A5021839735- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Sinusitis and nasal conditions
- Olfactory and Sensory Function Studies
- Dermatology and Skin Diseases
- Biochemical Analysis and Sensing Techniques
- Neuroscience and Neuropharmacology Research
- IL-33, ST2, and ILC Pathways
- Nasal Surgery and Airway Studies
- Cancer-related gene regulation
- Stress Responses and Cortisol
- Epigenetics and DNA Methylation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Global Maternal and Child Health
- Infectious Diseases and Mycology
- Hearing, Cochlea, Tinnitus, Genetics
- RNA Research and Splicing
- Oral and Maxillofacial Pathology
- Inflammasome and immune disorders
- Neurogenesis and neuroplasticity mechanisms
- Vestibular and auditory disorders
- Otitis Media and Relapsing Polychondritis
- Ferroptosis and cancer prognosis
- Bioactive Natural Diterpenoids Research
- Memory and Neural Mechanisms
Wuhan University
2020-2025
Renmin Hospital of Wuhan University
2020-2025
Shandong Provincial Hospital
2020-2024
Shandong University
2024
First Affiliated Hospital of GuangXi Medical University
2019-2021
Guangxi Medical University
2019-2021
Chronic rhinosinusitis with nasal polyps (CRSwNP) is caused by prolonged inflammation of the paranasal sinus mucosa. The epithelial to mesenchymal transition (EMT) involved in occurrence and development CRSwNP. T-cell immunoglobulin domain mucin 4 (TIM-4) closely related chronic inflammation, but its mechanism CRSwNP poorly understood. In our study, we found that TIM-4 was increased sinonasal mucosa patients and, especially, macrophages. positively correlated α-SMA negatively E-cadherin CRS....
Introduction: Osthole, a naturally occurring coumarin derivative, has been isolated from the traditional Chinese medicinal herb Cnidium monnieri. This compound exhibits range of pharmacological properties, including anticancer, antioxidant, anti-inflammatory, and immunomodulatory effects. The objective this study was to investigate role osthole in tissue remodeling chronic rhinosinusitis with nasal polyp (CRSwNP). Methods: effects on (NP) formation were examined within mouse model NPs...
Background In recent decades, dramatic changes in modern environmental exposures and lifestyles have resulted a steep rise the prevalence of allergic diseases such as asthma, rhinitis, atopic dermatitis food allergies. Evidence is mounting that microbiota plays crucial role disorder development evolution. Therefore, better understanding within context urgently needed. This work aimed to comprehensively outline general characteristics, research hotspots, evolution routes, emerging trends this...
Chronic rhinosinusitis with nasal polyps (CRSwNP) can be classified into eosinophilic CRSwNP (eCRSwNP) and non-eosinophilic (non-eCRSwNP) by tissue biopsy, which is difficult to perform preoperatively. Clinical biomarkers have predictive value for the classification of CRSwNP. We aimed evaluate application artificial neural network (ANN) modeling in distinguishing different endotypes based on clinical biomarkers.Clinical parameters were collected from 109 patients, their ability was...
Allergic rhinitis (AR) and migraine are among the most common public health problems worldwide. Observational studies on correlation between AR have reported inconsistent results. This study aimed to investigate causal relationship of with its subtypes, including aura (MA) without (MO). Bidirectional two-sample Mendelian randomization (MR) analysis was performed publicly available summary-level statistics large genome-wide association estimate possible effects. The inverse variance-weighted...
Deciphering the immune characteristics within tumors and identifying signals related to prognostic factor are helpful for treatment management of tumor patients. However, systematic analysis signatures in head neck squamous cell carcinoma (HNSCC) remains largely unstudied.A total 718 immune-related genes were extracted from RNA sequencing data 519 HNSCC patients TCGA database, survival with integrated bioinformatics analyses was performed build final predictive prognosis model.The 178...
Allergic rhinitis (AR) is an inflammatory disorder of the nose caused by immunoglobulin E (IgE)-mediated immune response to allergens. Apart from typical symptoms sneezing, itching, rhinorrhea, and nasal congestion, behavioral complications were also reported be associated with progression AR, such as cognitive deficits, mood changes, memory decline, attention deficiency, poor school performance, anxiety, depression. Recent human studies have suggested that alterations in brain function...
Allergic rhinitis (AR) is a common otolaryngology disease and one of the clinical causes olfactory dysfunction (OD). The bulb serves as transfer station for information transmission, alleviating its neuroinflammation may be expected to improve AR-induced OD. Recent studies have suggested that dopamine D2 receptor acts key target in regulating immune functions neuroinflammatory reaction. However, effect on still unknown.
Abstract Objective This study aimed to assess the knowledge, attitude, and practice (KAP) of WeChat users towards health-related public accounts. Methods The included 567 participants who completed questionnaire. Pearson correlation analysis was used evaluate among 3 dimensions. Multivariate identified independent factors associated with KAP scores. Results mean scores for were 6.12 ± 2.29 (61.2% total), 55.83 7.33 (69.8% 14.07 3.72 (70.4% respectively. Significant positive correlations...
A disintegrin and metalloproteinase 8 (ADAM8) has been implicated in eosinophilic inflammation; however, its role chronic rhinosinusitis with nasal polyps (CRSwNP) remains to be elucidated. This study aimed investigate the predictive significance of ADAM8 levels secretions for endotypes disease control status CRSwNP.
The present study aimed to investigate whether microRNA (miR)‑31 exerted therapeutic potential in allergic rhinitis (AR) and explore its underlying mechanism. Firstly, the expression levels of miR‑31 were detected by reverse transcription‑quantitative PCR nasal mucosa patients mice. Subsequently, an ovalbumin (OVA)‑induced animal model AR was constructed. Allergic symptom score, histopathological characteristics, OVA‑specific immunoglobulin E (IgE) titers,...
<b><i>Background:</i></b> A hallmark of eosinophilic chronic rhinosinusitis with nasal polyps (eCRSwNP) is mucosal eosinophil-predominant inflammation. Nasal nitric oxide (nNO) a known biomarker inflammation in the upper airway. However, utility nNO measurement airway remains controversial. The present study aimed to compare use other clinical parameters prediagnose patients eCRSwNP from Central China. <b><i>Methods:</i></b> From June 2019...