A5001181260- Poxvirus research and outbreaks
- SARS-CoV-2 and COVID-19 Research
- Herpesvirus Infections and Treatments
- SARS-CoV-2 detection and testing
- Bacillus and Francisella bacterial research
- COVID-19 Clinical Research Studies
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Vaccine Coverage and Hesitancy
- Enhanced Recovery After Surgery
- Autoimmune Neurological Disorders and Treatments
- Biosensors and Analytical Detection
- Respiratory viral infections research
- HIV, Drug Use, Sexual Risk
- Vector-Borne Animal Diseases
- COVID-19 epidemiological studies
- Genital Health and Disease
- HIV-related health complications and treatments
- Elder Abuse and Neglect
- Adolescent Sexual and Reproductive Health
- Healthcare Systems and Challenges
- Infectious Encephalopathies and Encephalitis
- Pharmacological Effects and Toxicity Studies
- Sexual Assault and Victimization Studies
Chelsea and Westminster Hospital NHS Foundation Trust
2021-2024
Government of the United Kingdom
2022
Chelsea and Westminster Hospital
2022
St George's, University of London
2021
NIHR Imperial Biomedical Research Centre
2021
North West London Pathology
2021
Royal Navy
2021
St George’s University Hospitals NHS Foundation Trust
2021
Imperial College London
2021
Imperial College Healthcare NHS Trust
2021
Background: Human monkeypox virus (MPXV) cases in UK have been mainly due to imported infections from West Africa. and several other countries are now reporting increasing number of individuals with no apparent epidemiological links areas where the is endemic.Methods: We report clinical features patients confirmed MPVX infection via MPXV viral PCR detection who attended open-access sexual health clinics London, UK. hospitalization rates concurrent STI we describe our response...
Abstract Background Older adults, particularly in long-term care facilities (LTCF), remain at considerable risk from SARS-CoV-2. Data on the protective effect and mechanisms of hybrid immunity are skewed towards young adults precluding targeted vaccination strategies. Methods A single-centre longitudinal seroprevalence vaccine response study was conducted with 280 LCTF participants (median 82 yrs, IQR 76-88 yrs; 95.4% male). Screening by SARS-CoV-2 polymerase chain reaction weekly...
Real-world evaluation of the performance Innova lateral flow immunoassay antigen device (LFD) for regular COVID-19 testing hospital workers.This prospective cohort analysis took place at a London NHS Trust. 5076 secondary care healthcare staff participated in LFD from 18 November 2020 to21 January 2021. Staff members submitted results and symptoms via an online portal twice weekly. Individuals with positive were invited confirmatory SARS CoV-2 PCR testing. The predictive value (PPV) was...
Abstract In response to the COVID-19 pandemic, lateral flow assays (LFAs) for detection of SARS-CoV-2 antigen have been proposed as a complementary option more costly and time consuming reverse-transcriptase polymerase chain reaction (RT-PCR). We assessed five commercially available detecting LFAs (ASSUT EUROPE (Rome, Italy), Besthree (Taizhou, China), Encode (Zhuhai, Fortress (Antrim UK), Hughes Medical (Buckinghamshire, using samples collected from hospitalised individuals with compared...
Background: The scale of the 2022 global monkeypox outbreak has been unprecedented. In under six-months, non-endemic countries have reported over 67,000 cases a disease that had previously rare outside Africa. Mortality as but hospitalisation relatively common. We aimed to describe clinical and laboratory characteristics outcomes individuals hospitalised with associated complications, including tecovirimat recipients. Methods: Sixteen hospitals from Specialist High Consequence Infectious...
Reports of domestic abuse (DA) and sexual violence (SV) continue to rise across the UK, health services are well situated offer a safe setting for disclosure.We performed retrospective analysis all safeguarding proformas completed between April September 2019 three clinics in London.158 patients reported current and/or historical DA SV during collection period. 70% cohort identified as female, 28% male 2% transgender. 25% gay men. Black Asian attendees were disproportionately represented...
Switching from oral antiretroviral treatment to intramuscular (IM) cabotegravir (CAB) + rilpivirine (RPV) has an optional lead-in ensure tolerability. The British HIV Association guidelines advise against directly switching (ART) combinations containing strong/moderate cytochrome inducers like efavirenz (EFV) IM CAB RPV. EFV a prolonged elimination half-life, leading residual induction of UGT1A1 and CYP3A4 after discontinuation. These enzymes are responsible for RPV metabolism their might...
Linked article: V. Schwierzeck, in screening programmes. J Eur Acad Dermatol Venereol 2020; 34: e225–e226. https://doi.org/10.1111/jdv.16196 .
<title>Abstract</title> Severe Acute Respriatory Syndrome coronavirus-2 (SARS-CoV-2) remains a considerable risk to high populations, including older adults. The humoral immune response dynamics infection and/or immunisation in adults unclear. This protocol decribes the serological methods employed Sars-Cov-2 Antibody oLder PEopLe (SCALPEL) study which aims evaulate response, taking into account symptomatic and asymptomatic through regular weekly PCR testing supported by SARS-CoV-2...
Purpose People in prison face a disproportionate risk of sexually transmitted infections (STIs), but there is paucity evidence on trends STIs prisons England. This study aims to describe chlamydia test-positivity and syphilis prevalence by using two different methodologies settings. Design/methodology/approach used routinely collected surveillance data reported all primary diagnostic laboratories England from 2018 2022 identify tests undertaken prisons. Separately, this pilot serology four A...
Monoclonal antibody therapy has been approved for prophylaxis and treatment of severe COVID-19 infection. Greatest benefit appears limited to those yet mount an effective immune response from natural infection or vaccination, but concern exists around ability make timely assessment status community-based patients where laboratory-based serodiagnostics predominate. Participants were invited undergo paired (Abbott Architect SARS-CoV-2 IgG Quant II chemiluminescent microparticle immunoassay)...
<h3>Introduction</h3> People in prison are among the most marginalised society and experience significant health inequalities including poorer sexual than general population. There is a lack of national data on diagnoses sexually transmitted bacterial infections (STIs) people prison. <h3>Method</h3> Data all chlamydia tests performed by publicly commissioned laboratories England from 2017–2021 were obtained CTAD Chlamydia Surveillance System. To identify testing prisons, postcodes reported...
<h3>Introduction</h3> In 2023, BASHH released a report of apparent permethrin resistant scabies in England. We sought to evaluate whether permethrin-resistant had been reported our own service. <h3>Methods</h3> Electronic records were searched for diagnostic codes and ivermectin prescriptions. Treatment failure was defined as: i) Pruritus greater than one week following the second application topical scabicide ii) New burrows on clinical examination iii) Ongoing transmission completion...
<h3>Introduction</h3> The Mpox epidemic placed unprecedented strain on sexual health services: 9% of patients locally required hospitalisation, and the remainder a daily welfare check by telephone. Remote monitoring systems (RMS) offer effective management within their own homes, affording an opportunity for Mpox. <h3>Methods</h3> An existing RMS, in operation our hospital network, was repurposed to facilitate management. training provided RMS nursing team. A bespoke module developed Luscii...
<h3>Introduction</h3> Part of the UKHSA strategy for Mpox control focusses on vaccination. We describe roll-out vaccination within a large London sexual health service (SHS). <h3>Methods</h3> In initial phase, individuals at high-risk acquisition (defined by risk factors including recent STI, PrEP use, GBMSM) were invited SMS to attend scheduled vaccine clinics delivered SHS. Subsequently, staff from Trust's Flu/COVID seconded support delivery outside second we moved routine opportunistic...