑α) in vivo. RANKL TNF‑α the differentiation osteoclasts into osteoclast precursors resorption. current...

Micro-osteoperforations (MOPs) have been reported to accelerate orthodontic tooth movement (OTM), and tumor necrosis factor (TNF)-α has play a crucial role in OTM. In this report, the influence of MOPs during OTM was analyzed. We evaluated expression TNF-α with without by RT-PCR analysis. A Ni-Ti closed coil spring fixed between maxillary left first molar incisors as an mouse model move mesial direction. were prepared on lingual side upper molars. Furthermore, investigate target cell for...

Abstract Renin–angiotensin–aldosterone system plays a crucial role in the regulation of blood pressure and fluid homeostasis. It is reported to be involved mediating osteoclastogenesis bone loss diseases inflammatory resorption such as osteoporosis. Angiotensin-(1–7), product Angiotensin I II (Ang I, II), cleaved by Angiotensin-converting enzyme 2 then binds Mas receptor counteract effects produced Ang II. However, mechanism which Ang-(1–7) reduces remains unclear. Therefore, we aim...

Orthodontic tooth movement (OTM) is facilitated by two events; bone resorption on the compression side and formation tension simultaneously termed remodeling. Osteocytes play a critical role in remodeling during OTM, as they have been described source of nuclear factor-κB ligand (RANKL) necessary for OTM. Tumor necrosis factor (TNF)-α cytokine that acts amplifying RANKL expression osteocytes. In this study, we evaluated effects TNF-α osteocyte