Abstract Background With the implementation of multimodal analgesia regimens in fast-track surgery programmes, non-steroidal anti-inflammatory drugs (NSAIDs) are being prescribed routinely. However, doubts have been raised concerning safety NSAIDs terms anastomotic healing. Methods Data on patients who had undergone primary colorectal anastomosis at two teaching hospitals between January 2008 and December 2010 were analysed retrospectively. Exact use was recorded. Rates leakage compared...

The shortage of organ donors presents a major obstacle for adequate treatment patients with end-stage renal disease. Donation after cardiac death (DCD) has been shown to increase the number kidneys available transplantation. present article reports on first 25 years our experience DCD kidney transplantation.This observational cohort study included all transplantations recovered in procurement area from January 1, 1981 until December 31, 2005 (n=297). Patients were followed up earliest or...

The continuing shortage of kidneys for transplantation requires major efforts to expand the donor pool. Donation after cardiac death (DCD) increases number available kidneys, but it is unknown whether patients who receive a DCD kidney live longer than remain on dialysis and wait conventional from brain-dead (DBD). This observational cohort study included all 2575 were registered Dutch waiting list first transplant between January 1, 1999, December 31, 2004. From listing until earliest death,...

Increased understanding of the pathophysiology ischemic acute kidney injury in renal transplantation may lead to novel therapies that improve early graft function. Therefore, we studied microcirculation ischemically injured kidneys from donors after cardiac death (DCD) and living donor with minimal ischemia. During transplant surgery, peritubular capillaries were visualized by sidestream darkfield imaging. Despite a profound reduction creatinine clearance, total renovascular resistance DCD...

Kidney donation after cardiac death has been popularized over the last decade. The majority of these kidneys are from controlled donors. number organs for transplantation can be further increased by uncontrolled donors death. outcome compared to donor kidney is relatively unknown. We long-term (n = 128) and 208) procured in Maastricht region January 1, 1981 until 2008, transplanted Eurotransplant region. incidence primary nonfunction delayed graft function both high (22% vs. 21%, 61% 56%, p...

Organ donation after cardiac death increases the number of donor organs. In controlled donors, period between withdrawal life-sustaining treatment and arrest is one parameters used to assess whether organs are suitable for transplantation. The objective this study was identify characteristics that affect interval death.Prospective multicenter observational data.All potential donors in Netherlands May 2007 June 2009 were identified.None.Of 242 211 entered analysis, 76% them died within 60...

Non-heart-beating donor (NHBD) kidneys may substantially expand the pool, but many transplant centers are reluctant to use these because of relatively high incidence primary nonfunction (PNF). In heart-beating kidneys, intravascular fluid depletion during surgery is associated with delayed graft function (DGF). Therefore, we studied effect recipients' hemodynamic status on outcome 177 NHBD kidney transplantations. Independent statistically significant predictors PNF were average central...

Kidneys from old donors after cardiac death (DCD) may increase the donor pool but prognosis of these kidneys is unsatisfactory. To improve results, we retrospectively evaluated diagnostic utility published selection algorithms for kidneys. We studied all DCD kidney transplantations between January 1, 1994 and July 2005 at our institution (n = 199). Selection were in subset aged 60 years or older 52). For histological assessment biopsies, glomerulosclerosis, tubular atrophy, interstitial...

Donation after cardiac death (DCD) has shown to be a valuable extension of the donor pool despite higher percentage primary nonfunction (PNF). Limiting incidence PNF is vital importance. Renovascular resistance believed predict graft outcome; however literature inconsistent. Therefore, we studied whether renovascular associated with and this parameter should used discard kidneys. All transplanted DCD kidneys preserved by machine perfusion at our center between 1993 2007 were analyzed (n =...

Donation after cardiac death (DCD) increases the number of donor kidneys but is associated with more primary nonfunction (PNF) and delayed graft function (DGF). It has been suggested that biomarkers in preservation solution machine perfused may predict PNF, although evidence lacking.We analyzed diagnostic accuracy perfusate glutathione S-transferase, lactate dehydrogenase (LDH), heart-type fatty acid binding protein, redox-active iron, interleukin (IL)-18, neutrophil gelatinase-associated...

Abstract The in vivo assessment of renal damage after ischemia–reperfusion injury, such as sepsis, hypovolemic shock or transplantation, is a major challenge. This injury often results temporary permanent nonfunction. In order to improve the clinical outcome kidneys, novel therapies are currently being developed that limit injury. However, fully address their therapeutic potential, noninvasive imaging methods required which allow visualization different compartments and evaluation kidney...

Seroma formation is a common complication following mastectomy for invasive breast cancer. Mastectomy flap fixation achieved by reducing dead space volume using interrupted subcutaneous sutures. All patients undergoing due to cancer or ductal carcinoma in situ (DCIS) were eligible inclusion. From May 2012 March 2013, all two hospitals treated fixation. The skin flaps sutured on the pectoral muscle polyfilament absorbable data was retrospectively analysed and compared historical control group...

In Brief Objectives: To describe the results and complications of in situ preservation (ISP) kidneys from donors after cardiac death (DCD). Background: DCD are increasingly being used to expand pool donor kidneys. ISP reduces warm ischemic injury which is associated with donation. Methods: Insertion a double-balloon triple-lumen catheter allows selective perfusion abdominal aorta preserve situ. From January 2001 until August 2005, 133 procedures were initiated our procurement area. Results:...

In Brief Objective: To provide an integrated insight into the kinetics of tubular injury, inflammation, and oxidative stress after human kidney transplantation. Background: Tissue injury due to ischemia reperfusion is inevitable consequence Tubular epithelial play major roles in pathophysiology acute small animals, but it remains be established whether this paradigm holds true for Methods: Markers were compared between recipients kidneys from donors cardiac death (DCD; N = 8) with prolonged...

Snoeijs M G J, Boonstra L A, Buurman W Goldschmeding R, van Suylen R Heurn E & Peutz‐Kootstra C J (2010) Histopathology 56, 198–202 Histological assessment of pre‐transplant kidney biopsies is reproducible and representative Aims: examination renal biopsy specimens can be used to select grafts from older donors after cardiac death (DCD) with a satisfactory transplant outcome. The aim was determine whether such reproducibly scored between pathologists are the whole kidney. Methods...

Background Optimal duration of leg compression after venous ablation remains unclear. This randomised controlled trial evaluates 4 h compared to 72 compression. Methods Patients were or radiofrequency the great saphenous vein. Primary outcome was change in volume 14 days. Secondary outcomes postoperative pain, complications and time full recovery. Results wearing stockings for treatment had a 64 mL (95%CI: − 23 + 193) reduction volume, an increase 21 8.33–34.5) patients ( P = 0.12)....

Although acceptable outcomes have been reported in both non-heart-beating (NHB) and elderly donors individually, the large pool of NHB has not yet fully utilized. In 1994, we expanded our transplant protocol to include aged over 65 years this study compares clinical with regular transplantations. Up June 2005, 24 patients were transplanted at center kidneys from or more, whereas 176 received grafts conventional during same period. Grafts older associated inferior glomerular filtration rates...

Redox-active iron, catalyzing the generation of reactive oxygen species, has been implicated in experimental renal ischemia-reperfusion injury. However, clinical transplantation, it is unknown whether redox-active iron involved pathophysiology ischemic injury non-heart-beating (NHB) donor kidneys. We measured concentrations perfusate samples 231 deceased kidneys that were preserved by machine pulsatile perfusion at our institution between May 1998 and November 2002 using bleomycin detectable...

Currently available conduits for in situ reconstruction after excision of infected aortic grafts have significant limitations. The Omniflow II vascular prosthesis is a biosynthetic graft associated with low incidence infection that has succesfully been used the treatment infrainguinal bypass. We report on first use infection.A bifurcated bypass was created by spatulating and anastomosing two 8-mm tubular grafts. This three cases. After mean follow-up 2.2 years, no occlusion, degeneration, or...