Probiotics have been found to beneficial effects on bone metabolism. In this randomized, double-blind, placebo-controlled trial, the of multispecies probiotic supplementation turnover markers were evaluated after 12 weeks. Forty postmenopausal women with osteopenia included and randomly divided into two groups. The intervention group received probiotics, while control identical placebo sachets daily. baseline characteristics both groups similar. Still, median serum resorption marker...

Immune dysregulation can involve invasion and survival of endometrial glands inside the myometrium adenomyosis. There is limited available data concerning alterations bacterial microbiome in reproductive tract adenomyosis women. The present cross-sectional age-matched study aims to compare vaginal microbiota between women with without We recruited (N = 40) from Departments Obstetrics Gynaecology, Ramathibodi Hospital Mahidol University, August 2020 January 2021. Vaginal swab samples were...

Chronic insomnia disorder is one of the most common problems in postmenopausal women, exacerbated by underdiagnosis and improper treatment. This double-blinded, randomized, placebo-controlled trial was conducted to evaluate potential vitamin E treat chronic as an alternative sedative drugs hormonal therapy. The study enrolled 160 women with disorder, divided randomly into two groups. group received 400 units mixed tocopherol daily, while placebo identical oral capsule. primary outcome this...

To compare the effects of a 12-week treatment with Pueraria mirifica (PM) gel or conjugated estrogen cream on vaginal maturation index, symptom score, health assessment and flora in postmenopausal women.In prospective, noninferiority, randomized controlled study, 82 women at least one vulvovaginal symptom, that is, dryness, soreness, irritation, dyspareunia, discharge, were recruited. Participants randomly assigned into two groups for either PM (CEE). The regimen consisted application 0.5 g...

Background Left ventricular ( LV ) diastolic dysfunction often precedes heart failure with preserved ejection fraction, the dominant form of in postmenopausal women. The objective this study was to determine effect oral estradiol treatment initiated early after ovariectomy on function and myocardial gene expression female cynomolgus macaques. Methods Results Monkeys were ovariectomized randomized receive placebo (control) or at a human‐equivalent dose 1 mg/day for 8 months. then underwent...

Vitamin E is a strong anti-oxidative stress agent that affects the bone remodeling process. This study evaluates effect of mixed-tocopherol supplements on in postmenopausal osteopenic women. A double-blinded, randomized, placebo-controlled trial was designed to measure turnover marker after 12 weeks supplementation. All 52 women were enrolled and allocated into two groups. The intervention group received 400 IU/day, while control placebo tablets. Fifty-two participants completed follow-up....

The differential diagnosis between uterine fibroid and adenomyosis is sometimes difficult; a precise required in women with infertility because of the different choice treatments. Ultrasound elastography (UE) novel technique to evaluate elasticity or stiffness tissue interest. present study aims compare UE shear wave velocity (SWV) among normal myometrium, fibroid, adenomyosis, assess accuracy adenomyosis.This cross-sectional recruited 25 subjects for each group (control, fibroid) from April...

Polycystic ovarian syndrome (PCOS) is a common and complex condition characterized by endocrine features influenced genetic environmental factors. In Southeast Asia Thailand, the prevalence of PCOS unknown. The aim this study was to estimate determine factors associated with in Thai adolescents. We administered validated questionnaire 600 university female participants aged 17-19 years from Mahidol University Bangkok. Of these, 548 (91.33%) responded agreed participate. Two-hundred...

Polycystic ovary syndrome (PCOS) and nonalcoholic fatty liver (NAFLD) share similar clinical presentations including obesity, insulin resistance (IR), metabolic abnormality. The predictive factors of NAFLD in women with PCOS specifically Asian are not well established. Associated for assessed by ultrasound (US) among a group healthy were determined diagnostic accuracy between US transient elastography (TE) was compared correlated. Sixty-three ages ranging from 20 to 40 years participated the...

The effects of oral vitamin D supplements on vaginal health in postmenopausal women with vulvovaginal atrophy (VVA) was evaluated. A double-blinded, randomized placebo-controlled trial conducted for 12 weeks to investigate changes maturation index (VMI), pH, and the visual analog scale (VAS) VVA symptoms. group received ergocalciferol, at 40,000 IU per week, while placebo an identical capsule. Eighty were enrolled. There no significant differences baseline characteristics between both...

Polycystic ovary syndrome (PCOS) is a common gynaecological problem for women of reproductive age. Depression and anxiety are conditions that occur in with PCOS have an impact on mental well-being. However, there lack data their prevalence its associated factors the Thai population. This cross-sectional study aimed to evaluate depression among identify as well well-being Thailand.

The aim of this study was to determine the effects estrogen therapy (ET) on carotid artery inflammation when initiated early and late relative surgical menopause.Female cynomolgus macaques consuming atherogenic diets were ovariectomized randomized control or oral estradiol (E2; human equivalent dose 1 mg/d micronized E2) at month (early menopause, n = 24) 54 months (late 40) after ovariectomy. treatment period 8 months. Carotid expression markers monocyte/macrophages (CD68 CD163), dendritic...

Simvastatin is a promising new drug for the treatment of endometriosis. It cholesterol-lowering that acts by inhibiting HMG-CoA reductase, resulting in decrease mevalonate, precursor cholesterol and monocyte chemoattractant protein-1 (MCP-1). This study investigated effect pre-operative oral simvastatin administration on MCP-1 gene expression serum protein levels patients with A prospective, randomized, controlled was conducted at Reproductive Endocrinology Unit Department Obstetrics...

Progestin has been used for symptomatic treatment of adenomyosis, although its effect on the immune system not studied. The aim this study was to investigate changes macrophage and natural killer (NK) cell infiltration in tissues obtained from women with adenomyosis who did or receive oral progestin dienogest.In randomized controlled clinical trial study, 24 patients required hysterectomy were enrolled. Twelve received dienogest 28-35 days before surgery, other 12 treated any hormones....

Abstract Aim: To compare the efficacy of 1000 mg and 1700 metformin on ovulation induction in polycystic ovary syndrome (PCOS) women. Material Methods: A randomized controlled trial was conducted at Ramathibodi Hospital, Mahidol University, Bangkok, Thailand 60 PCOS women diagnosed by Rotterdam criteria. Group (30 women) B received mg/day metformin, respectively. Clomiphen citrate 50–150 per day for 5 days added, if no dominant follicle developed. The main outcome measures were pregnancy...

Melioidosis, the disease caused by Burkholderia pseudomallei is endemic in Northeastern part of Thailand, South-East Asia, and Northern Australia. The pelvic involvement rare even an area. Therefore, we describe this report clinical presentation, management, outcome patient with primary tubo-ovarian abscess due to melioidosis. A 31-year-old Thai cassava farmer woman presented fever abdominal pain at left lower quadrant for one month. She also had pain, swelling, redness genitalia without any...

Abstract Aim: To determine whether minimal stimulation with clomiphene and gonadotropin provides outcomes direct costs comparable those of a conventional GnRHa‐gonadotropin protocol for infertile patients undergoing in vitro fertilization. Methods: A non‐randomized clinical trial was conducted from 1 July 1996 to 31 March 2003 at the Infertility Assisted Reproductive Unit, Ramathibodi Hospital, Faculty Medicine, Mahidol University, Thailand. total 192 were recruited whom 96 cases underwent...

Background . There have been few reports of nucleotide analogue-related renal tubular dysfunction (RTD) in CHB patients. We assessed the prevalence and presentation proximal RTD. Methods A cross-sectional study was performed patients taking analogues. Inclusion criteria were who on adefovir or tenofovir as mono- add-on therapy with lamivudine (LAM) >1 year. Serum urine collected. Fractional excretion phosphate (FEPO 4 ), uric acid (FEUA), potassium calculated. Renal losses defined based...

Objective: Since endometriosis is an estrogen-dependent disease; therefore, combined oral contraceptives (COCs) may not be the best choice for treatment of endometriosis. The objective present study was to investigate effects ethinyl estradiol (EE) and desogestrel (DSG) in COCs on cell proliferation apoptosis ectopic endometrial tissue as compared DSG alone. Materials methods: Forty-five women reproductive age with at least one endometriotic cyst were recruited into this single-blind...

The aim of this study was to assess the efficacy metformin on induction ovulation in Asian women with clomiphene citrate (CC)-resistant polycystic ovary syndrome (PCOS). Twenty PCOS who did not respond CC were enrolled study. All received 500-1500 mg/day for 4 weeks. If no dominant follicle observed monitoring by transvaginal ultrasound, 50-150 mg per day 5 days added. Timing sexual intercourse determined or intrauterine insemination carried out 36 h after administration human chorionic...