A5046478055- Bone Metabolism and Diseases
- Neuropeptides and Animal Physiology
- Bone health and treatments
- Inflammatory mediators and NSAID effects
- Orthodontics and Dentofacial Orthopedics
- Renin-Angiotensin System Studies
- Biochemical Analysis and Sensing Techniques
- MicroRNA in disease regulation
- Thyroid Disorders and Treatments
- Sodium Intake and Health
- Peptidase Inhibition and Analysis
- Cytokine Signaling Pathways and Interactions
- Receptor Mechanisms and Signaling
- dental development and anomalies
- Medicinal Plant Pharmacodynamics Research
- Regulation of Appetite and Obesity
Tohoku University
2023-2025
United States Department of Veterans Affairs
1987-1988
Icahn School of Medicine at Mount Sinai
1987
Tumor necrosis factor-alpha (TNF-α) is a significant cytokine that regulates bone resorption under inflammatory conditions. However, its mechanism of action in osteocytes remains unclear. In this study, highly purified were isolated from dentin matrix protein 1 (DMP1)-Topaz mice using cell sorter. RNA sequencing (RNA-seq) revealed TNF-α stimulation increased C-X-C motif chemokine ligand 10 (CXCL10) gene expression osteocytes. Although CXCL10 did not affect osteoclast differentiation vitro,...
Background/Objective: Osteocytes are the most abundant cell type in skeleton, with key endocrine functions, particularly regulating osteoblast and osteoclast activity to maintain bone quality. Angiotensin II (Ang II), a critical component of renin–angiotensin–aldosterone system, is well-known for its role vasoconstriction during hypertension. Beyond cardiovascular Ang participates various biological processes, including metabolism. While influence on proliferation, differentiation,...
Abstract Renin–angiotensin–aldosterone system plays a crucial role in the regulation of blood pressure and fluid homeostasis. It is reported to be involved mediating osteoclastogenesis bone loss diseases inflammatory resorption such as osteoporosis. Angiotensin-(1–7), product Angiotensin I II (Ang I, II), cleaved by Angiotensin-converting enzyme 2 then binds Mas receptor counteract effects produced Ang II. However, mechanism which Ang-(1–7) reduces remains unclear. Therefore, we aim...
Hypertension is a major risk factor for cardiovascular disease (CVD) and associated with increased bone loss due to excessive activity of the local renin-angiotensin system (RAS). Angiotensinogen/Angiotensin (ANG) II/Angiotensin II type 1 receptor (AT1R) axis considered as core regulating RAS activity. Azilsartan an FDA-approved selective AT1R antagonist that used treat hypertension. This study aimed determine whether azilsartan affects formation osteoclast, resorption bone, expression...
Glucose-insulinotropic polypeptide (GIP) is an incretin hormone that induces insulin secretion and decreases blood glucose levels. In addition, it has been reported to suppress osteoclast formation. Native GIP rapidly degraded by dipeptidyl peptidase-4 (DPP-4). (D-Ala2)GIP a newly developed analog demonstrates enhanced resistance DPP-4. This study aimed evaluate the influence of on formation bone resorption during lipopolysaccharide (LPS)-induced inflammation in vivo vitro. vivo, mice...