A5015434900- Neuroinflammation and Neurodegeneration Mechanisms
- COVID-19 Impact on Reproduction
- Vaccine Coverage and Hesitancy
- Immune cells in cancer
- HIV Research and Treatment
- Neurogenesis and neuroplasticity mechanisms
- Mosquito-borne diseases and control
- GDF15 and Related Biomarkers
- Maternal Mental Health During Pregnancy and Postpartum
- SARS-CoV-2 and COVID-19 Research
- Reproductive System and Pregnancy
- Birth, Development, and Health
- interferon and immune responses
Icahn School of Medicine at Mount Sinai
2022-2024
Radboud University Nijmegen
2024
Radboud University Medical Center
2024
Prenatal infections and activation of the maternal immune system have been proposed to contribute causing neurodevelopmental disorders (NDDs), chronic conditions often linked brain abnormalities. Microglia are resident cells play a key role in neurodevelopment. Disruption microglial functions can lead abnormalities increase risk developing NDDs. How as well fetal affect human neurodevelopment NDDs remains unclear. An important reason for this knowledge gap is fact that impact exposure...
Our mouse model is a powerful tool for investigating the genetic mechanisms governing central nervous system (CNS) human immunodeficiency virus type-1 (HIV-1) infection and latency in CNS at single-cell level. A major advantage of our that it uses induced pluripotent stem cell-derived microglia, which enables genetics, including gene function therapeutic manipulation, to be explored
The central nervous system (CNS) is a major human immunodeficiency virus type 1 reservoir. Microglia are the primary target cell of HIV-1 infection in CNS. Current models have not allowed precise molecular pathways acute and chronic CNS microglial to be tested with vivo genetic methods. Here, we describe novel humanized mouse model utilizing human-induced pluripotent stem cell-derived microglia xenograft into murine hosts. These mice additionally engrafted peripheral blood mononuclear cells...
We examined differences in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody responses pregnant individuals with natural, vaccine-induced, or combined immunity. Participants had live nonlive births between 2020 and 2022, were seropositive (SARS-CoV-2 spike protein, anti-S), available mRNA vaccination infection information (n=260). compared titer levels among three immunity profiles: 1) natural (n=191), 2) vaccine-induced (n=37), 3) (ie, immunity; n=32). applied linear...