A5078889061- Diabetes Treatment and Management
- Pancreatic function and diabetes
- Diet and metabolism studies
- Dietary Effects on Health
- Gut microbiota and health
- Neuropeptides and Animal Physiology
- Diet, Metabolism, and Disease
- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Circadian rhythm and melatonin
- Metabolism, Diabetes, and Cancer
- Nutrition, Genetics, and Disease
- Genetics, Aging, and Longevity in Model Organisms
- Biochemical Analysis and Sensing Techniques
- Cancer, Hypoxia, and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Eating Disorders and Behaviors
- Vitamin D Research Studies
- Monoclonal and Polyclonal Antibodies Research
- CAR-T cell therapy research
- Food composition and properties
- Biotin and Related Studies
- Birth, Development, and Health
- Metabolomics and Mass Spectrometry Studies
- Advanced Drug Delivery Systems
University of Oulu
2014-2024
Oulu University Hospital
2017-2024
Science for Life Laboratory
2024
Uppsala University
2024
Imperial College London
2024
Istanbul Kent University
2024
Shanghai Jiao Tong University
2020-2022
Nuclear Institute for Agriculture and Biology
2009
Obesity and dyslipidemia are hallmarks of metabolic cardiovascular diseases. Polydextrose (PDX), a soluble fiber has lipid lowering effects. We hypothesize that PDX reduces triglycerides cholesterol by influencing gut microbiota, which in turn modulate intestinal gene expression. C57BL/6 male mice were fed Western diet (WD) ±75 mg twice daily oral gavage for 14 days. Body weight food intake monitored daily. Fasting plasma lipids, caecal microbiota expression intestine liver measured after...
Postprandial lipemia is a risk factor for cardiovascular disease. Dairy products differ in nutrient content and food matrix, little known about how different dairy affect postprandial triglyceride (TG) concentrations.We investigated the effect of meals with similar amounts fat from on TG concentrations over 6 h healthy adults.A randomized controlled cross-over study was performed 47 subjects (30% men), median (25th-75th percentile) age 32 (25-46) y body mass index 23.6 (21.0-25.8) kg/m2....
Insoluble residue (INS) is a lignin-rich fraction of brewer's spent grain (BSG) that also contains β-glucan and arabinoxylan, the major constituents dietary fiber. We investigated effects INS in diet-induced obese mice terms lipid metabolism metabolic diseases. Male (C57bl6) were fed high-fat diet (HFD), HFD + 20% INS, cellulose (CEL), with combination INS-CEL (1:1), or control for 14 weeks. Insulin glucose tolerance tests performed after 12 Fasting plasma lipids, bile acid, fecal acid...
Inflammation plays a significant role in pathogenesis of diabetes and atherosclerosis. Increased adiposity with an upregulation cytokines prediabetes has been associated vascular inflammation considered leading causal factor for type 2 (T2D). Information on adipokines inflammatory markers prediabetes, defined by hemoglobin A1C (HbA1c) 5.7-6.4% addition to impaired fasting glucose (IFG) tolerance (IGT), are sparse. We conducted population-based cross-sectional study (part follow-up study)...
Obesity is a risk factor for cardiometabolic diseases. Nutrients stimulate GLP-1 release; however, has short half-life (<2 min), and only <10–15% reaches the systemic circulation. Human L-cells are localized in distal ileum colon, while most nutrients absorbed proximal intestine. We hypothesized that combinations of amino acids fatty potentiate release via different L-cell receptors. secretion was studied mouse enteroendocrine STC-1 cells. Cells were pre-incubated with buffer 1 h...
Abstract Transmembrane prolyl 4-hydroxylase (P4H-TM) is an enigmatic enzyme whose cellular function and primary substrate remain to be identified. Its loss-of-function mutations cause a severe neurological HIDEA syndrome with hypotonia, intellectual disability, dysautonomia hypoventilation. Previously, P4H-TM deficiency in mice was associated reduced atherogenesis lower serum triglyceride levels. Here, we characterized the glucose lipid metabolism of P4h-tm −/− physiological tissue analyses....
Massage therapy increases muscle blood flow and heat, relieving pain, improving immune function, increasing vagal activity. The mechanisms are unclear. Muscles release cytokines other peptides called myokines. These myokines exert their effects on different tissues organs in para-, auto-, endocrine fashion. aim of this intervention study was to investigate if massage affects circulating myokine levels. A total 46 healthy, normal-weight subjects (15 men) aged 18–35 were recruited. Forty-five...
Background Pandemic vitamin D deficiency is associated with insulin resistance and type 2 diabetes. Vitamin supplementation has been reported to have improved glucose homeostasis. However, its mechanism improve sensitivity remains unclear. Methods results Male C57BL/6J mice are fed with/without control (CD) or Western (WD) diets for 15 weeks. The vitamin‐D‐deficient lean (CDVDD) obese (WDVDD) further subdivided into two groups. One group re‐supplemented 6 weeks hepatic signaling examined....
Polydextrose (PDX) reduces subsequent energy intake (EI) when administered at midmorning in single-blind trials of primarily normal-weight men. However, it is unclear if this effect also occurs PDX given breakfast time. Furthermore, for ecological validity, desirable to study a female population, including those risk obesity. We studied the effects PDX, served as part or preload, on EI and other appetite-related parameters healthy overweight females. Per earlier studies, primary outcome was...
Metabolic adaptation and signal integration in response to hypoxic conditions is mainly regulated by hypoxia-inducible factors (HIFs). At the same time, hypoxia induces ROS formation activates unfolded protein (UPR), indicative of endoplasmic reticulum (ER) stress. However, whether ER stress would affect remains ill-defined. Here we report that feeding mice a high fat diet causes attenuates hypoxia. Mechanistically, promotes HIF-1α HIF-2α degradation independent ROS, Ca2+, von Hippel-Lindau...
Scope Diet and exercise are significant players in obesity metabolic diseases. Time‐restricted feeding (tRF) has been shown to improve responses by regulating circadian clocks but whether it acts synergically with remains unknown. It is hypothesized that forced alone or combined tRF alleviates its complications. Methods results Male C57bl6 mice fed high‐fat a control diet for 12 weeks either ad libitum 10 h during their active period. High‐fat (HFD)‐fed divided into (treadmill 1 at m min −1...
Brewer's spent grain (BSG) is the major side-stream from brewing. As BSG rich in dietary fiber and protein, it could be used more valuable applications, such as nutritional additives for foods. Our aim was to elucidate whether an insoluble lignin-rich fraction (INS) metabolized by mice gut microbiota how affects microbiota. results indicated that lignin partially degraded microbiota, degradation products were absorbed, finally excreted urine. Therefore, they contribute phenolic pool...
Abstract Polydextrose (PDX) is a branched glucose polymer, utilized as soluble dietary fiber. Recently, PDX was found to have hypolipidemic effects and on the gut microbiota. To investigate these findings more closely, non-targeted metabolomics approach, exploited determine metabolic alterations in blood epididymal adipose tissue samples that were collected from C57BL/6 mice fed with Western diet, or without oral administration of PDX. Metabolomic analyses revealed significant differences...
Alcoholic beverages stimulate pancreatic enzyme secretions by inducing cholecystokinin (CCK) release. CCK is the major stimulatory hormone of exocrine secretions, secreted from enteroendocrine I-cells intestine. Fermentation products alcoholic beverages, such as maleic and succinic acids, influence gastric acid secretions. We hypothesize that acids during beer wine ingestion increasing Therefore, effects on release were studied in duodenal mucosal cells cell line STC-1. Mucosal perfused for...
Slc26a9 is a member of the Slc26 multifunctional anion transporter family. Polymorphisms in are associated with an increased incidence meconium ileus and diabetes cystic fibrosis patients. We investigated expression murine pancreatic ducts, islets parenchyma, elucidated its role ductal electrolyte fluid secretion endocrine function.Pancreatic CFTR mRNA expression, bicarbonate were assessed slc26a9-/- mice their age- sex-matched wild-type (wt) littermates. Glucose insulin tolerance tests...
There has been a substantial and consistent rise in the number of clinical trials to develop advanced potent bispecific antibodies (BsAb) over past two decades with multiple targets improve efficacy or tissue specificity monoclonal (mAb) treatment for diseases determining factors widely-expressed targets. In this study, we designed synthesized BsAb AGR2xPD1 targeting extracellular AGR2, paracrine signal, PD1, an immune checkpoint protein. Our design is intended use AGR2 binding guide PD1...
Nutrients stimulate the secretion of glucagon-like peptide-1 (GLP-1), an incretin hormone, secreted from enteroendocrine L-cells which decreases food intake. Thus, GLP-1 analogs are approved for treatment obesity, yet cost and side effects limit their use. mainly localized in distal ileum colon, hinders utilization nutrients targeting secretion. This study proposes a controlled delivery system nutrients, inducing prolonged endogenous release results decrease intake.α-Linolenic acid (αLA) was...
Low-carbohydrate high-fat (LCHF) diets may suppress the increase in appetite otherwise seen after diet-induced fat loss. However, studies of without severe energy restriction are lacking, and effects carbohydrate quality relative to quantity have not been directly compared. To evaluated short- (3 mo) long-term (12 changes fasting plasma concentrations total ghrelin, β-hydroxybutyrate (βHB), subjective feelings on 3 isocaloric eating patterns within a moderate caloric range (2000–2500 kcal/d)...