A5081943212- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- HIV-related health complications and treatments
- Tuberculosis Research and Epidemiology
- SARS-CoV-2 and COVID-19 Research
- Pneumonia and Respiratory Infections
- Mosquito-borne diseases and control
- Bacterial Infections and Vaccines
- Viral Infections and Vectors
- Vaccine Coverage and Hesitancy
- Pneumocystis jirovecii pneumonia detection and treatment
- Influenza Virus Research Studies
- Vector-borne infectious diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- COVID-19 Impact on Reproduction
- Malaria Research and Control
- Virology and Viral Diseases
- Helminth infection and control
- Immunodeficiency and Autoimmune Disorders
- Parasites and Host Interactions
- Pharmaceutical studies and practices
- Parasite Biology and Host Interactions
- Parvovirus B19 Infection Studies
- demographic modeling and climate adaptation
Siriraj Hospital
2014-2024
Mahidol University
2014-2024
Pediatrics and Genetics
2022
Udayana University
2019
University of British Columbia
2010-2013
British Columbia Children's Hospital
2009-2013
University of Toronto
2011
Hospital for Sick Children
2011
SickKids Foundation
2011
Mahidol Oxford Tropical Medicine Research Unit
2004-2006
To maximize the potential of genomics in medicine, it is essential to establish databases genomic variants for ethno-geographic groups that can be used filtering and prioritizing candidate pathogenic variants. Populations with non-European ancestry are poorly represented among current variant databases. Here, we report first high-density survey Thai population, Reference Exome (T-REx) database. T-REx comprises exome sequencing data 1092 unrelated individuals. The targeted regions common four...
Introduction There are gaps in knowledge and experience of antiretroviral pre-exposure prophylaxis (PrEP) delivery adolescents. Methods This pilot study enrolled Thai adolescents 14–20 year-old without HIV who reported risk behaviour. All participants were offered daily tenofovir/emtricitabine (TDF-FTC) followed for 24 weeks. testing, renal function, bone density scan, sexually transmitted infection (STI) testing including syphilis serology urine molecular gonorrhoea C . trachomatis...
Understanding dengue virus infection in children and the kinetics of maternal neutralizing antibodies is essential for effective immunization endemic areas.Serum samples from 219 mother-child pairs 140 at 3, 6, 9, 12, 18, 24 months age Bangkok, Thailand, were tested serotype-specific antibodies. Febrile episodes recorded.Antibodies found 97% cord serum disappeared 27%, 80%, 95% by 12 months, respectively. Geometric mean titers (GMTs) to 4 serotypes decreased 5.4-15.5 6-month-old infants....
When a neurologic condition develops after vaccination of patient, the causal relationship is difficult to determine. We report an unusual case in which signs occurred previously healthy child both doses H1N1 2009 influenza vaccine, culminating bilateral optic neuritis and disseminated encephalomyelitis. A association more likely with repeated injury following vaccination.
Despite a decrease in infections caused by Bordetella pertussis due to COVID-19 pandemic, booster vaccination of pregnant women is still recommended protect newborns. Highly immunogenic vaccines containing genetically inactivated toxin (PT
Protease inhibitor (PI) may cause abnormal glucose metabolism, lipid and metabolic syndrome in HIV-infected adults but less well studied Asian adolescents. This cross-sectional study evaluated anthropometric factors, oral tolerance test, profiles of perinatally Thai adolescents who had received PI-based antiretroviral therapy for at least 6 months. Eighty were enrolled [median (IQR) age 16.7 (14.6-18.0) years, 42 males]. Metabolic syndrome, prediabetes, type 2 diabetes mellitus (T2DM) found...
From 1992 to 1997, 140 Thai children 4–15 years of age received an investigational live attenuated tetravalent dengue vaccine (LATDV). These were contacted 3–8 later in 2001 assess humoral immunity and investigate whether they subsequently at higher risk developing severe dengue. One hundred thirteen successfully participated this retrospective cohort study with two age- address-matched controls per vaccinee. The number vaccinated subjects neutralizing antibodies increased compared earlier,...
Objectives: To evaluate the carotid intima–media thickness (cIMT) in perinatally HIV-infected adolescents and factors associated with cardiovascular abnormalities. Designs: A cross-sectional study was conducted who had no known condition healthy controls. Methods: Transthoracic echocardiogram cIMT measurements were taken by pediatric cardiologists. Serum lipid profiles, high-sensitivity C-reactive protein N-terminal pro-brain natriuretic peptide measured. Results: Hundred 50 enrolled....
We assessed the prevalence of vitamin D deficiency among 101 perinatally HIV-infected Thai adolescents receiving antiretroviral therapy. Median age was 14.3 (interquartile range 13.0–15.7) years, and 90% had a HIV RNA <50 copies/mL. The median range) 25-hydroxyvitamin (25-OHD) level 24.8 (6.9–46.9) ng/mL; 25 (24.7%) (25-OHD <20 ng/mL) 47 (46.5%) insufficiency 20–30 ng/mL). Adolescents with significantly higher parathyroid hormone levels (54.9 vs. 40.2 pg/mL, P < 0.007). No associations...
BackgroundNon-nucleoside reverse transcriptase inhibitor (NNRTI)-based highly active antiretroviral therapy (HAART) has been the most affordable regimen for HIV-infected in developing countries. There are limited data comparing nevirapine (NVP) to efavirenz (EFV) children. This study aimed assess efficacy and tolerability of NVP-based regimens compared EFV-based children Thailand.MethodsThe medical records who had received NNRTI-based more than 6 months at Department Pediatrics, Siriraj...
Objective: To implement a standardized cause of death reporting and review process to systematically disaggregate causes HIV-related deaths in cohort Asian children adolescents. Design: Death-related data were retrospectively prospectively assessed longitudinal regional study. Methods: Children under routine HIV care at sites Cambodia, India, Indonesia, Malaysia, Thailand, Vietnam between 2008 2017 followed. Causes reported then independently centrally reviewed. Predictors compared using...
This open-labeled non-inferiority trial evaluated immunogenicity and reactogenicity of heterologous homologous COVID-19 vaccination schedules in pregnant Thai women. 18–45-year-old women with no history infection or a gestational age ≥12 weeks were randomized 1:1:1 into three two-dose primary series scheduled 4 apart: BNT162b2-BNT162b2 (Group 1), ChAdOx1-BNT162b2 2), CoronaVac-BNT162b2 3). Serum antibody responses, maternal cord blood levels at delivery, adverse events (AEs) following until...
Recombinant acellular pertussis (ap) vaccines containing genetically inactivated toxin (PTgen) and filamentous hemagglutinin (FHA) with or without tetanus (TT) diphtheria (DT) (Td) were found safe immunogenic in non-pregnant pregnant women. We report here maternal antibody transfer safety data mothers neonates. This is the follow up of a phase 2 trial 2019 among 400 women who randomly received one dose recombinant pertussis-only vaccine 1 µg PTgen FHA (ap1gen), Td combined ap1gen (Tdap1gen),...
Integrative mental health care in HIV patients is an important contributor to successful therapy. This a cross-sectional study youth and young adults who attend routine clinic at tertiary centre Bangkok. We recruited 100 130 living with evaluate the frequency of depression anxiety associated sociodemographic including sexual orientation health-related behaviours. Overall, about fifth participants had significant or anxiety. Interestingly, we found different factors HIV. Loss their father,...
Few data on drug-resistant (DR) tuberculosis (TB) in children are available Thailand.To evaluate the rate, clinical features and risk of DR-TB children.Observational prospective study conducted diagnosed with TB at a tertiary care centre Bangkok.Of 230 TB, median age was 6.5 years; 63% had identified adult source cases, only 7% received prior isoniazid treatment for latent tuberculous infection. Of 195 (85%) specimens submitted, 57 (25%) were positive using culture or polymerase chain...
Lipodystrophy (LD) was evaluated in 205 children receiving antiretroviral therapy by a single investigator: 51 (24.9%) had LD; 46 peripheral lipoatrophy, three central lipohypertrophy and two combined type. All cases of LD also facial lipoatrophy. Serial photographs were provided the families to confirm severity Forty-six (95.8%) with or LD, 75 (48.7%) without exposed stavudine (d4T) for median duration 45.9 versus 26.4 months (P = 0.005). In multivariate analysis, exposure d4T more than...
Paragonimiasis is a food-born zoonotic parasitosis caused by Paragonimus spp. Six cases of reemerging paragonimiasis within the Karan hill-tribe near Thai-Myanmar border were evaluated to review clinical manifestations, predisposing factors, and treatment regimens. All patients tested positive for eggs presented with an array symptoms, including chronic cough, hemoptysis, peripheral eosinophilia, thoracic radiograph abnormalities. fully recovered after 2- 5-day course 75 80 mg/kg/day...
AbstractThe pharmacokinetics of albendazole/albendazole sulphoxide and praziquantel were investigated in Thai children with Giardia infection. Twenty school-age randomly allocated to receive either a single oral dose albendazole (400 mg/child) or the same given concurrently (20 mg/kg). The concentrations plasma samples, collected at intervals first 24 h post-treatment, then quantified using HPLC ultra-violet detection. No significant pharmacokinetic interaction between was demonstrated. For...
Seroprevalence of dengue antibodies were determined in healthy children Bangkok. At 9, 12, and 18 months age 23%, 9%, 17% respectively had neutralizing against one or more serotypes. DEN1 was the most prevalent, followed by DEN3, DEN2, DEN4. Twelve serologic evidence infection. The nadir at 12 age. In highly endemic areas, vaccination could be needed an early