A5000407487- Hippo pathway signaling and YAP/TAZ
- Cancer-related Molecular Pathways
- Cancer Genomics and Diagnostics
- Caveolin-1 and cellular processes
- Evolutionary Psychology and Human Behavior
- Obsessive-Compulsive Spectrum Disorders
- Fibroblast Growth Factor Research
- Body Image and Dysmorphia Studies
- Lipid metabolism and biosynthesis
- Lipid metabolism and disorders
- Epigenetics and DNA Methylation
- Cancer, Lipids, and Metabolism
- Wnt/β-catenin signaling in development and cancer
- Connexins and lens biology
- Kruppel-like factors research
- Heat shock proteins research
- Colorectal Cancer Treatments and Studies
Weizmann Institute of Science
2016-2023
Tel Aviv University
2013
The Hippo signaling pathway is a major regulator of organ size. In the liver, deregulation promotes hyperplasia and hepatocellular carcinoma primarily through hyperactivation its downstream effector, YAP. LATS2 tumor suppressor core member pathway. A screen for LATS2-interacting proteins in liver-derived cells identified transcription factor SREBP2, master cholesterol homeostasis. down-regulation caused SREBP activation accumulation excessive cholesterol. Likewise, mice harboring...
The TP53 gene is mutated in approximately 60% of all colorectal cancer (CRC) cases. Over 20% TP53-mutated CRC tumors carry missense mutations at position R175 or R273. Here we report that harboring R273 are more prone to progress metastatic disease, with decreased survival, than those mutations. We identify a distinct transcriptional signature orchestrated by p53R273H, implicating activation oncogenic signaling pathways and predicting worse outcome. These features shared also the hotspot...
Deregulated activity of LArge Tumor Suppressor (LATS) tumor suppressors has broad implications on cellular and tissue homeostasis. We examined the consequences down-regulation either LATS1 or LATS2 in breast cancer. Consistent with their proposed suppressive roles, expression both paralogs was significantly down-regulated human cancer, loss paralog accelerated mammary tumorigenesis mice. However, each had a distinct impact Thus, depletion luminal B tumors resulted metabolic rewiring,...
Missense mutations in the p53 tumor suppressor abound human cancer. Common (“hotspot”) endow mutant (mutp53) proteins with oncogenic gain of function (GOF), including enhanced cell migration and invasiveness, favoring cancer progression. GOF is usually attributed to transcriptional effects mutp53. To elucidate transcription-independent mutp53, we characterized protein interactome p53R273H cells derived from pancreatic ductal adenocarcinoma (PDAC), where most frequent mutant. We now report...
The core Hippo pathway module consists of a tumour-suppressive kinase cascade that inhibits the transcriptional coactivators Yes-associated protein (YAP) and WW domain-containing transcription regulator 1 (WWTR1; also known as TAZ). When is downregulated, often occurs in breast cancer, YAP/TAZ activity induced. To elaborate roles TAZ triple-negative cancer (TNBC), we depleted Taz murine TNBC 4T1 cells, using either CRISPR/Cas9 or small hairpin RNA (shRNA). TAZ-depleted cells their controls,...
Objective Resolving the entangled nosological dilemma of whether obsessive-compulsive disorder (OCD) with and without schizophrenia (schizo-OCD OCD, respectively) are two independent entities or schizo-OCD is a combined product its parent disorders. Methods Studying motor activity in OCD patients. Performance patients was compared performance same task by matching control individual. Results Behavior both differed from controls excessive repetition addition acts, thus validating an identical...
Abstract Deregulated activity of the LATS tumor suppressors has broad implications on cellular and tissue homeostasis. We examined consequences downregulation either LATS1 or LATS2 in breast cancer. Consistent with their proposed tumor-suppressive roles, expression both paralogs is significantly downregulated human cancer, loss paralog accelerated mammary tumorigenesis mice. However, each had a distinct impact depletion luminal B tumors resulted metabolic rewiring, increased glycolysis...