A5076579729- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Metal-Organic Frameworks: Synthesis and Applications
- HIV Research and Treatment
- Advanced biosensing and bioanalysis techniques
- Viral Infections and Immunology Research
- Mesoporous Materials and Catalysis
- Advanced Nanomaterials in Catalysis
- Carbohydrate Chemistry and Synthesis
- Mass Spectrometry Techniques and Applications
- RNA Interference and Gene Delivery
- Glycosylation and Glycoproteins Research
- Cancer therapeutics and mechanisms
- Pigment Synthesis and Properties
- Advanced Proteomics Techniques and Applications
- Graphene and Nanomaterials Applications
- Hepatitis C virus research
- Luminescence and Fluorescent Materials
- Photochromic and Fluorescence Chemistry
- MicroRNA in disease regulation
- Boron and Carbon Nanomaterials Research
- DNA Repair Mechanisms
- HIV/AIDS Research and Interventions
- Porphyrin and Phthalocyanine Chemistry
- Covalent Organic Framework Applications
Instituto de Tecnología Química
2016-2024
Consejo Superior de Investigaciones Científicas
2016-2024
Universitat Politècnica de València
2016-2024
Instituto de Química Médica
2012-2019
Diagnostic tests based on proteomics analysis can have significant advantages over more traditional biochemical tests. However, low molecular weight (MW) protein biomarkers are difficult to identify by standard mass spectrometric analysis, as they usually present at concentrations and masked abundant resident proteins. We previously shown that mesoporous silica nanoparticles able capture a predominantly MW fraction from the serum, compared corona (PC) adsorbed onto dense nanoparticles. In...
Although docetaxel is currently broadly used in prostate cancer treatment, poor water solubility and systemic toxicity limit the dose duration of therapy. In this context, although different nanoplatforms have been proposed to overcome these issues, selective therapy needs developing methodologies target malignant cells minimizing impact on healthy tissue. We here present a novel drug delivery system obtained by covalent conjugation an anti-prostate specific membrane antigen (PSMA) molecule...
Docetaxel (DTX) is a recommended treatment in patients with metastasic prostate cancer (PCa), despite its therapeutic efficacy limited by strong systemic toxicity. However, localized PCa, intratumoral (IT) administration of DTX could be an alternative to consider that may help overcome the disadvantages conventional intravenous (IV) therapy. In this context, we here present first vivo preclinical study PCa therapy nanomedicines mesoporous silica nanoparticles (MSN) and IT injection over...
Enterovirus A71 (EV-A71) is a non-polio neurotropic enterovirus with pandemic potential. There are no antiviral agents approved to prevent or treat EV-A71 infections. We here report on the molecular mechanism by which novel class of tryptophan dendrimers inhibits (at low nanomolar high picomolar concentration) replication in vitro. A lead compound series (MADAL385) prevents binding and internalization virus but does not, unlike classical capsid binders, stabilize particle. By means...
The " ship in a bottle principle applied to drug delivery. A photoswitchable prodrug is endowed tailored-pore mesoporous silica nanoparticles. Drug loading and release controlled by photoisomerization.
We have recently described a new class of dendrimers with tryptophan (Trp) on the surface that show dual antiviral activities against HIV and EV71 enterovirus. The prototype compound this family is pentaerythritol derivative 12 Trps periphery. Here we complete structure-activity relationship studies to identify key features might be significant for activity. With aim, novel containing different amino acids (aromatic non-aromatic), tryptamine (a "decarboxylated" analogue Trp) N-methyl Trp...
A novel therapeutic approach for glioblastoma multiforme (GBM) therapy has been carried out through in vitro and vivo testing by using the prodrug camptothecin-20-O-(5-aminolevulinate) (CPT-ALA). The incorporation of ALA to CPT may promote uptake cytotoxic molecule cells where heme synthesis pathway is active, improving action reducing side effects over healthy tissue. antitumor properties CPT-ALA have tested on different GBM cell lines (U87, U251, C6) as well an orthotopic model rat,...
ABSTRACT Tryptophan dendrimers that inhibit HIV replication by binding to the envelope glycoproteins gp120 and gp41 have unexpectedly also proven be potent, specific, selective inhibitors of unrelated enterovirus A71. Dendrimer 12, a consensus compound was synthesized on basis structure-activity relationship analysis this series, is 3-fold more potent against BrCr lab strain and, surprisingly, inhibits large panel clinical isolates in low-nanomolar/high-picomolar range.
Gd and Fe centers closely packed in a Gd(H<sub>2</sub>O)<sub>4</sub>[Fe(CN)<sub>6</sub>]@SiO<sub>2</sub>network promote magnetic synergistic effect, which improves longitudinal relaxivity.
Abstract The tripodal receptors 1 and 2 based on a triethylbenzene scaffold substituted with trihydroxybenzoyl groups have been synthesised. conformational preferences carbohydrate‐binding ability of examined by NMR spectroscopy modelling procedures. results reveal that the particular structural pre‐organisation facilitates recognition, in highly competitive medium (DMSO), mannose‐based polysaccharide consisting linear saccharide chain continuously decorated α(1→2)‐linked branching mannose...
An archetypal anti-inflammatory compound against cytokine storm would inhibit it without suppressing the innate immune response. AG5, an compound, has been developed as synthetic derivative of andrographolide, which is highly absorbable and presents low toxicity. We found that mechanism action AG5 through inhibition caspase-1. Interestingly, we show with in vitro generated human monocyte derived dendritic cells preserves minimizes inflammatory response a mouse model lipopolysaccharide...
Polymeric-inorganic hybrid nanomaterials have emerged as novel multifunctional platforms because they combine the intrinsic characteristics of both materials with unexpected properties that arise from synergistic effects. In this work, nanogels based on mesoporous silica nanoparticles, oligo (ethylene glycol) methacrylates, and acidic moieties were developed employing ultrasound-assisted free radical precipitation/dispersion polymerization. Chemical structure was characterized by infrared...
To understand the factors that control formation of biomolecular corona, a systematic study adsorption several miRNAs shown to be important in prostate cancer on amine-functionalized mesoporous silica nanoparticles (MSN-NH2) has been performed. Process parameters including miRNA type, nanoparticle concentration, incubation temperature and time were investigated, as well potential competition for between different molecules. The influence proteins particle PEGylation also explored. We found...