Alexandra Mills
A5042436392- Antimicrobial Resistance in Staphylococcus
- Bacterial Identification and Susceptibility Testing
- Mycobacterium research and diagnosis
- Acute Kidney Injury Research
- Streptococcal Infections and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Medical Device Sterilization and Disinfection
- Reproductive Health and Technologies
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Assisted Reproductive Technology and Twin Pregnancy
- COVID-19 Impact on Reproduction
- Bacterial biofilms and quorum sensing
- Pregnancy and preeclampsia studies
- Reproductive Biology and Fertility
- Pneumocystis jirovecii pneumonia detection and treatment
- Maternal and Perinatal Health Interventions
- Molecular Biology Techniques and Applications
- Birth, Development, and Health
- Sinusitis and nasal conditions
- Abdominal Surgery and Complications
- Oral microbiology and periodontitis research
- Grief, Bereavement, and Mental Health
- Antibiotic Resistance in Bacteria
- GDF15 and Related Biomarkers
- Maternal Mental Health During Pregnancy and Postpartum
Icahn School of Medicine at Mount Sinai
2019-2024
Mount Sinai Hospital
2020
Abstract Background This study aimed to determine the impact of preoperative exposure intravenous contrast for CT and risk developing postoperative acute kidney injury (AKI) in patients undergoing major gastrointestinal surgery. Methods prospective, multicentre cohort included adults resection, stoma reversal or liver resection. Both elective emergency procedures were included. Preoperative was defined as administered purposes up 7 days before The primary endpoint rate AKI within days....
Abstract Background Whole-genome sequencing (WGS) is increasingly used to map the spread of bacterial and viral pathogens in nosocomial settings. A limiting factor for more widespread adoption WGS hospital infection prevention practices availability standardized tools genomic epidemiology. Methods We developed Pathogen Sequencing Phylogenomic Outbreak Toolkit (PathoSPOT) automate integration medical record data rapid detection tracing outbreaks. To demonstrate its capabilities, we applied...
Abstract Background The intermediate-term impact of acute kidney injury (AKI) in patients after major gastrointestinal and liver surgery has not been well characterized. This study aimed to evaluate the 1-year mortality rate renal outcomes associated with postoperative AKI a national prospective cohort. Methods multicentre, observational cohort follow-up included adults undergoing across UK Ireland between 23 September 18 November 2015. was defined according Kidney Disease Improving Global...
Abstract This case–control study of 25 cases with methicillin-resistant Staphylococcus aureus (MRSA) bacteremia vancomycin minimum inhibitory concentration (MIC) ≥ 2 µg/mL and 391 controls (MIC < µg/mL) characterized the clinical characteristics, treatments, outcomes associated elevated MIC. Elevated MIC was baseline hemodialysis, prior MRSA colonization, metastatic infection.
Background: Candida auris is an opportunistic pathogen reported in the US since 2016. C. infections (CAI) are frequently healthcare-associated, but only one case of donor-derived CAI a lung transplant recipient has been (PMID 28520901). We describe cluster two CAIs at single center South Carolina occurring 2 different recipients from same solid organ donor. Methods: cases invasive academic medical without prior Charleston, SC October 2023. was identified using Bruker MALDI-TOF and confirmed...
Placenta accreta spectrum (PAS) disorder is a source of severe obstetric morbidity and mortality worldwide. The objective this paper was to evaluate the potential relationship between social vulnerability maternal in cohort patients delivering pregnancy complicated by PAS. A retrospective review 323 deliveries at three academic medical institutions January 2013 June 2022 included analyses. Patients were those with histopathologically confirmed case composite outcome such complications as...
Postoperative acute kidney injury (AKI) is a common complication of major gastrointestinal surgery with an impact on short- and long-term survival. No validated system for risk stratification exists this patient group. This study aimed to validate externally prognostic model AKI after in two multicentre cohort studies.The Outcomes After Kidney Surgery (OAKS) was developed predict the 7 days using six routine datapoints (age, sex, ASA grade, preoperative estimated glomerular filtration rate,...
Healthcare-associated infections pose a potentially fatal threat to patients worldwide and Staphylococcus aureus is one of the most common causes healthcare-associated infections. S. commensal pathogen frequent cause bacteremia, with studies demonstrating that nasal blood isolates from single match more than 80% time. Here we report on contemporary collection colonizing those methicillin-resistant (MRSA) bloodstream evaluate diversity within hosts, detail clinical features associated...
Abstract Whole genome sequencing (WGS) is increasingly used to map the spread of bacterial and viral pathogens in nosocomial settings. A limiting factor for more widespread adoption WGS hospital infection prevention practices availability standardized tools genomic epidemiology. Here we present Pathogen Sequencing Phylogenomic Outbreak Toolkit (PathoSPOT), which automates integration medical record data rapid detection tracing outbreaks. To demonstrate its capabilities applied PathoSPOT...
Abstract Background. Healthcare-associated infections pose a potentially fatal threat to patients worldwide and Staphylococcus aureus is one of the most common causes healthcare-associated infections. S. commensal pathogen frequent cause bacteremia, with studies demonstrating that nasal blood isolates from single match more than 80% time. Here we report on contemporary collection colonizing those methicillin-resistant (MRSA) bloodstream evaluate diversity within hosts, detail clinical...
INTRODUCTION: Antenatal SARS-CoV-2 infection causes significant maternal morbidity and mortality. Preeclampsia share common pathophysiology that may worsen pregnancy outcomes when both coexist. The purpose of this study was to investigate the effect gestational on risk developing hypertensive disease (pregnancy-induced hypertension [PIH]). METHODS: We performed a 307 participants from IRB-approved Generation C prospective cohort in New York City designed examine maternal, fetal, neonatal...
Abstract Background Staphylococcus aureus is a common commensal pathogen and frequent cause of bacteremia, with nasal blood isolates from single patients matching >80% the time. Based on our prior work paired single-patient isolates,1 aim was to collect contemporary set colonizing those methicillin-resistant S. (MRSA) bloodstream infections (BSIs), evaluate within-host diversity by whole-genome sequencing (WGS), detail clinical features linked colonization. Methods Adult MRSA BSIs were...
Abstract Background Methicillin-resistant Staphylococcus aureus (MRSA) is a serious nosocomial pathogen, and listed as “High Priority Pathogen” by the WHO due to concerns of antimicrobial resistance lack novel therapeutics. Even in vancomycin-susceptible MRSA, increased rates treatment failure occur setting an minimum inhibitory concentration (MIC) vancomycin, which considered gold-standard therapy. We performed case series 25 patients infected with MRSA elevated MIC vancomycin....