A5103024701- Cytomegalovirus and herpesvirus research
- Ocular Diseases and Behçet’s Syndrome
- Ferroptosis and cancer prognosis
- Retinal Diseases and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Retinal Imaging and Analysis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Glaucoma and retinal disorders
- Cancer Immunotherapy and Biomarkers
- Fungal Infections and Studies
- Peptidase Inhibition and Analysis
- Cardiac electrophysiology and arrhythmias
- Neonatal Health and Biochemistry
- Pancreatic and Hepatic Oncology Research
- Extracellular vesicles in disease
- Retinoids in leukemia and cellular processes
- Galectins and Cancer Biology
- Ion channel regulation and function
- Morinda citrifolia extract uses
- Medicinal Plants and Neuroprotection
- Signaling Pathways in Disease
- Hippo pathway signaling and YAP/TAZ
- Autophagy in Disease and Therapy
Tongji University
2021-2024
Shanghai Tenth People's Hospital
2021-2024
Eastern Hepatobiliary Surgery Hospital
2019-2022
Second Military Medical University
2019-2022
Capital Medical University
2016-2020
Beijing Ditan Hospital
2012-2020
ShanghaiTech University
2020
Beijing Tongren Hospital
2019
Capital University
2019
Children's Hospital of Zhejiang University
2005-2006
The majority of hepatocellular carcinoma (HCC) cases are diagnosed at an advanced stage. Currently, there only a few therapeutic methods available for patients with HCC and extrahepatic metastasis (EHM). Systemic chemotherapy, such as FOLFOX4 (infusions fluorouracil, leucovorin, oxaliplatin), has been reported treating EHM, but its effectiveness is very poor. In this randomized, double-blind, placebo-controlled study, we aimed to assess the efficacy safety all-trans-retinoic acid (ATRA)...
The conserved Hippo pathway regulates organ size, tissue homeostasis, and tumorigenesis. Interferon regulatory factor 2 binding protein (IRF2BP2) was originally identified as a transcriptional corepressor. However, the association between IRF2BP2 remains largely unknown. In addition, biological function regulation mechanism of in liver cancer are poorly understood.In this study, we uncovered clinical significance suppressing hepatocellular carcinogenesis. We showed that IRF2BP2, direct...
Portal vein tumor thrombosis (PVTT), a severe complication of hepatocellular carcinoma (HCC), markedly influences patient prognosis by fostering hypercoagulable state. However, its molecular underpinnings remain largely unexplored. This study sheds light on the critical role KIT ligand (KITLG) in modulating expression collagen gene COL4A1 via STAT3-SMAD2 signaling pathway, thereby influencing platelet activation and PVTT development. Extensive analysis tissue samples, alongside vitro vivo...
Cuproptosis, as a novel copper-dependent and non-apoptotic form of cell death, is induced by aggregation lipoylated mitochondrial proteins the instability Fe-S cluster proteins. However, role cuproptosis-related long noncoding RNAs (CRLncRNAs) in hepatocellular carcinoma (HCC) has not been clearly elucidated. In this study, we identified characterized lncRNAs HCC. 343 HCC cases from The Cancer Genome Atlas (TCGA) with gene transcriptome data clinical were obtained for analysis after...
Purpose: To describe the 6-year incidence of early and late age-related macular degeneration (AMD) its associated factors in a representative large rural Chinese population. Methods: A population-based longitudinal study was conducted China from 2006 to 2007. In total, 6830 persons aged 30 years or older participated study. The follow-up performed between 2012 2013. modified Wisconsin Age-Related Maculopathy Grading System (WARMGS) protocol Blue Mountains Eye Study used as AMD grading...
A case of frosted branch angiitis in an AIDS patient with cytomegalovirus (CMV) retinitis is reported. The use PCR techniques for CMV DNA detection intraocular fluid was helpful this situation. appropriate therapy given promptly due to the timely diagnosis based on assay.
The current clinical classification of pancreatic ductal adenocarcinoma (PDAC) cannot well predict the patient's possible response to treatment plan, nor can it prognosis. We use gene expression patterns PDAC patients reveal heterogeneity tumor microenvironment cancer and analyze differences in prognosis immunotherapy different immune subtypes.Firstly, ICGC's PACA-AU profile data, combined with ssGSEA algorithm, enrichment microenvironment. Subsequently, spectral clustering algorithm was...
Background Immune checkpoint inhibitor (ICI), coupled with systemic chemotherapy, may enhance the clinical benefit of cancer by potentiating antitumor immunity, but its efficacy and safety are not clear in advanced intrahepatic cholangiocarcinoma (ICC). This study aims to assess camrelizumab plus gemcitabine oxaliplatin (GEMOX) for treatment ICC real world. Methods Advanced patients receiving at least one session GEMOX combination from March 2020 February 2022 two high-volume centers were...
Abstract Background: Chemotherapy is a common treatment for advanced hepatocellular carcinoma, but the effect not satisfactory. The study aimed to retrospectively evaluate effects of adding all-trans-retinoic acid (ATRA) infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) carcinoma (HCC). Methods: We extracted data patients with HCC who underwent systemic chemotherapy using FOLFOX4 or ATRA plus at Eastern Hepatobiliary Surgery Hospital, First Hospital Jilin University, Zhejiang...
Background Ganoderma lucidum is reportedly the best source of traditional natural bioactive constituents. triterpenoids (GTs) have been verified as an alternative adjuvant for treating leukemia, cancer, hepatitis and diabetes. One major triterpenoids, Resinacein S, has found to regulate lipid metabolism mitochondrial biogenesis. Nonalcoholic fatty liver disease (NAFLD) a common chronic that become public health problem. Given regulatory effects on we sought explore potential protective...
Hepatocellular carcinoma (HCC) with bile duct tumor thrombus (BDTT) is rare. The aim of this study to evaluate the long-term prognosis liver resection (LR) versus transcatheter arterial chemoembolization (TACE) in these patients. Data from HCC patients BDTT who underwent and TACE were analyzed respectively. Propensity score matching (PSM) analysis was performed A total 145 divided into two groups: LR group (n = 105) 40). median OS 8.0 months longer than that before PSM (21.0 vs. 13.0 months,...
As a member of the death-associated protein kinase (DAPK) family, STK17B plays an important role in regulation cellular apoptosis and has been considered as promising drug target for hepatocellular carcinoma. However, highly conserved ATP-binding site kinases represents challenge to design selective inhibitors specific DAPK isoform. In this study, molecular docking, multiple large-scale dynamics (MD) simulations, binding free energy calculations were performed decipher mechanism selectivity...
Purpose: To determine the value of polymerase chain reaction analysis aqueous humor specimens as a tool to diagnose cytomegalovirus retinitis in AIDS patients. Methods: In all, 63 patients were evaluated this study. They sorted into two diagnostic categories: eyes with active and without retinitis. The blood samples collected analyzed by reaction. Results: A total 49 had (77.8%) 14 inactive or normal fundus (22.2%). mean average was 39 years (range: 22–59). majority male (90.5%)....
Background: Neonatal respiratory distress syndrome (RDS), also known as hyaline membrane disease (HMD), occurs due to a deficiency of pulmonary surfactant (PS), leading rapid onset, fast progression, and poor prognosis the disease. Objectives: To analyze perinatal high-risk factors for RDS in late preterm infants. Methods: This was case-control study. One hundred thirty-eight infants admitted our hospital from January 2022 December 2023 were selected divided into observation group (n = 36)...