A5085138365- Adipose Tissue and Metabolism
- Head and Neck Anomalies
- Per- and polyfluoroalkyl substances research
- Thyroid Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Prostate Cancer Treatment and Research
- MicroRNA in disease regulation
- Cerebrovascular and genetic disorders
- Effects and risks of endocrine disrupting chemicals
- Circular RNAs in diseases
- Mesenchymal stem cell research
- S100 Proteins and Annexins
- Lipid metabolism and biosynthesis
- Bone Tumor Diagnosis and Treatments
Charles University
2016-2018
University Hospital Plzen
2017
Background/Aim: Current research of prostate cancer (PCa) offers a promising way identifying patients with adverse prognosis who do benefit from radical treatment that can affect quality life as resections are associated numerous side-effects. The aim our study was to evaluate the relationship TMPRSS2-ERG fusion gene status, tumor tissue prostate-specific antigen (PSA), 3 (PCA3), miR-23b, miR-26a and miR-221 expression levels in combination preoperative serum PSA level risk PCa recurrence...
MicroRNAs have the potential to become valuable predictive markers for gastric cancer. Samples of biopsy tissue, routinely taken from cancer patients undergoing palliative chemotherapy, constitute suitable material microRNA profiling with aim predicting effect chemotherapy. Our study group consisted 54 patients, all whom underwent chemotherapy based on 5-fluorouracil (5-FU) or 5-FU in combination platinum derivatives between 2000 and 2013. The expression 29 selected microRNAs genes BRCA1,...
Evidence indicating, that persistent organic pollutants are involved in the development of obesity, has emerged. The aim this study was to reveal whether an environmental bioaccumulative human adipose tissue contaminant, 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE), affects adipocyte differentiation. Our conducted on vitro adipogenic model derived mesenchymal stem cells (hADMSC). cultures were exposed DDE (concentrations: 0.1 μM, 1 and 10 μM) for 28 consecutive days, from beginning...