A5067457908- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Urological Disorders and Treatments
- Urinary Bladder and Prostate Research
- Pediatric Urology and Nephrology Studies
- Esophageal Cancer Research and Treatment
- Pelvic floor disorders treatments
- Cancer survivorship and care
- Congenital heart defects research
- Cancer Risks and Factors
- Enhanced Recovery After Surgery
- Renal and Vascular Pathologies
- Nephrotoxicity and Medicinal Plants
- Metastasis and carcinoma case studies
- Occupational and environmental lung diseases
- Tea Polyphenols and Effects
- Health Systems, Economic Evaluations, Quality of Life
- Birth, Development, and Health
- Renal and related cancers
- BRCA gene mutations in cancer
- Cancer Diagnosis and Treatment
- Global Cancer Incidence and Screening
- Urinary Tract Infections Management
- Sexual function and dysfunction studies
- Nutritional Studies and Diet
University of Sheffield
2018-2024
Sheffield Teaching Hospitals NHS Foundation Trust
2020-2024
University of Minnesota Rochester
2020
New York Proton Center
2020
McGill University
2020
Galveston College
2020
Kansas City Public Schools
2020
Cambridge University Hospitals NHS Foundation Trust
2018
Addenbrooke's Hospital
2018
University of Cambridge
2018
BackgroundLittle is known about contemporary lifestyle choices in patients with bladder cancer (BC). These include carcinogenic risk factors and could affect fitness to receive treatments.ObjectiveTo evaluate the BC patients.Design, setting, participantsSelf-reported surveys from participants diagnosed previous 10 yr captured smoking patterns, e-cigarette use, physical activity using GODIN Leisure-Time Exercise Questionnaire, long-term conditions (LTCs), relationship status,...
Objectives To describe the health‐related quality of life (HRQoL) patients in a prospective 12‐month observational cohort study new bladder cancer diagnoses and compare with national general population surveys. Patients Methods A UK at 13 NHS Trusts. The HRQoL data were collected 3, 6, 9 12 months. Questionnaires used included: EuroQoL five Dimensions (EQ‐5D), European Organisation for Research Treatment Cancer questionnaire (EORTC QLQ)‐30‐item core, EORTC QLQ‐24‐item non‐muscle‐invasive...
Uroplakins are a family of membrane-spanning proteins highly specific to the urothelium. There four uroplakin in humans. These encoded by following UPK genes: UPK1A , UPK1B UPK2 and UPK3 . Uroplakin span apical membrane umbrella cells urothelium, where they associate into urothelial plaques. This provides barrier function prevent passage urine across urothelium renal pelvis, ureters, bladder. also involved developmental processes such as nephrogenesis. The localisation uroplakins within...
Objectives Up to 10% of Bladder Cancers may arise following occupational exposure carcinogens. We hypothesised that different cancer phenotypes reflected patterns exposure. Methods Consecutive participants, with bladder cancer, self-completed a structured questionnaire detailing employment, tasks, exposures, smoking, lifestyle and family history. Our primary outcome was association between phenotype details. Results collected questionnaires from 536 patients, whom 454 (85%) participants (352...
Ureteroscopy and laser fragmentation of stones is a commonly used method to treat ureteric renal calculi. We report the exceedingly rare finding pseudoaneurysm in an interpolar artery following ureteroscopy stone fragmentation, which was successfully managed with angioembolisation.
ABSTRACT Background Sexual dysfunction is common in those affected by cancer and local radical treatments for Bladder Cancer (BC) can affect sexual function directly. Aim To evaluate following a bladder diagnosis. Methods Self-reported was collected 10 years after diagnosis of BC as part cross-sectional patient reported outcome measure (PROM) survey exploring life treatment. Outcomes Participants completed combined EORTC QLQ-BLM30 QLQ-NMIBC24 questionnaire, including questions on activity,...
Objective To report real‐world outcomes for high‐risk non‐muscle‐invasive bladder cancer (HRNMIBC), including bacillus Calmette‐Guérin (BCG) and radical cystectomy (RC), as randomised comparisons of these have not been possible. Methods We detail consecutive participants screened the BRAVO controlled trial comparing RC with BCG (International Standard Randomised Controlled Trial Number [ISRCTN]12509361). Patients were prospectively registered case‐note review used outcomes. The primary...
The objectives of the study are to explore tolerability, acceptability and oncological outcomes for patients with high-risk non-muscle-invasive bladder cancer (NMIBC) treated hyperthermic intravesical chemotherapy (HIVEC) mitomycin-C (MMC) at our institution.Our single-institution, observational consists consecutive NMIBC HIVEC MMC. Our protocol included six weekly instillations (induction), followed by two further cycles three (maintenance) (6 + 3 3) if there was cystoscopic response....
In England, guidance from National Institute for Clinical Excellence (NICE) states women with a family history of breast cancer presenting to primary care should be reassured or referred.We reviewed the evidence interventions that might applied in and conducted an audit whether low risk are correctly advised flagged.We literature review identify modifiable factors. We extracted routinely collected data computerised medical record systems 6 general practices (population approximately 30,000);...
Little is known about the distal excretory component of urinary tract in Danio rerio (zebrafish). This affected by many human diseases and disorders development. Here, we have undertaken multi-level analyses to determine structure composition zebrafish. In silico searches identified uroplakin 1a (ukp1a), 2 (upk2) 3b (upk3b) genes zebrafish genome (orthologues that encode urothelium-specific proteins humans). situ hybridization demonstrated ukp1a expression pronephros cloaca from 96 h...
Bochdalek hernias occur as a result of congenital defect in the diaphragm enabling abdominal viscera to enter thoracic cavity restricting lung expansion and ventilation. hernias, majority cases, present neonates very rarely adults. To best our knowledge, there are only four published cases hernia adult population causing respiratory failure. We case an 87-year-old woman who had three admissions past 6 months with type II failure due which we believe was but gradually increased size over...
Abstract Little is known about the distal excretory component of urinary tract in Danio rerio (zebrafish). This affected by many human diseases and disorders development. Here, we undertook multi-level analyses to determine structure composition zebrafish. In silico searches identified uroplakin 1a, 2-like 3-like genes zebrafish genome (orthologues that encode proteins characterise urothelium humans). situ hybridization demonstrated uroplakin-1a expression pronephros cloaca from 96 hours...