A5033829858- interferon and immune responses
- Influenza Virus Research Studies
- Animal Virus Infections Studies
- Immune Response and Inflammation
- Virology and Viral Diseases
- HIV Research and Treatment
- Advanced materials and composites
- Herpesvirus Infections and Treatments
- Cytokine Signaling Pathways and Interactions
- CRISPR and Genetic Engineering
- Virus-based gene therapy research
- Tunneling and Rock Mechanics
- Kawasaki Disease and Coronary Complications
- Inflammasome and immune disorders
- Mosquito-borne diseases and control
- Animal Disease Management and Epidemiology
- Viral gastroenteritis research and epidemiology
- Orthopaedic implants and arthroplasty
- Invertebrate Immune Response Mechanisms
- Microbial infections and disease research
- Cytomegalovirus and herpesvirus research
- Advanced ceramic materials synthesis
- Structural Engineering and Vibration Analysis
- Aluminum Alloys Composites Properties
- Urban Transport and Accessibility
Center of Hubei Cooperative Innovation for Emissions Trading System
2022-2025
Huazhong Agricultural University
2013-2025
Shandong Academy of Sciences
2023
Qilu University of Technology
2023
Nanjing Tech University
2022
Beijing Jiaotong University
2013
Host genes critical for viral infection are effective antiviral drug targets with tremendous potential due to their universal characteristics against different subtypes of viruses and minimization resistance. Accordingly, we execute a genome-wide CRISPR-Cas9 screen multiple rounds survival selection. Enriched in this several host sialic acid biosynthesis transportation, including the cytohesin 2 (CYTH2), tetratricopeptide repeat protein 24 (TTC24), N-acetylneuraminate synthase (NANS), which...
ABSTRACT Bovine herpesvirus (BoHV) infection poses a significant threat to the healthy development of cattle industry. BoHV-1 primarily causes infectious bovine rhinotracheitis, while BoHV-5 is associated with necrotic meningoencephalitis. These two pathogens not only exhibit high correlation in antigenicity and genetic background but, more importantly, can establish latent infections within ganglion. Therefore, establishing rapid convenient pathogen detection method for crucial early...
The 2009 pandemic H1N1 influenza virus (pdm/09) is typically mildly virulent in mice. In a previous study, we identified four novel swine isolates of pdm/09 viruses that exhibited high lethality Comparing the consensus sequences PB2 subunit human with those isolate revealed one mutation: T588I. this determined 588T an amino acid mutation conserved was exceedingly rare isolates. To investigate whether T5581 (PB2-T558I) has effect on increased pathogenicity, rescued variant containing PB2-588I...
The influenza A virus (IAV) can be recognized by retinoic acid-inducible gene I (RIG-I) to activate the type interferon response and induce antiviral effects. has evolved several strategies evade innate immune response, including non-structural protein 1 (NS1) its polymerase subunits. mechanism which NS1 inhibits interferon-β (IFN-β) is well understood, whereas acid (PA) IFN-β remains elucidated. In this study, we observed that IAV PA could inhibit production of interferon-stimulated genes...
Viral infection triggers a series of signaling cascades and host innate immune responses, including interferon (IFN) production, which depends on coordinated activity multiple transcription factors. IFN regulatory factor 3 (IRF3) transcriptional coactivator CREB binding protein (CBP) and/or p300 are core factors that participate in complex formation the nucleus. In general, cells balance production IFNs through suppressive stimulative mechanisms, but viral infections can disrupt such...
Duck Tembusu virus (DTMUV) is a newly emerging pathogenic flavivirus that has caused huge economic losses to the duck industry in China since 2010. Moreover, infection spread rapidly, posing potential public health concern. In this study, iTRAQ approach was first used quantitatively identify differentially expressed cellular proteins DTMUV‐infected BHK‐21 cells which are usually employed produce veterinary vaccines for DTMUV, as well other flaviviruses by serial passage. We identified 192...
Multiple compounds are related to the development of liver injury, such as toxins, drugs, and environmental pollutants. Although there reports that T-2 toxin can cause its toxic mechanism remains unclear, which further impedes effective antidotes. In this study, CRISPR-Cas9 genome-wide screening technology was used identify transformation-related protein 53 inducible nuclear 1 (trp53inp1) a target toxin. Mechanism studies have shown induced pyroptosis macrophages (J774A.1 cells) by...
Multiple outbreaks of avian infectious laryngotracheitis (ILT) in chickens, both domestically and internationally, have been directly correlate to widespread vaccine use affected countries regions. Phylogenetic recombination event analyses demonstrated that virus (ILTV) field strains are progressively evolving toward the chicken embryo-origin (CEO) strain. Even with standardized biosecurity measures effective prevention control strategies implemented on large-scale farms, continuous ILT...
This study evaluates the level of sustainable development for railway transportation based on back-propagation (BP) neural network. Four aspects, which cover conception economy, society, environment and resource, are considered when constructing index system, is optimized through Principle Component Analysis. An evaluation model BP network constructed enterprise in China taken as case, results show that creditable effective. The reveal trend gradually upward despite a low overall level,...
Streptococcus suis (S. suis) is an emerging zoonotic pathogen that can cause multiple diseases, including streptococcal toxic shock-like syndrome (STSLS). The S. SC-19 strain could NOD-like receptor thermal protein domain-associated 3 (NLRP3) inflammasome hyperactivation, then induce a cytokine storm and STSLS. Although IL-18 the downstream effector of NLRP3 signaling, role signaling on STSLS remains to be elucidated. Thus, il18r1 gene knockout mice were constructed challenged with strain....
<p>In order to determine the rational cable force of extradosed bridge, a comprehensive optimization method is proposed. The based on influence matrix and adopts data standardization change two or more different types discrete into dimensionless uniform data, with objective minimizing combined displacement bending moment structural control section. Relying bridge Nanjing Intercity Rail Transit Ningju Line as an engineering example, results show that calculated integrated can reduce...