A5055566451- Gut microbiota and health
- Inflammatory Bowel Disease
- Escherichia coli research studies
- Antibiotic Resistance in Bacteria
- Bacterial biofilms and quorum sensing
- Vibrio bacteria research studies
- Cancer Research and Treatments
- Microscopic Colitis
- Spondyloarthritis Studies and Treatments
- Eosinophilic Esophagitis
- Antimicrobial Resistance in Staphylococcus
- Infant Nutrition and Health
- Pharmacological Effects of Natural Compounds
- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Helicobacter pylori-related gastroenterology studies
- Mycobacterium research and diagnosis
- Immune Response and Inflammation
- Venomous Animal Envenomation and Studies
Cornell University
2019-2025
Weill Cornell Medicine
2019-2022
Miami University
2016-2021
Acinetobacter baumannii is an opportunistic Gram-negative pathogen that causes a wide range of infections including pneumonia, septicemia, necrotizing fasciitis and severe wound urinary tract infections. Analysis A. representative strains grown in Chelex 100-treated medium for hemolytic activity demonstrated this increasingly to sheep, human horse erythrocytes, which interestingly contain increasing amounts phosphatidylcholine their membranes. Bioinformatic, genetic functional analyses 19...
Joint inflammation is the most common extraintestinal manifestation of Crohn's disease (CD). Although alterations in enteric microbiota are described CD with spondyloarthritis (CD-SpA), it not known whether distinct taxa serve as markers for clinical subtypes axial (AxSpA) or peripheral SpA (pSpA) CD. Moreover, yet these generate a specific systemic IgG response. Here, we sequenced fecal microbiome from 106 individuals (44 CD, 39 CD-SpA, 14 CD-AxSpA, and 9 healthy controls [HC]). This unique...
The capacity of Acinetobacter baumannii to persist and cause infections depends on its interaction with abiotic biotic surfaces, including those found medical devices host mucosal surfaces. However, the extracellular stimuli affecting these interactions are poorly understood. Based our previous observations, we hypothesized that mucin, a glycoprotein secreted by lung epithelial cells, particularly during respiratory infections, significantly alters A. baumannii's physiology surrounding...
Acinetobacter baumannii has been recognized as a critical pathogen that causes severe infections worldwide not only because of the emergence extensively drug-resistant (XDR) derivatives, but also its ability to persist in medical environments and colonize compromised patients. While there are numerous reports describing mechanisms by which this acquires resistance genes, little is known regarding A. ’s virulence functions associated with rare manifestations infection such necrotizing...
Abstract Background Our lab has recently shown that adherent-invasive E. coli (AIEC), which is enriched in patients with Crohn’s disease, sufficient to induce intestinal Th17 cell inflammation. Although AIEC lack pathogenic factors including type III secretion systems, virulence-associated metabolic enzymes, propanediol dehydratase (PduC), enable use fucose-derived as an alternate carbon source the gut. We hypothesised this utilisation pathway functionally modulates contribution tissue...
Abstract While the molecular mechanisms by which microbiome modulates mucosal immunity in Crohn’s disease (CD) are still largely unknown, recent data highlight involvement of specific diet- and bacterial-derived metabolites regulation intestinal immune cell activation differentiation. We have recently shown that Adherent-Invasive E.coli (AIEC), enriched CD patients, sufficient to induce Th17 cells. Although AIEC lack pathogenic factors including type III secretion systems, many CD-derived...
Abstract Crohn’s Disease (CD) has been associated with alterations in the intestinal microbiota, but microbial mechanisms that regulate host immunity are largely unknown. We have recently shown Adherent-Invasive E. coli (AIEC), which enriched CD patients, sufficient to induce Th17 cells. Although AIEC lack pathogenic factors including type III secretion systems, many CD-derived isolates express virulence-associated metabolic enzymes propanediol dehydratase (PduC), enables use fucose-derived...
Abstract Spondyloarthritis (SpA) is the most common extra-intestinal manifestation of inflammatory bowel disease (IBD). Sulfasalazine (SAS) one earliest medications used in IBD and its efficacy spondyloarthritis thought to depend on antibacterial properties. Therefore, our study aims diagnostically evaluate role for fecal microbiome clinical response SAS identify microbial immunologic therapeutic targets associated with response. We have longitudinally followed IBD-SpA patients subjected...
Abstract Background Bacterial constituents of the intestinal microbiota can contribute to local and systemic inflammatory diseases. Crohn's disease (CD), a type bowel disease, result in extraintestinal manifestations (EIM) including peripheral (CD-SpA) axial spondyloarthritis (CD-AxSpA). Microbial contributors CD pathogenesis be identified by flow cytometric sorting 16S sequencing bacteria recognized mucosal IgA. We expand this technique incubating fecal samples with autologous sera,...