A5053714212- Antimicrobial Resistance in Staphylococcus
- Bacterial Identification and Susceptibility Testing
- Streptococcal Infections and Treatments
- Antibiotic Resistance in Bacteria
- Mycobacterium research and diagnosis
- Medical Device Sterilization and Disinfection
- Infection Control in Healthcare
- Infection Control and Ventilation
- Antibiotic Use and Resistance
- COVID-19 Clinical Research Studies
- Clostridium difficile and Clostridium perfringens research
- Oral microbiology and periodontitis research
- Microbial infections and disease research
- Cancer Treatment and Pharmacology
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Vibrio bacteria research studies
- Electroconvulsive Therapy Studies
- Aerodynamics and Fluid Dynamics Research
- Zoonotic diseases and public health
- Bacillus and Francisella bacterial research
- Sepsis Diagnosis and Treatment
- Healthcare and Environmental Waste Management
- Respiratory and Cough-Related Research
- Bacterial biofilms and quorum sensing
- Sinusitis and nasal conditions
Icahn School of Medicine at Mount Sinai
2018-2023
Baptist Hospital of Miami
2022
Baptist Health South Florida
2022
Mount Sinai Hospital
2019-2020
Jackson Memorial Hospital
2014-2017
University of Miami Hospital
2017
University of Miami
2014-2016
Engineering Associates (United States)
2016
Previous viral pandemics have shown that secondary bacterial infections result in higher morbidity and mortality, with Staphylococcus aureus being the primary causative pathogen. The impact of S. bacteremia on mortality patients infected severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains unknown.This was a retrospective observational case series disease 2019 (COVID-19) who developed across New York City hospitals. end point to describe 14-day 30-day hospital rates COVID-19...
OBJECTIVE To concomitantly determine the differential degrees of air and environmental contamination by Acinetobacter baumannii based on anatomic source colonization type ICU layout (single-occupancy vs open layout). DESIGN Longitudinal prospective surveillance study surfaces in patient rooms. SETTING A 1,500-bed public teaching hospital Miami, Florida. PATIENTS Consecutive A. –colonized patients admitted to our ICUs between October 2013 February 2014. METHODS Air rooms were sampled daily...
Abstract Background Whole-genome sequencing (WGS) is increasingly used to map the spread of bacterial and viral pathogens in nosocomial settings. A limiting factor for more widespread adoption WGS hospital infection prevention practices availability standardized tools genomic epidemiology. Methods We developed Pathogen Sequencing Phylogenomic Outbreak Toolkit (PathoSPOT) automate integration medical record data rapid detection tracing outbreaks. To demonstrate its capabilities, we applied...
Methicillin-resistant Staphylococcus aureus (MRSA) causes life-threatening infections in both community and hospital settings is a leading cause of health care-associated (HAIs). We sought to describe the molecular epidemiological landscape patients with MRSA bloodstream (BSIs) at an urban medical center by evaluating clinical characteristics associated two dominant endemic clones.Comprehensive data from electronic records 227 hospitalized ≥18 years old BSI over 33-month period New York City...
Background The global pandemic caused by severe acute respiratory syndrome coronavirus 2 resulted in a large burden of critically ill patients, population with an increased risk both developing and dying from secondary infections. We investigated the clinical characteristics, factors, outcomes associated bloodstream infections (BSIs) among those admitted to intensive care unit (ICU) for disease 2019 (COVID-19) during peak first surge New York City, before standardization treatment regimens...
Abstract This case–control study of 25 cases with methicillin-resistant Staphylococcus aureus (MRSA) bacteremia vancomycin minimum inhibitory concentration (MIC) ≥ 2 µg/mL and 391 controls (MIC < µg/mL) characterized the clinical characteristics, treatments, outcomes associated elevated MIC. Elevated MIC was baseline hemodialysis, prior MRSA colonization, metastatic infection.
Healthcare-associated infections pose a potentially fatal threat to patients worldwide and Staphylococcus aureus is one of the most common causes healthcare-associated infections. S. commensal pathogen frequent cause bacteremia, with studies demonstrating that nasal blood isolates from single match more than 80% time. Here we report on contemporary collection colonizing those methicillin-resistant (MRSA) bloodstream evaluate diversity within hosts, detail clinical features associated...
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Abstract Background Methicillin-resistant Staphylococcus aureus (MRSA) causes life-threatening infections in both community and hospital settings is a leading cause of healthcare-associated (HAIs). We sought to describe the molecular epidemiological landscape patients with MRSA bloodstream (BSIs) at an urban medical center by evaluating clinical characteristics associated two dominant endemic clones. Methods Comprehensive data extraction from electronic health records 227 hospitalized ≥18...
Abstract Whole genome sequencing (WGS) is increasingly used to map the spread of bacterial and viral pathogens in nosocomial settings. A limiting factor for more widespread adoption WGS hospital infection prevention practices availability standardized tools genomic epidemiology. Here we present Pathogen Sequencing Phylogenomic Outbreak Toolkit (PathoSPOT), which automates integration medical record data rapid detection tracing outbreaks. To demonstrate its capabilities applied PathoSPOT...
Abstract Background. Healthcare-associated infections pose a potentially fatal threat to patients worldwide and Staphylococcus aureus is one of the most common causes healthcare-associated infections. S. commensal pathogen frequent cause bacteremia, with studies demonstrating that nasal blood isolates from single match more than 80% time. Here we report on contemporary collection colonizing those methicillin-resistant (MRSA) bloodstream evaluate diversity within hosts, detail clinical...
Abstract Background Staphylococcus aureus is a common commensal pathogen and frequent cause of bacteremia, with nasal blood isolates from single patients matching >80% the time. Based on our prior work paired single-patient isolates,1 aim was to collect contemporary set colonizing those methicillin-resistant S. (MRSA) bloodstream infections (BSIs), evaluate within-host diversity by whole-genome sequencing (WGS), detail clinical features linked colonization. Methods Adult MRSA BSIs were...
Caban, Ana Berbel; Davis, Nicole; Reilly, Kaitlin; Waqar, Omar; Jin, Haoli; Smith, Tukisa Author Information
Abstract Background Methicillin-resistant Staphylococcus aureus (MRSA) is a serious nosocomial pathogen, and listed as “High Priority Pathogen” by the WHO due to concerns of antimicrobial resistance lack novel therapeutics. Even in vancomycin-susceptible MRSA, increased rates treatment failure occur setting an minimum inhibitory concentration (MIC) vancomycin, which considered gold-standard therapy. We performed case series 25 patients infected with MRSA elevated MIC vancomycin....
Abstract Background Methicillin-resistant Staphylococcus aureus (MRSA) is a common cause of health-care associated infections, particularly bloodstream infections (BSI). Concomitant colonization the anterior nares has been shown to have implications on persistence, recurrence, and transmission events. We performed genomic comparisons between paired nasal blood MRSA isolates obtained from same patient elucidate genetic differences that may contribute within-host invasion virulence. Methods...