A5010872139- Glioma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- vaccines and immunoinformatics approaches
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer, Stress, Anesthesia, and Immune Response
- Heat shock proteins research
- Cancer Research and Treatments
- Photoacoustic and Ultrasonic Imaging
- Neurological Disease Mechanisms and Treatments
- Energy Harvesting in Wireless Networks
- ATP Synthase and ATPases Research
- Neuroscience and Neuropharmacology Research
- Cancer Mechanisms and Therapy
- Neurogenetic and Muscular Disorders Research
- Congenital Anomalies and Fetal Surgery
- Connexins and lens biology
- Cancer Genomics and Diagnostics
- Extracellular vesicles in disease
- Sarcoma Diagnosis and Treatment
- Studies on Chitinases and Chitosanases
- Brain Metastases and Treatment
- Medicinal Plant Pharmacodynamics Research
- CAR-T cell therapy research
- Ubiquitin and proteasome pathways
Praxis für Humangenetik Tübingen
2022-2024
German Cancer Research Center
2018-2021
Heidelberg University
2018-2021
Ruhr University Bochum
2016-2019
DKFZ-ZMBH Alliance
2018
Abstract Promising results from recent clinical trials on the approved antisense oligonucleotide nusinersen in pediatric patients with 5q‐linked spinal muscular atrophy (SMA) still have to be confirmed adult but are hindered by a lack of sensitive biomarkers that indicate an early therapeutic response. Changes overall neurochemical composition cerebrospinal fluid (CSF) under therapy may yield additive diagnostic and predictive information. With this prospective proof‐of‐concept feasibility...
Current treatment outcome of patients with glioblastoma (GBM) remains poor. Following standard therapy, recurrence is universal limited survival. Tumors from 173 GBM are analysed for somatic mutations to generate a personalized peptide vaccine targeting tumor-specific neoantigens. All were treated within the scope an individual healing attempt. Among all vaccinated patients, including 70 prior progression (primary) and 103 after (recurrent), median overall survival first diagnosis 31.9...
Abstract Recent technological advances in molecular diagnostics through liquid biopsies hold the promise to repetitively monitor tumor evolution and treatment response of brain malignancies without need invasive surgical tissue accrual. Here, we implemented a mass spectrometry‐based protein analysis pipeline which identified hundreds proteins 251 cerebrospinal fluid (CSF) samples from patients with four types (glioblastoma, lymphoma, metastasis, leptomeningeal disease [LMD]) healthy...
A hallmark of glioblastoma multiforme (GBM) is neoangiogenesis, mediated by the overexpression vascular endothelial growth factor (VEGF). Anti-VEGF antibodies, like bevacizumab, prolong progression-free survival in GBM, however, this treatment has been reported to be associated with a decline neurocognitive function. Therefore, study focused on effects bevacizumab neuronal function and plasticity. We analyzed membrane properties synaptic plasticity rat hippocampal slices, as well spine...
Vascular endothelial growth factor (VEGF) is a hallmark of glioblastoma multiforme (GBM) and plays an important role in brain development function. Recently, it has been reported that treatment GBM patients with bevacizumab, anti-VEGF antibody, may cause decline neurocognitive function compromise quality life. Therefore, we investigated the effects VEGF bevacizumab on morphology survival neurons glial cells.Dissociated cortical hippocampal cell cultures juvenile rats were treated VEGF, +...
Localized prostate cancer is curable, but metastatic castration sensitive has a low 5-year survival rate, while broad treatment options are lacking. Here we present an mCSPC patient under remission receiving individualized neoantigen-derived peptide vaccination as recurrence prophylaxis in the setting of individual attempt. The was initially analyzed for somatic tumor mutations and then consecutively treated with two different vaccines over period 33 months. first vaccine contained predicted...
Breast cancer is a tumor entity that one of the leading causes mortality among women worldwide. Although numerous treatment options are available, current explorations personalized vaccines have shown potential as promising new to prevent recurrence cancer. Here we present small proof concept study using prophylactic peptide vaccination approach in four female breast patients who achieved remission after standard treatment. The were initially analyzed for somatic mutations and then treated...
Glioblastoma multiforme (GBM) is a highly aggressive glial brain tumor with an unfavorable prognosis despite all current therapies including surgery, radiation and chemotherapy. One characteristic of this strong synthesis vascular endothelial growth factor (VEGF), angiogenesis factor, followed by pronounced vascularization. VEGF became target in the treatment GBM, for example bevacizumab or tyrosine kinase inhibitor axitinib, which blocks receptors. To improve patients' prognosis, new...
Methadone is a well-known analgesic used in substitution therapy. In addition, methadone has been recently linked to cancer as it increases apoptosis and caspases activation glioma cell lines treated with doxorubicin inhibits tumor growth vivo. Although its effect on still under debate, since pro- anti-tumoral effects have observed data supporting efficacy beyond casuistic reports are missing, widely by glioblastoma patients the assumption that enhances of alkylating chemotherapy. Therefore,...
Abstract Current treatment outcome of patients with glioblastoma (GBM) remains poor. Following standard therapy, recurrence is universal limited survival. GBM tumors from 173 were analyzed for somatic mutations to generate a personalized peptide vaccine targeting tumor-specific neoepitopes. In agreement their treating physician, added as an individual healing attempt. Patients monitored October 2015 until August 2023. We retrospectively evaluated clinical courses and the results immune...
Abstract BACKGROUND Glioblastoma multiforme (GBM) is the most common and malignant primary brain tumor. Despite of current SoC, patients have a poor prognosis with median OS about 14-17 months.Method, RESULTS We report retrospectively analyzed data from 203 GBM (IDH wildtype) who added PTCV derived patient individual tumor mutations to their treatment regimen in setting attempts (ITA) Germany. Data were re. vaccine induced T cell responses safety acc. CTCAE terminology version 5.0. Subsets...