A5000348536- Respiratory viral infections research
- Pneumonia and Respiratory Infections
- Immunodeficiency and Autoimmune Disorders
- Tracheal and airway disorders
- IL-33, ST2, and ILC Pathways
- Congenital Diaphragmatic Hernia Studies
- Asthma and respiratory diseases
- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- Tuberculosis Research and Epidemiology
- Methemoglobinemia and Tumor Lysis Syndrome
- Platelet Disorders and Treatments
- Salivary Gland Tumors Diagnosis and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neonatal Health and Biochemistry
- Contact Dermatitis and Allergies
- Pneumocystis jirovecii pneumonia detection and treatment
- Heme Oxygenase-1 and Carbon Monoxide
- Anesthesia and Neurotoxicity Research
- Phonocardiography and Auscultation Techniques
- Diagnosis and treatment of tuberculosis
- Blood groups and transfusion
- PARP inhibition in cancer therapy
- Myasthenia Gravis and Thymoma
- Pediatric Pain Management Techniques
AZ Sint-Jan
2008-2025
KU Leuven
2006-2023
Universitair Ziekenhuis Leuven
2016
St. John Fisher College
2012
STAT6 (signal transducer and activator of transcription 6) is a factor that plays central role in the pathophysiology allergic inflammation. We have identified 16 patients from 10 families spanning three continents with profound phenotype early-life onset immune dysregulation, widespread treatment-resistant atopic dermatitis, hypereosinophilia esosinophilic gastrointestinal disease, asthma, elevated serum IgE, IgE-mediated food allergies, anaphylaxis. The cases were either sporadic (seven...
Objective We investigated the potential yield of incorporating fractional exhaled nitric oxide (FeNO) measurements in childhood allergic asthma management. Methods Ninety-nine children with persistent were included this multicentre, single-blind, randomized controlled trial. Treatment was based on Global Initiative for Asthma (GINA) guidelines. In FeNO group, management also guided by measurements. Health outcomes evaluated over a 52-week timeframe. Results Fewer exacerbations registered...
Abstract Background Type 1 regulatory T (Tr1) cells are critical players in maintaining peripheral tolerance, by producing high IL‐10 levels association with inducible T‐cell co‐stimulator (ICOS) expression. Whether these play a role naturally acquired baked egg tolerance is unknown. Objectives Evaluate frequencies of egg‐responsive Tr1 and Th2 egg‐allergic children that (BET) versus non‐egg‐allergic (NEA) children. Methods Peripheral blood mononuclear from 70 natural BET 15 NEA were...
Respiratory infections are major causes of morbidity and mortality, but determinants susceptibility poorly defined. We studied whether to what extent immunologic genetic factors associated with increased respiratory infections.We evaluated the prevalence IgA, IgM, IgG, IgG subclass deficiencies, impairment in antibody response against pneumococcal polysaccharides, G2m(n) allotypes, Fc gamma RIIa polymorphisms, partial C2 C4 deficiency, promoter polymorphisms MBL2, lymphocyte subset...
Measurement of postimmunization antibody response to pneumococcal capsular polysaccharide (caps-PS) is the standard method identify deficiency antipolysaccharide production. However, no standardized criteria have been defined for classification patients into responders or nonresponders caps-PS.We vaccinated 37 healthy children and 39 adults with Pneumovax measured anti-caps-PS 5 serotypes. We also antipneumococcal titers in 82 increased susceptibility airway infection. The ELISA was...
Abstract Aim: To evaluate the long‐term effect of montelukast on symptoms cough and wheeze following RSV bronchiolitis. Methods: Fifty eight patients (aged ≤ 24 months) hospitalized with a first episode bronchiolitis were enrolled in this double blind prospective randomized trial comparing (n = 31) vs placebo 27). Results: During 3‐month treatment period, there no statistical significant differences between two groups for symptom‐free days nights (48.5 [interquartile range 33.0.0–66.0] 57.0...
Over the last few years, studies have shown that majority of egg allergic children tolerate baked (e.g., cake), and consuming accelerates resolution allergy. However, prospective demonstrate step-wise reintroduction at home after developing tolerance. Although this could a positive impact on children's quality life nutrition. Additionally, research supporting theoretical concept heating in presence or absence wheat causes reduced allergenicity proteins is limited.To investigate clinically...
Thanks to its non-invasive nature and high-resolution imaging capabilities, magnetic resonance (MRI) is a valuable diagnostic tool for pediatric patients. However, the fear anxiety experienced by young children during MRI scans often result in suboptimal image quality need sedation/anesthesia. This study aimed evaluate effect of smartphone application called COSMO@home prepare reduce sedation or general anesthesia. The app was developed incorporating mini-games an engaging storyline learning...
Background We aimed to provide regional data on clinical symptoms, medical resource utilization (MRU), and risk factors for increased MRU in hospitalized respiratory syncytial virus (RSV)-infected Belgian pediatric population. Methods This prospective, multicenter study enrolled RSV (+) children (aged ≤5y) during the 2013–2015 seasons. was diagnosed within 24h of hospitalization. Disease severity patients assessed until discharge or up maximum six days using a Physical Examination Score...
A 12-year-old boy with chronic respiratory complaints, including cough, exercise intolerance, and persistent wheezing, was referred to our hospital because of symptoms under extensive asthma therapy. standard radiograph the chest detected very slight hyperinflation left lung increased translucency (Figure 1). Computed tomography revealed a polypoid mass distally in main bronchus density around 55 HU slightly decreased attenuation lung, probably due secondary air trapping 2). Bronchoscopy...
Undergoing an awake MRI-scan can be very stressful for young children and bears the risk that image quality is poor due to motion artefacts. Behavioral training by experienced trainer has shown success in preparing before a scan, however, this approach costly dependent. We have designed mobile app prepare upcoming at home. This was tested 52 four different hospitals. First data show parents appreciate much learning goals reached with digital application