A5101631051- Dermatology and Skin Diseases
- Asthma and respiratory diseases
- IL-33, ST2, and ILC Pathways
- Urticaria and Related Conditions
- Renal Diseases and Glomerulopathies
- Genetics and Neurodevelopmental Disorders
- Autoimmune Bullous Skin Diseases
- Renal and related cancers
- Wound Healing and Treatments
- Allergic Rhinitis and Sensitization
- Immune Cell Function and Interaction
- Cutaneous lymphoproliferative disorders research
- Renal cell carcinoma treatment
- Nail Diseases and Treatments
- Stress Responses and Cortisol
- T-cell and B-cell Immunology
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Systemic Lupus Erythematosus Research
- Psoriasis: Treatment and Pathogenesis
- Colorectal and Anal Carcinomas
- Otitis Media and Relapsing Polychondritis
- Global Healthcare and Medical Tourism
- Adenosine and Purinergic Signaling
- Hidradenitis Suppurativa and Treatments
Johns Hopkins Medicine
2023-2025
Johns Hopkins University
2023-2025
University of Maryland, Baltimore
2024-2025
Boston Children's Museum
2022-2024
Boston Children's Hospital
2022-2024
King Abdulaziz University
2024
Harvard University
2022-2024
To assess the efficacy of anifrolumab, a type-1 interferon receptor subunit-1 monoclonal antibody, in treating refractory cutaneous lupus erythematosus (CLE) and non-specific mucocutaneous manifestations patients with systemic (SLE).
This cohort study examines the prevalence and outcomes of misdiagnosing dermatomyositis or clinically amyopathic diagnosis.
This retrospective study investigates the role of baseline immunoglobulin E (IgE) levels in predicting therapeutic response to dupilumab prurigo nodularis (PN) patients. Our findings show that patients with elevated IgE experienced significantly greater relief from pruritus, suggesting could serve as a biomarker for identifying individuals who are more likely benefit IL-4 and IL-13-targeted therapies. These results support development personalized treatment strategies based on inflammatory...
Abstract Prurigo nodularis (PN) is a chronic inflammatory skin disease that associated with variability in peripheral blood eosinophil levels and response to T-helper 2 targeted therapies (Th2). Our objective was determine whether circulating immune profiles respect type inflammation differ by race count. Plasma from 56 PN patients 13 matched healthy controls assayed for 54 biomarkers. We compared biomarker between HCs, among based on absolute count, across racial groups PN. Eleven...
Importance Central centrifugal cicatricial alopecia (CCCA) is a scarring predominantly affecting Black female individuals. Current conventional treatments target inflammation but not the underlying fibrotic processes, often leading to permanent hair loss. Objective To investigate associations of low-dose oral metformin, an antidiabetic medication with antifibrotic properties, clinical symptoms and scalp gene expression patterns in patients CCCA. Design, Setting, Participants This...
Chronic pruritus (CP) is a poorly characterized condition associated with intense without primary skin eruption. This tends to emerge more commonly in older adults, and there limited research on triggering factors.
Prurigo nodularis (PN) is a chronic inflammatory skin disease characterized by intense pruritus and nodules. Beyond the skin, PN involves circulating blood inflammation that may contribute to systemic comorbidities. Dupilumab was recently approved for treatment of PN, but its effects on are unknown. Thus, we aimed characterize changes in plasma concentrations proteins following dupilumab treatment. In this exploratory study, samples were collected from three patients with moderate-to-severe...
Abstract Background Atopic dermatitis (AD) may affect cognitive function, but studies are limited and inconsistent. The effect of AD severity on cognition remains underexplored few previous have examined clinically validated or repeated measures throughout childhood. Objectives To evaluate the relationship activity with general in a longitudinal birth cohort. Methods We conducted cross-sectional analyses using data from Avon Longitudinal Study Parents Children (ALSPAC), UK cohort 14 975...
Abstract Background: Steroid-resistant nephrotic syndrome is the second leading cause of chronic kidney disease among patients <25 years age. Through whole exome sequencing, identification >65 monogenic causes has rendered insights into mechanisms syndrome. Methods: To elucidate novel NS, we combined homozygosity mapping with ES in a worldwide cohort 1649 pediatric NS. Results: We identified homozygous missense variants MYO1C two unrelated children (c.292C>T, p.R98W; c.2273 A>T,...