A5019465400- Soil Carbon and Nitrogen Dynamics
- Microbial Community Ecology and Physiology
- Wastewater Treatment and Nitrogen Removal
- Peatlands and Wetlands Ecology
- Cancer Immunotherapy and Biomarkers
- Genomics and Phylogenetic Studies
- SARS-CoV-2 and COVID-19 Research
- Immunotherapy and Immune Responses
- Microbial Fuel Cells and Bioremediation
- Iron oxide chemistry and applications
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- vaccines and immunoinformatics approaches
- Soil and Water Nutrient Dynamics
- Animal Virus Infections Studies
- Ammonia Synthesis and Nitrogen Reduction
- Chemical Reactions and Isotopes
- Cancer Genomics and Diagnostics
- Polyamine Metabolism and Applications
- Molecular Biology Techniques and Applications
- Biotin and Related Studies
- Radioactive element chemistry and processing
- Dermatology and Skin Diseases
- Soil and Unsaturated Flow
- Viral gastroenteritis research and epidemiology
CeGaT (Germany)
2020-2024
University of Tübingen
2014-2018
Biochar influences soil fertility, N2O emissions, and atmospheric CO2 budgets, because of its quinone aromatic structures, it is redox-active. Here we demonstrate that biochar concentrations 5 10 g L–1 stimulate both the rate extent microbial reduction Fe(III) oxyhydroxide mineral ferrihydrite (15 mM) by Shewanella oneidensis MR-1, while lower (0.5 1 L–1) have a negative effect on reduction. Control experiments showed particles not biochar-derived water-soluble organic compounds are...
Amending soil with biochar (pyrolized biomass) is suggested as a globally applicable approach to address climate change and degradation by carbon sequestration, reducing soil-borne greenhouse-gas emissions increasing nutrient retention. Biochar was shown promote plant growth, especially when combined nutrient-rich organic matter, e.g., co-composted biochar. Plant growth promotion explained slow release of nutrients, although mechanistic understanding storage in missing. Here we identify...
Nitrous oxide (N2O) is a potent greenhouse gas that produced during microbial nitrogen transformation processes such as nitrification and denitrification. Soils represent the largest sources of N2O emissions with fertilizer application being main driver rising atmospheric concentrations. Soil biochar amendment has been proposed promising tool to mitigate from soils. However, underlying cause emission suppression in biochar-amended soils are still poorly understood. We set up microcosm...
Abstract The application of biochar as a soil amendment to improve fertility has been suggested tool reduce soil‐borne CO 2 and non‐ greenhouse gas emissions, especially nitrous oxide (N O). Both laboratory field trials have demonstrated N O emission reduction by amendment, but the long‐term effect (>1 year) questioned. Here, we present results combined microcosm study using powdered beech wood from slow pyrolysis. experiment showed that both emissions were still effectively reduced in...
Summary Microaerophilic, phototrophic and nitrate‐reducing Fe(II)‐oxidizers co‐exist in coastal marine littoral freshwater sediments. However, the situ abundance, distribution diversity of metabolically active remained largely unexplored. Here, we characterized microbial community composition at oxic‐anoxic interface (Lake Constance, Germany) sediments (Kalø Vig Norsminde Fjord, Denmark) using DNA‐/RNA‐based next‐generation 16S rRNA (gene) amplicon sequencing. All three physiological groups...
Microbial nitrogen transformation processes such as denitrification represent major sources of the potent greenhouse gas nitrous oxide (N2O). Soil biochar amendment has been shown to significantly decrease N2O emissions in various soils. However, effect on structure and function microbial communities that actively perform redox transformations not studied detail yet. To analyse community composition denitrifying N2O-reducing communities, we collected RNA samples at different time points from...
Current treatment outcome of patients with glioblastoma (GBM) remains poor. Following standard therapy, recurrence is universal limited survival. Tumors from 173 GBM are analysed for somatic mutations to generate a personalized peptide vaccine targeting tumor-specific neoantigens. All were treated within the scope an individual healing attempt. Among all vaccinated patients, including 70 prior progression (primary) and 103 after (recurrent), median overall survival first diagnosis 31.9...
Abstract Gaining detailed insights into the role of host immune responses in viral clearance is critical for understanding COVID-19 pathogenesis and future treatment strategies. Although studies analyzing humoral against SARS-CoV-2 were available rather early during pandemic, cellular immunity came focus investigations just recently. For present work, we have adapted a protocol designed detection rare neoantigen-specific memory T cells cancer patients studying SARS-CoV-2. Both CD4+ CD8+...
Trace amines (TA) are endogenously produced in mammals, have a low concentration the central nervous system (CNS), but trigger variety of neurological effects and intervene host cell communication. It emerged that neurotransmitters TA also by microbiota. As it has been shown contribute to wound healing, we examined skin microbiome probands using shotgun metagenomics. The phyla Actinobacteria, Proteobacteria, Firmicutes, Bacteroidetes were predominant. Since SadA is highly promiscuous...
Localized prostate cancer is curable, but metastatic castration sensitive has a low 5-year survival rate, while broad treatment options are lacking. Here we present an mCSPC patient under remission receiving individualized neoantigen-derived peptide vaccination as recurrence prophylaxis in the setting of individual attempt. The was initially analyzed for somatic tumor mutations and then consecutively treated with two different vaccines over period 33 months. first vaccine contained predicted...
Breast cancer is a tumor entity that one of the leading causes mortality among women worldwide. Although numerous treatment options are available, current explorations personalized vaccines have shown potential as promising new to prevent recurrence cancer. Here we present small proof concept study using prophylactic peptide vaccination approach in four female breast patients who achieved remission after standard treatment. The were initially analyzed for somatic mutations and then treated...
Next-generation sequencing (NGS)-based comprehensive tumor profiling from liquid biopsy samples can significantly improve diagnosis and monitoring of tumors when high-quality tissue material is difficult to obtain. In addition, it offers the potential capture entire complexity tumor, which particularly important for highly heterogeneous or metastatic tumors. Here we report findings an analytical performance evaluation Illumina TruSight Oncology 500 ctDNA assay, a 523-gene NGS panel developed...
Abstract Gaining detailed insights into the role of host immune responses in viral clearance is critical for understanding COVID-19 pathogenesis and future treatment strategies. While studies analyzing humoral against SARS-CoV-2 were available rather early during pandemic, cellular immunity came focus investigations just recently. For present work, we have adapted a protocol, designed detection rare neoantigen-specific Memory T cells cancer patients studying SARS-CoV-2. Both, CD4+ CD8+...