A5037508831- Advanced MRI Techniques and Applications
- Lipid Membrane Structure and Behavior
- Medical Image Segmentation Techniques
- Advanced Neuroimaging Techniques and Applications
- Botulinum Toxin and Related Neurological Disorders
- EEG and Brain-Computer Interfaces
- Hepatitis C virus research
- Tactile and Sensory Interactions
- Brain Tumor Detection and Classification
- Liver Disease Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Stroke Rehabilitation and Recovery
- Monoclonal and Polyclonal Antibodies Research
- Magnetism in coordination complexes
- Cervical and Thoracic Myelopathy
- Cell death mechanisms and regulation
- Treatment of Major Depression
- Spinal Fractures and Fixation Techniques
- Glioma Diagnosis and Treatment
- Peripheral Nerve Disorders
- Pluripotent Stem Cells Research
- Trypanosoma species research and implications
- HIV-related health complications and treatments
- Phagocytosis and Immune Regulation
- CNS Lymphoma Diagnosis and Treatment
Instituto Bernabeu
2024
Universitat de Miguel Hernández d'Elx
2002-2022
Hospital General Universitario de Alicante Doctor Balmis
2009-2021
Insoco (Spain)
2014-2017
Hospital Vega Baja
2011
Abstract Recent research suggests that neuroplastic and neuroinflammatory changes may account for the mode of action electroconvulsive therapy (ECT), although extant data do not allow a clear disambiguation between these two hypotheses. Multimodal neuroimaging approaches (for example, combining structural metabolic information) help in clarifying this issue. Here we aimed to assess longitudinal (i) regional gray matter (GM) volumes (ii) hippocampal metabolite concentrations throughout an...
Sensory substitution devices (SSDs) are providing new ways for improving or replacing sensory abilities that have been lost due to disease injury, and at the same time offer unprecedented opportunities address how nervous system could lead an augmentation of its capacities. In this work we evaluated a color-blind subject using visual-to-auditory SSD device called "Eyeborg", allows colors be perceived as sounds. We used combination neuroimaging techniques including Functional Magnetic...
We have identified the membrane-active regions of full sequences HCV E1 and E2 envelope glycoproteins by performing an exhaustive study membrane leakage, hemifusion, fusion induced 18-mer peptide libraries on model membranes having different phospholipid compositions. The data their comparison led us to identify segments which might be implicated in viral fusion, interaction, and/or protein−protein binding. Moreover, it has permitted suggest that located glycoprotein and, more specifically,...
Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is a recently defined inflammatory central nervous system disorder characteristic magnetic resonance imaging (MRI) features. We report 69-year-old man presenting gait ataxia the MRI features of CLIPPERS and describe clinical, MRI, spectroscopy (MRS) follow-up after treatment glucocorticosteroids. Brain spine showed punctate peppering brainstem, cerebellar peduncles, upper cervical cord....
The HIV-1 gp41 envelope glycoprotein is responsible for the membrane fusion between virus and target cell. According to recent models, N-terminal coiled-coil (NHR) region of involved in forming interfaces neighboring helices six-helix bundle, as well binding perturbation. In order get new insights into viral mechanism, two peptides, pFP15 pFP23, pertaining first part NHR domain were studied regarding their structure ability induce leakage, aggregation, fusion, affinity toward specific...
We have identified the membrane-active regions of hepatitis C virus p7 protein by performing an exhaustive study membrane rupture, hemifusion, and fusion induced a p7-derived peptide library on model membranes having different phospholipid compositions. report identification in highly membranotropic region located at loop domain protein. Here, we investigated interaction patterned after (peptide p7L), studying its binding with lipid bilayer, evaluated binding-induced structural changes...
Gd and Fe centers closely packed in a Gd(H<sub>2</sub>O)<sub>4</sub>[Fe(CN)<sub>6</sub>]@SiO<sub>2</sub>network promote magnetic synergistic effect, which improves longitudinal relaxivity.
To evaluate the usefulness of diffusion tensor imaging (DTI) in clinical setting as a complementary tool to conventional MRI study and assessment sciatic nerve its pathologies.17 patients diagnosed with different types neuropathy 10 healthy controls underwent DTI 3-T MR scanner (Achieva(®) X-Series; Philips Healthcare, Netherlands).In control group, we were able track visualize common main branches from hip foot. In patient affected nerves presented statistically significant lower fractional...
We describe the synthesis, characterization and application as contrast agents in magnetic resonance imaging of a novel type nanoparticle based on Gd-Si oxide, which presents high Gd
The severe acute respiratory syndrome coronavirus (SARS-CoV) envelope spike (S) glycoprotein, a Class I viral fusion protein, is responsible for the between membranes of virus and target cell. In order to gain new insight into protein membrane alteration leading mechanism, peptide pertaining putative pre-transmembrane domain (PTM) S glycoprotein has been studied by infrared fluorescence spectroscopies regarding its structure, ability induce leakage, aggregation, fusion, as well affinity...
Objectives Vitamin D is thought to play a role in glucose homeostasis and beta cell function. Our aim was examine the impact of plasma 25‐hydroxyvitamin [25( OH ) ] upon vivo insulin sensitivity function HIV ‐infected male patients without diabetes. Methods A cross‐sectional study carried out involving cohort undergoing regular assessment tertiary hospital. Eighty‐nine [mean (± standard deviation) age 42 ± 8 years] were included study: 14 antiretroviral therapy ( ART )‐naïve, while 75 on ....
A novel approach to the synthesis of Gd-Si oxide mesoporous nanoparticles with a high Gd(3+) atom density and pre-formed morphology is presented. Prussian blue analogue Gd(H2O)4[Fe(CN)6], metal organic framework that crystallizes in orthorhombic system, used for first time as sacrificial template by reaction soluble silicate. Simultaneous stoichiometric condensation gadolinium hydroxide silica takes place, leading dense monodispersed preserve original shape size crystals. Then, porosity...
Cognitive impairment (CI) is frequently present in multiple sclerosis patients. Despite ongoing research, the neurological substrates have not been fully elucidated. In this study we investigated contribution of gray and white matter CI observed mildly disabled relapsing-remitting (RRMS) For that purpose, 30 patients with RRMS (median EDSS = 2), age- sex-matched healthy controls were studied. was assessed using symbol digit modalities test (SDMT) memory alteration test. Brain magnetic...
This paper addresses the functional localization of intra-patient images brain. Functional brain (fMRI and PET) provide information about function metabolism whereas anatomical (MRI CT) supply structures with high spatial resolution. The goal is to find geometric correspondence between in order complement fuse provided by each imaging modality. proposed approach based on a variational formulation image registration problem frequency domain. It has been implemented as C/C[Formula: see text]...