Kazuya Furusawa

ORCID: 0000-0002-4465-3711
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About
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Research Areas
  • 3D Printing in Biomedical Research
  • Bone Tissue Engineering Materials
  • DNA and Nucleic Acid Chemistry
  • Collagen: Extraction and Characterization
  • Hydrogels: synthesis, properties, applications
  • Proteins in Food Systems
  • Electrospun Nanofibers in Biomedical Applications
  • Cellular Mechanics and Interactions
  • Tissue Engineering and Regenerative Medicine
  • Chemical Synthesis and Analysis
  • Bone health and osteoporosis research
  • Surfactants and Colloidal Systems
  • Polysaccharides Composition and Applications
  • Advanced biosensing and bioanalysis techniques
  • Dental Implant Techniques and Outcomes
  • Synthesis and characterization of novel inorganic/organometallic compounds
  • Micro and Nano Robotics
  • Advanced Materials and Mechanics
  • RNA and protein synthesis mechanisms
  • Supramolecular Self-Assembly in Materials
  • Pluripotent Stem Cells Research
  • Liquid Crystal Research Advancements
  • Ferrocene Chemistry and Applications
  • Organophosphorus compounds synthesis
  • Periodontal Regeneration and Treatments

Fukui University of Technology
2020-2024

Nagoya University
2023

Hokkaido University
2010-2020

Meijo University
2016

Gunma University
1990-2011

Kiryu University
2011

Tokyo Institute of Technology
1993-2010

Riso Kagaku (Japan)
1997

Public Works Research Institute
1985-1991

University College London
1927

Abstract Cyborg insects have been proposed for applications such as urban search and rescue. Body-mounted energy-harvesting devices are critical expanding the range of activity functionality cyborg insects. However, their power outputs limited to less than 1 mW, which is considerably lower those required wireless locomotion control. The area load energy harvesting device impair mobility tiny robots. Here, we describe integration an ultrasoft organic solar cell module on that preserves motion...

10.1038/s41528-022-00207-2 article EN cc-by npj Flexible Electronics 2022-09-05

It was more than 50 years ago that an appearance of birefringence in alginate gels prepared under cation flow reported for the first time, however, anisotropic structure gel has not been studied detail. In present study, Ca-alginate were within dialysis tubing a high Ca2+-concentration external bath, and optical small-angle X-ray scattering (SAXS) measurements performed to characterize gel. The observations with crossed polarizers circular revealed molecular orientation perpendicular...

10.1021/bm200223p article EN Biomacromolecules 2011-04-19

Bone tissues possess excellent mechanical properties such as compatibility between strength and flexibility load bearing owing to the hybridization of organic/inorganic matters with anisotropic structure. To synthetically mimic an structure natural hybrid materials, we carried out hydroxyapatite (HAp) mineralization in stretched tough double network (DN) hydrogels. Anisotropic HAp took place hydrogels, revealed by high brightness synchrotron X-ray scattering transmission electron microscopic...

10.1021/acsnano.7b04942 article EN ACS Nano 2017-10-27

The substrate specificities of dynein, kinesin, and myosin turnover activity cytoskeletal filament-driven translocation were examined using 15 ATP analogues. dyneins more selective in their utilization than bovine brain kinesin or muscle heavy meromyosin, even different types dyneins, such as 14S 22S dynein from Tetrahymena cilia the beta-heavy chain-containing particle outer-arm sea urchin flagella, could be distinguished by specificities. Although meromyosin both exhibited broad...

10.1083/jcb.112.6.1189 article EN The Journal of Cell Biology 1991-03-15

We have found that dialysis of 5 mg/mL collagen solution into the phosphate with a pH 7.1 and an ionic strength 151 mM [corrected] at 25 °C results in gel birefringence tubular pores aligned parallel to growth direction gel. The time course averaged diameter during anisotropic gelation was expressed by power law exponent 1/3, suggesting formation is attributed spinodal decomposition-like phase separation. Small angle light scattering patterns high resolution confocal laser scanning...

10.1021/bm200869p article EN Biomacromolecules 2011-11-22

Substrate physical properties are essential for many physiological events such as embryonic development and 3D tissue formation. Physical of the extracellular matrix viscoelasticity geometrical constraints understood factors that affect cell behaviour. In this study, we focused on relationship between epithelial morphogenesis substrate viscosity. We observed Madin-Darby Canine Kidney (MDCK) cells formed structures a viscous (Matrigel). The appear tulip hat. then changed viscosity by genipin...

10.1038/srep14208 article EN cc-by Scientific Reports 2015-09-16

In order to obtain a gelatin hydrogel crosslinked by reagent-free method, gamma-ray and electron beam radiation was applied porcine, bovine fish gels the products were characterized measuring gel fraction, swelling ratio enzymatic degradability. On increasing dose, fraction increased both degradability decreased. The transition temperature from sol of containing more than 5% mammal gelatins up 90 degrees C when or irradiated 10 kGy. results show that degree crosslinking hydrogels increases...

10.1163/156856203322553437 article EN Journal of Biomaterials Science Polymer Edition 2003-01-01

DNA liquid crystalline gel (LCG) has been newly prepared by a dialysis of concentrated solutions into metal cation solutions. The condition for forming LCG is examined means the insolubilization reaction. shrinking ratio and thickness layer, delta, diameter tube, d0, do not depend on d0. adsorption one carcinogenic agents, acridine orange demonstrated. From experimental results, mechanism DNALCG discussed.

10.1021/la061412+ article EN Langmuir 2006-12-09

Measurements have been made of the hydrogen ion concentration muscles various marine animals immediately after death and 20–24 hours after. The results obtained are same order as those previously found for frog cat.

10.1017/s0025315400058392 article EN Journal of the Marine Biological Association of the United Kingdom 1927-03-01

DNA liquid crystalline gel (LCG) films have been prepared by immersing aqueous borate solutions sandwiched between two circular glass plates into cobalt chloride solutions. The time courses of the thickness, weight fractions and cations, birefringence turbidity film consisted outer LCG inner amorphous or solution measured. To clarify mechanism process forming LCG, theory based on nonequilibrium thermodynamics with "moving boundary picture" [Langmuir 2005, 21, 8155-8160] was modified, results...

10.1021/jp076135+ article EN The Journal of Physical Chemistry B 2007-11-30

Abstract Cell-containing collagen gels are one of the materials employed in tissue engineering and drug testing. A gel is a useful three-dimensional (3D) scaffold that improves various cell functions compared to traditional two-dimensional plastic substrates. However, owing poor nutrient availability, cells not viable thick gels. Perfusion an effective method for supplying nutrients gel. In this study, we maintained hepatocytes embedded 3D using simple pump-free perfusion culture system with...

10.1038/s41598-022-24423-y article EN cc-by Scientific Reports 2022-11-24

Introduction of epithelial lumen-like structures such as blood and lymphatic vessels, well renal tubules, is a prerequisite for successful construction function artificially engineered giant tissues. Here, we demonstrate methodology various by using multichannel collagen gels (MCCGs). MCCGs were prepared used template scaffolds constructing lumen in controlled fashion. The effect NaCl concentration on the structure was investigated confocal laser scanning microscopy along with fluorescent...

10.1021/acsbiomaterials.5b00003 article EN publisher-specific-oa ACS Biomaterials Science & Engineering 2015-05-25

Abstract To quantify chiral shape, a tensor describing the particle shape has been proposed. This tensor, named (S‐tensor), is an analog of hydrodynamic that relates rotational and translational motions particles in liquid. The determinant S‐tensor, chirality measure density (CMD), was calculated for tetrahedrons octahedrons. It found CMD opposite sign when mirror images are to each other vanishes they achiral. Therefore, good distinguish images. interaction between discussed terms CMD.

10.1002/chir.23633 article EN Chirality 2024-01-14

To investigate the effects of pH on structure and properties DNA anisotropic gels their growth process, we have observed morphology gel films prepared from solutions with various initial pH, measured dependences shrinking ratio, birefringence, relaxation modulus as well time courses front pH-change lines. The high inhomogeneous macroscopic structure, large optical anisotropy whereas those low homogeneous small anisotropy. difference at different is attributed to in interaction between...

10.1021/jp102981a article EN The Journal of Physical Chemistry B 2010-10-14

Adsorption behaviors of acridine orange (AO) and biphenyl (BP) to DNA liquid crystalline gel (LCG) beads in aqueous dispersing solution have been studied theoretically experimentally. A theoretical consideration based on nonequilibrium thermodynamics predicted that the time course adsorption process is expressed with a scaled equation, number adsorbed carcinogen molecules ñ square root immersion t̃, ∝ at early stage, whereas it power law function 1 − (t̃e t̃)3/2 for ñ0 > an exponential...

10.1021/la701379q article EN Langmuir 2007-08-21

Alginate gels formed by diffusion of calcium ions into solutions sodium alginate were found to exhibit optical anisotropy depending on preparation conditions. When observed under crossed nicols, the anisotropic showed a birefringence pattern which is characteristic radial orientation polymer chains. Calcium prepared from different concentrations and ion, conditions for formation determined. The gel-formation process was measured monitoring development birefringent layer compared with model...

10.1007/s12573-009-0004-1 article EN Journal of Biorheology 2009-05-13

Mimicking the complicated anisotropic structures of a native tissue is extremely important in engineering. In previous study, we developed an collagen gel scaffold (ACGS) having hierarchical structure and properties gradient. this our objective was to see how cells remodel scaffolds through cells-ACGS interaction. For purpose, cultured osteoblastic on ACGS, which regarded as model system for cells-extracellular matrix (cell-ECM) Changes ACGS-cell composites by cell-ECM interactions...

10.1021/am303254e article EN ACS Applied Materials & Interfaces 2013-06-11
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