A5041351296- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Immune cells in cancer
- Cancer Cells and Metastasis
- Cancer, Stress, Anesthesia, and Immune Response
- Adolescent and Pediatric Healthcare
- Cancer-related molecular mechanisms research
- Rheumatoid Arthritis Research and Therapies
- Mental Health and Patient Involvement
- Interprofessional Education and Collaboration
- Systemic Lupus Erythematosus Research
- Systemic Sclerosis and Related Diseases
- Genetic Syndromes and Imprinting
- Cell Adhesion Molecules Research
- Medical Imaging and Pathology Studies
- Lung Cancer Treatments and Mutations
- Inflammatory Myopathies and Dermatomyositis
- Circular RNAs in diseases
- Cancer therapeutics and mechanisms
- Musculoskeletal synovial abnormalities and treatments
University of Zurich
2023-2025
University Hospital of Zurich
2023-2025
University of Crete
2022
Leiden University Medical Center
2020
G. Papanikolaou General Hospital
2017
Abstract Purpose: Endoglin is a coreceptor for TGFβ ligands that highly expressed on proliferating endothelial cells and other in the tumor microenvironment. Clinical studies have noted increased programmed cell death (PD)-1 expression cytotoxic T peripheral blood of patients with cancer treated TRC105, an endoglin-targeting antibody. In this study, we investigated combination endoglin antibodies (TRC105 M1043) anti-PD1 Experimental Design: The anti-endoglin/anti-PD1 was tested four...
Background Patient research partners (PRPs) are people living with a relevant disease who actively contribute to research. Their contribution is beneficial for any project. Although the inclusion of PRPs in rheumatology increasingly recommended, its practical implementation, particularly translational research, remains limited . Enhancing PRP engagement requires clear understanding necessary steps. Objective This study aims show steps achieve successful collaboration between and researchers...
Single-cell RNA sequencing (scRNAseq) of human tissues has expanded our understanding the complexity cellular subsets and their changes in disease. The availability scRNAseq data different disease states provides an opportunity to compare identify common unique activation. In this study, we aimed characterize shared tissue-specific myeloid stromal phenotypes uncover key subtypes involved pathogenic tissue We analyzed from 14 public datasets, comprising heart, lung, skin, synovium both...
Abstract Although patients with rheumatoid arthritis (RA) typically exhibit symmetrical joint involvement, some develop alternative disease patterns in response to treatment, suggesting that different molecular mechanism may underlie progression depending on location. Here, we identify joint-specific changes RA synovium and synovial fibroblasts (SF) between knee hand joints. We show the long non-coding RNA HOTAIR, which is only expressed SF, regulates more than 50% of this site-specific gene...
<h3>Background:</h3> Distinct synovial fibroblasts (SF) subtypes in the synovium of patients with rheumatoid arthritis (RA) have been previously described. While there is evidence their immune–effector properties, interaction infiltrating immune cells and role inflammatory process remain poorly understood. The contribution immune-effector SF subsets may be involved poor patient response to treatment. <h3>Objectives:</h3> To identify a subtype potential pro-inflammatory properties unravel its...
The majority of cases lung cancer are still diagnosed at a late stage. At this stage, palliative therapeutic options including nonspecific cytotoxic drugs, targeted therapy, or immunotherapy can be utilized. In 2016, was approved in Europe for squamous cell carcinoma and adenocarcinoma. Moreover, afatinib also as second-line therapy carcinoma.This article presents case 76-year-old male with who received nab-paclitaxel first-line his treatment switched to the tyrosine kinase inhibitor (40 mg)...
<p>Supplementary figures S1-S5</p>
<div>AbstractPurpose:<p>Endoglin is a coreceptor for TGFβ ligands that highly expressed on proliferating endothelial cells and other in the tumor microenvironment. Clinical studies have noted increased programmed cell death (PD)-1 expression cytotoxic T peripheral blood of patients with cancer treated TRC105, an endoglin-targeting antibody. In this study, we investigated combination endoglin antibodies (TRC105 M1043) anti-PD1 antibody.</p>Experimental Design:<p>The...
<div>AbstractPurpose:<p>Endoglin is a coreceptor for TGFβ ligands that highly expressed on proliferating endothelial cells and other in the tumor microenvironment. Clinical studies have noted increased programmed cell death (PD)-1 expression cytotoxic T peripheral blood of patients with cancer treated TRC105, an endoglin-targeting antibody. In this study, we investigated combination endoglin antibodies (TRC105 M1043) anti-PD1 antibody.</p>Experimental Design:<p>The...
<p>Supplementary figures S1-S5</p>