Eric Deneuville
A5109438415- Cystic Fibrosis Research Advances
- Tracheal and airway disorders
- Neonatal Respiratory Health Research
- Pneumonia and Respiratory Infections
- Pediatric health and respiratory diseases
- Respiratory viral infections research
- Asthma and respiratory diseases
- Pneumocystis jirovecii pneumonia detection and treatment
- Tuberculosis Research and Epidemiology
- Antifungal resistance and susceptibility
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Nematode management and characterization studies
- Antibiotics Pharmacokinetics and Efficacy
- Fungal Infections and Studies
- Dysphagia Assessment and Management
- Child Nutrition and Feeding Issues
- Infant Nutrition and Health
- Medical Imaging and Pathology Studies
- Genetic and Kidney Cyst Diseases
- Breastfeeding Practices and Influences
- Lung Cancer Diagnosis and Treatment
- Antibiotic Resistance in Bacteria
- Family and Disability Support Research
- HIV/AIDS drug development and treatment
- Pediatric Hepatobiliary Diseases and Treatments
Centre Hospitalier Universitaire de Rennes
2007-2025
CIC Rennes
2015
Hôpital Nord
2006-2009
Université de Reims Champagne-Ardenne
1997
Inserm
1997
Centre Hospitalier Universitaire de Reims
1997
ABSTRACT The present multicenter, randomized crossover study compared the safety and efficacy of continuous infusion with those short infusions ceftazidime in patients cystic fibrosis. Patients chronic Pseudomonas aeruginosa colonization received two successive courses intravenous tobramycin (200 mg/kg body weight/day) for pulmonary exacerbation administered as thrice-daily or a infusion. primary endpoint was variation forced expiratory volume 1 s (FEV ) during course antibiotic treatment....
The diagnosis of cystic fibrosis (CF) is based on a characteristic clinical picture in association with sweat chloride (Cl(-)) concentration greater than 60 mmol/L or the identification two CF-causing mutations. A challenging problem significant number children for whom no definitive possible because they present symptoms suggestive CF, level intermediate range between 30 and mmol/L, only one identified mutation.To investigate function transmembrane conductance regulator (CFTR) protein...
Highly effective CFTR modulators, such as elexacaftor/tezacaftor/ivacaftor (ETI), herald a new era in therapeutic strategy of cystic fibrosis (CF). ETI impact on glucose tolerance remains controversial. All the participants underwent baseline oral test (OGTT) before initiation (M0) and 12 months (M12), at 24 if possible. The cohort was stratified two subgroups based OGTT: normal (NGT) abnormal (AGT) defined by impaired fasting or diabetes not requiring insulin treatment. We included 106...
Elexacaftor/tezacaftor/ivacaftor (ETI) is a Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) therapy that improves pulmonary function and chronic rhinosinusitis (CRS) in cystic fibrosis (CF) adults with at least one copy of the F508del CFTR mutation. The purpose this study to evaluate impact ETI on CRS symptoms children adolescents CF. MODUL-CF observational multicenter prospective cohort enrolling CF 1 mutation France. Subjects answered standardized questionnaire nasal obstruction...
Interstitial lung disease in children (chILD) are rare and mostly severe diseases. Very few epidemiological data available limited series of patients. The aim this study was to assess the prevalence incidence chILD France.
Aspergillus fumigatus triazole resistance is an emerging concern for treating chronically infected/colonized patients. This study sought to evaluate the performance of PCR assays detect fungi together with azole in sputum samples from cystic fibrosis (CF) In total, 119 87 CF patients were prospectively processed detection by means mycological culture and four qPCR assays, 2 in-house methods two commercial multiplex real-time simultaneously detecting most relevant cyp51A gene mutations...
We investigated the physicochemical and transport properties of sputum samples collected in physiotherapy from a well-documented group 27 cystic fibrosis (CF) patients with identified CF genotypes. Sputum were characterized ex vivo for their water content, surface (surface tension contact angle), rheologic (viscosity elastic modulus), (mucociliary cough transport). These data analyzed relation to clinical status (FEV1, FVC, Shwachman score, Brasfield nutritional status), genotype, degree...
Viral infections such as influenza are thought to impact respiratory parameters and promote infection with Pseudomonas aeruginosa in patients cystic fibrosis (CF). However, the real morbidity of virus CF needs be further investigated because previous studies were only observational. included a case–control study (n = 44 cases n 371 controls) during 2009 pandemic A/H1N1 influenza. Cases polymerase reaction chain-confirmed infection. Controls did not report any symptoms same period. Sputum...
Abstract Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections are closely monitored in people with cystic fibrosis (pwCF), especially severe cases. Previous studies used hospitalization rates as proxy for severity. Methods We evaluated data from disease 2019 (COVID-19) cases diagnosed French pwCF over the first pandemic year. Objective criteria were applied defining severity (eg, failure and/or death). Data compared to all using National Registry. Results As of...
Abstract Background Cystic fibrosis (CF) is caused by mutations in the gene encoding for CF transmembrane conductance regulator (CFTR) protein, which acts as a chloride channel after activation cyclic AMP (cAMP). Newborn screening programs usually consist of an immunoreactive trypsinogen (IRT) assay, followed when IRT elevated testing panel CF-causing mutations. Some children, however, may have persistent hypertrypsinogenemia, only one or no identified CFTR mutation, and sweat concentrations...
Lung damage in cystic fibrosis (CF) is strongly associated with lower airway infections. Early treatment of Pseudomonas aeruginosa recommended. Pathogen detection requires sampling secretions, which remains a challenge nonexpectorating patients. Our hypothesis was that chest physiotherapy would improve the quality secretion samples and increase rates pathogens detected This prospective multicentre study compared three successive methods for secretions applied through same session: 1) an...
In the management of cystic fibrosis, treatments against Staphylococcus aureus and Haemophilus influenzae such as amoxicillin or cotrimoxazole have to be prescribed antibiotherapy's efficacy may linked concentration that reaches infected site. As fibrosis patients present disturbed pharmacokinetics parameters, drug monitoring would relevant assess lung distribution antibiotics optimize dosing regimens. this context, aim study was develop validate HPLC-based methods for determination both in...
<b>Introduction:</b> Interstitial lung disease (ILD) in children (chILD) is rare and often severe. This study aims at analyzing the epidemiology of chILD France from 2000 to 2022. <b>Methods:</b> was retrospective multicentric. A questionnaire sent all RespiRare centers collect clinical, radiological, biological, histological genetic data patients. <b>Results:</b> 617 patients (0-18 years) were included 42 centers. 84 excluded. The median age diagnosis 0.3 years with 17% familial forms. main...