A5026886329- Cancer-related Molecular Pathways
- IL-33, ST2, and ILC Pathways
- Cutaneous lymphoproliferative disorders research
- Nonmelanoma Skin Cancer Studies
- Dermatology and Skin Diseases
- Geology and Paleoclimatology Research
- Climate change and permafrost
- Glioma Diagnosis and Treatment
- Urticaria and Related Conditions
- Asthma and respiratory diseases
- Peatlands and Wetlands Ecology
- Cancer Genomics and Diagnostics
Duke University
2001-2024
Abstract Prurigo nodularis (PN) is a chronic inflammatory skin disease that associated with variability in peripheral blood eosinophil levels and response to T-helper 2 targeted therapies (Th2). Our objective was determine whether circulating immune profiles respect type inflammation differ by race count. Plasma from 56 PN patients 13 matched healthy controls assayed for 54 biomarkers. We compared biomarker between HCs, among based on absolute count, across racial groups PN. Eleven...
Actinic keratoses (AKs) are premalignant intraepidermal neoplasms that occur as a result of cumulative sun damage. AKs commonly relapse, and up to 16% undergo malignant transformation into cutaneous squamous cell carcinoma. There is need for novel therapies reduce the quantity surface area well prevent carcinomas. We recently showed GZ17-6.02, an anticancer agent composed curcumin, haramine, isovanillin, inhibited growth H297.T cells. This study evaluated efficacy topical formulation known...
ABSTRACT Actinic keratoses (AKs) are premalignant intraepidermal neoplasms that occur as a result of cumulative sun damage. AKs commonly relapse, and up to 16% undergo malignant transformation into cutaneous squamous cell carcinoma (cSCC). There is need for novel therapies reduce the quantity surface area well prevent cSCCs. We recently showed GZ17-6.02, an anti-cancer agent composed curcumin, haramine, isovanillin, inhibited growth H297.T cells. The present study evaluated efficacy topical...
Abstract BACKGROUND Molecular characterization of glioblastomas by The Cancer Genome Atlas revealed molecular abnormalities in epidermal growth factor receptor (EGFR) over 50% glioblastomas. These included gene amplification, a large deletion ligand binding domain (EGFRvIII), kinase duplications and fusions. Our laboratory has been focusing on targeting EGFRvIII we noted heterogeneity. We found that inhibition EGFRvIII+ glioblastoma stem cell lines D317 D10-0171 osimertinib was different,...