A5069252128- Dermatology and Skin Diseases
- Urticaria and Related Conditions
- Asthma and respiratory diseases
- Autoimmune Bullous Skin Diseases
- Psoriasis: Treatment and Pathogenesis
- Cutaneous lymphoproliferative disorders research
- IL-33, ST2, and ILC Pathways
- T-cell and B-cell Immunology
- Contact Dermatitis and Allergies
- Viral Infections and Vectors
- Medicine and Dermatology Studies History
- Nail Diseases and Treatments
- Allergic Rhinitis and Sensitization
- Vector-borne infectious diseases
- Stroke Rehabilitation and Recovery
- Cancer-related Molecular Pathways
- Cerebral Palsy and Movement Disorders
- Oral Health Pathology and Treatment
- Nonmelanoma Skin Cancer Studies
- Muscle activation and electromyography studies
- Diabetes Management and Research
- Hidradenitis Suppurativa and Treatments
- Chemotherapy-related skin toxicity
- Skin Protection and Aging
- Clinical Reasoning and Diagnostic Skills
University of Maryland, Baltimore
2021-2025
Johns Hopkins Medicine
2021-2024
Johns Hopkins University
2021-2024
Defense Center for Public Health - Aberdeen
2021-2024
U.S. Army Center for Health Promotion and Preventive Medicine
2021-2024
Kennedy Krieger Institute
2021
Prurigo nodularis (PN) and chronic pruritus of unknown origin (CPUO) are pruritic diseases that dramatically impair quality life, but therapeutic options limited. Abrocitinib, a Janus kinase 1 inhibitor, represents promising therapy for both conditions.
Prurigo nodularis (PN) is a chronic, pruritic, inflammatory skin disease characterized by hyperkeratotic nodules on the trunk and extremities. While there growing research immunological basis of PN, neuropathic structural components PN lesions are unknown. This study examines inflammatory, neuropathic, pathways in compared to atopic dermatitis (AD) using RNA-sequencing lesional non-lesional tissue AD patients, as well immunohistochemistry analysis nerve growth factor (NGF), neurotrophic that...
Erythroderma is a severe and heterogeneous inflammatory skin condition with little guidance on the approach to management in cases of unknown etiology. To guide therapeutic selection, we sought create an immunophenotyping platform able identify aberrant cell populations cytokines subtypes erythroderma. We performed high-parameter flow cytometry peripheral blood mononuclear cells (PBMCs) whole patient refractory idiopathic erythroderma, erythrodermic patients Sézary syndrome pityriasis rubra...
Prurigo nodularis (PN) is a debilitating skin disease characterized by intense pruritus and hyperkeratotic nodules. Nemolizumab, monoclonal antibody targeting interleukin 31 receptor α, promising novel therapy for the treatment of moderate to severe PN. The biological mechanisms which nemolizumab promotes improvement itch lesions in PN are unknown.To characterize changes plasma protein biomarkers associated with clinical response patients PN.This multicenter cohort study included recruited...
Abstract Prurigo nodularis (PN) is an intensely pruritic, chronic inflammatory skin disease that disproportionately affects black patients. However, the pathogenesis of PN poorly understood. We performed single-cell transcriptomic profiling, ligand receptor analysis and cell trajectory 28,695 lesional non-lesional cells to uncover disease-identifying compositions genetic characteristics. uncovered a dysregulated role for fibroblasts (FBs) myofibroblasts as key pathogenic element in PN, which...
Abstract Prurigo nodularis (PN) is a chronic inflammatory skin disease that associated with variability in peripheral blood eosinophil levels and response to T-helper 2 targeted therapies (Th2). Our objective was determine whether circulating immune profiles respect type inflammation differ by race count. Plasma from 56 PN patients 13 matched healthy controls assayed for 54 biomarkers. We compared biomarker between HCs, among based on absolute count, across racial groups PN. Eleven...
We performed a cross-sectional study using validated survey instruments, finding severe pruritus, reduced quality of life (QoL) and significant mental health burden in diverse cohort patients with prurigo nodularis (PN) from the USA. Itch severity QoL scores were comparable to those found European populations, aside ItchyQoL (higher this US cohort). Black reported higher itch intensity than White patients. More 37% met cutoff for depression, but only 26% had clinical diagnosis depression....
Abstract A total of 2,504 ticks 5 species (Ixodes scapularis, Dermacentor variabilis, Amblyomma americanum, Haemaphysalis leporispalustris, and H. longicornis) were collected over 2 yr (2014–2015) in New York City parks. Specimens via tick-dragging, identified to species, tested for pathogens human diseases. The causative agents diseases (Lyme borreliosis, ehrlichiosis, babesiosis, anaplasmosis, Rocky Mountain spotted fever) detected a subset samples. Results this surveillance effort further...
Chronic pruritus (CP) is a poorly characterized condition associated with intense without primary skin eruption. This tends to emerge more commonly in older adults, and there limited research on triggering factors.
Prurigo nodularis (PN) is a chronic inflammatory skin disease characterized by intense pruritus and nodules. Beyond the skin, PN involves circulating blood inflammation that may contribute to systemic comorbidities. Dupilumab was recently approved for treatment of PN, but its effects on are unknown. Thus, we aimed characterize changes in plasma concentrations proteins following dupilumab treatment. In this exploratory study, samples were collected from three patients with moderate-to-severe...
Assessment of repetitive movements (e.g., finger tapping) is a hallmark motor examinations in several neurologic populations. These assessments are traditionally performed by human rater via visual inspection; however, advances computer vision offer potential for remote, quantitative assessment using simple video recordings. Here, we evaluated pose estimation approach measurement movement frequency from smartphone videos. Ten healthy young participants provided videos themselves performing...
Prurigo nodularis (PN) is a chronic inflammatory skin condition characterized by severely itchy and often painful bumps on the arms, legs, trunk. It unknown whether patients with PN have increased risk of developing sleep disorders.To evaluate association disorders.This retrospective, population-level, matched-cohort study was conducted using The Health Improvement Network. included 4193 newly diagnosed age, sex, race/ethnicity-matched controls. A Cox regression model used to assess...
This case report describes a patient in her 50s with 4-year history of brachioradial pruritus bilateral on upper arms and forearms.
Although pruritus is common in patients with hematologic cancers, it unknown whether undifferentiated have higher risk of developing cancer. Furthermore, unclear serum lactate dehydrogenase (LDH) level, commonly ordered for cancer workup, has diagnostic utility pruritus.To assess the and LDH level pruritus.This retrospective population-level cohort analysis was conducted using TriNetX Research Network, a global health records database encompassing more than 69 million patients, from 2002 to...
Lichen planus pigmentosum (LPP) is a rare, pigmented variant of lichen that characterized by hyperpigmented, dark brown to gray-black macules in sun-exposed areas the body such as face, neck, trunk, and flexures.1 This condition can cause considerable distress reduction quality life, but there are currently no approved therapies for LPP. Furthermore, existing treatments topical oral steroids, calcineurin inhibitors, retinoids, have limited success.
Abstract During September–December 2018, 25 live ticks were collected on-post at Fort Leavenworth, Kansas, in a home with history of bat occupancy. Nine sent to the Army Public Health Center Tick-Borne Disease Laboratory and identified as Carios kelleyi (Cooley Kohls, 1941), species that seldom bites humans but may search for other sources blood meals, including humans, when bats are removed from human dwellings. The tested numerous agents disease. Rickettsia lusitaniae was by multilocus...
Objective This article describes a novel clinical rotation that uses technology to create remote ophthalmology learning experience with the goal of improving virtual exposure medical and surgical ophthalmic training for students. Methods Our unique curriculum incorporates mobile-mounted tablets which allow students virtually participate in inpatient consults, clinic, surgery. An adaptable mounting device attached slit lamp allows observe examinations real time, enhancing recognition ocular...